Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-27T13:47:39.606Z Has data issue: false hasContentIssue false
  • English
  • Français

Intrapair Differences of the Blood Cell Components and Lymphocyte Subsets in Monozygotic and Dizygotic Twins

Published online by Cambridge University Press:  01 August 2014

Y. Yokoyama  and
T. Akiyama
Y. Yokoyama*
Affiliation:
Department of Public Health, Kinki University School of Medicine, 377, Ohnohigashi Osakasayama city, Osaka, 589, Japan
T. Akiyama
Affiliation:
Central Clinical Laboratory, Kinki University Hospital, 377, Ohnohigashi Osakasayama city, Osaka, 589, Japan
*
Department of Public Health, Kinki University School of Medicine, 377, Ohnohigashi Osakasayama city, Osaka, 589, Japan

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We evaluated the relative influence of genetic and environmental factors on leukocytes, lymphocytes, neutrophils, monocytes, erythrocytes, reticulocytes, hemoglobin, platelets, T lymphocyte subsets, and NK marker cells in monozygotic (MZ) and dizygotic (DZ) twins. Peripheral blood components were measured in 154 healthy twin pairs (118 MZ pairs and 36 DZ pairs) and lymphocyte subsets in 48 healthy twin pairs (38 MZ pairs and 10 DZ pairs).

Platelets and erythrocytes showed higher intraclass correlations in the MZ pairs than in the DZ pairs in the males. However, in the females, the intraclass correlations for these components were similar between the MZ and DZ pairs. Neutrophils and monocytes showed low intraclass correlations in the MZ pairs. The absolute number of CD4+ cells and the CD4+/CD8+ cell ratio showed high intraclass correlations regardless of age in the MZ pairs in both males and females. The intraclass correlation for the absolute number of CD3+ cells was low in pairs aged ≥ 60 years in the MZ pairs. The absolute numbers of CD16+ cells and CD56+ cells showed high intraclass correlations regardless of age in the MZ pairs.

Keywords

TwinsPlateletErythrocyteT lymphocyte subsetNK cellAge
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 44 , Issue 3-4 , October 1995 , pp. 203 - 214
Copyright
Copyright © The International Society for Twin Studies 1995

References

REFERENCES

1. Abo, T, Cooper, MD, Balch, CM (1982): Postnatal expansion of the natural killer and killer cell population in humans identified by the monoclonal HNK-1 antibody. J Exp Immunol 155: 321–326.Google ScholarPubMed
2. Abo, T, Miller, C, Balch, C (1984): Characterization of human granular lymphocyte subpopulations expressing HNK-1 (Leu-7) and Leu-11 antigens in the blood and lymphoid tissues form fetuses, neonates and adults. Eur J Immunol 14: 616–623.CrossRefGoogle ScholarPubMed
3. Awanaka, T, Ishikawa, E (1979): Shin Tokei Gaku. Tokyo: Maki Books.Google Scholar
4. Davey, MP, Meyer, MM., Bakke A, C (1994): T cell receptor Vβ gene expression in monozygotic twins, discordance in CD8 subset and in disease states. Journal of Immunology 152: 315–321.CrossRefGoogle Scholar
5. Dunlap, NE, Ballinger, S, Reed, T, Christian, JC, Koopman, WJ, Briles, DE (1993): The use of monozygotic and dizygotic twins to estimate the effects of inheritance on the levels of immunoglobulin isotypes and antibodies to phosphocholine. Clinical Immunology and Immunopathology 66: 176–180.CrossRefGoogle ScholarPubMed
6. Ericsson, CH, Svartengren, M, Mossberg, B, Camner, P (1993): Bronchial reactivity, lung function, and serum immunoglobulin E in smokingdiscordant monozygotic twins. Am Rev Respir Dis 147: 296–300.CrossRefGoogle ScholarPubMed
7. Goto, M, Nishioka, K (1989): Age- and sex-related changes of the lymphocyte subsets in healthy individuals: an analysis by two-dimensional flow cytometry. Journal of Gerontology 44: M51–56.CrossRefGoogle ScholarPubMed
8. Hanson, B, McGue, M, Roitman-Johnson, B, Segal, NL, Bouchard, TJ, Blumental, MN (1991): Atopic disease and immunoglobulin E in twins reared apart and together. Am J Hum Genet 48: 873–879.Google ScholarPubMed
9. Hayakawa, K, Shimizu, T, Ohba, Y, Tomioka, S (1987): Lifestyle factors affecting intrapair differences of serum apoproteins and cholesterol concentrations in adult identical twins. Atherosclerosis 66: 1–9.CrossRefGoogle ScholarPubMed
10. Hayakawa, K, Shimizu, T (1987): Blood pressure discordance and lifestyle; Japanese identical twins reared apart and together. Acta Genet Med Gemellol 36: 485–491.Google ScholarPubMed
11. Japan Ministry of Health and Social Welfare (1984): Population Survey by Occupation and Industry in 1984. Tokyo: Japan Ministry of Health and Social Welfare.Google Scholar
12. Matour, D, Melnicoff, M, Kaye, D, Murasko, DM (1989): The role of T cell phenotypes in decreased lymphoproliferation of the elderly. Clinical immunology and immunopathology 50: 82–99.CrossRefGoogle ScholarPubMed
13. Paoli, PD, Battistin, S, Santini, GF (1988): Age-related changes in human lymphocyte subsets: progressive reduction of the CD4 CD45R (suppressor inducer) population. Clinical immunology and immunopathology 48: 290–296.CrossRefGoogle ScholarPubMed
14. Peakman, M, Alviggi, L, Hussain, MJ, Lo, SSS, Hawa, M, Leslie, RDG, Vergani, D (1994): Increased expression of T-cell markers of immunological memory associated with protection from type I diabetes. Diabetes 43: 712–717.CrossRefGoogle ScholarPubMed
15. Reichert, T, DeBruyere, M, Deneys, V, Totterman, T, Lydyard, P, Yuksel, F, Chapel, H, Jewell, D, Hove, LV, Linden, J, Buchner, L (1991): Lymphocyte subset reference ranges in adult caucasians. Clinical Immunology and Immunopathology 60: 190–208.CrossRefGoogle ScholarPubMed
16. Snedecor, GW, Cochran, WG (1984): Statistical Methods 6th Edn. Translated by Hatamura, Y, et al., Tokyo: Iwanamishoten.Google Scholar
17. Yokoyama, Y, Shimizu, T, Hayakawa, K (1995): Prevalence of cerebral palsy in twins, triplets, and Quadruplets. International Journal of Epidemiology 24: 943–948.CrossRefGoogle ScholarPubMed
18. Yokoyama, Y, Shimizu, T, Hayakawa, K (1995): Incidence of handicaps in multiple births and associated factors. Acta Genet Med Gemellol (in press).Google Scholar
19. Yokoyama, Y, Shimizu, T, Hayakawa, K (1995): Handicaps in twins and triplets. Jpn J Hyg 49: 1013–1018.CrossRefGoogle ScholarPubMed