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Preliminary Findings from a Study of the Effects of a Challenge Dose of Alcohol in Male Twins

Published online by Cambridge University Press:  01 August 2014

M.J. Cobb ,
R.A. Blizard ,
D.W. Fulker  and
R.M. Murray
M.J. Cobb*
Affiliation:
Institute of Psychiatry, University of London
R.A. Blizard
Affiliation:
Institute of Psychiatry, University of London
D.W. Fulker
Affiliation:
Institute of Psychiatry, University of London
R.M. Murray
Affiliation:
Institute of Psychiatry, University of London
*
Laboratoire de Biologie et Génétique Evolutives, CNRS, F-91190 GifSur-Yvette, France

Abstract

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Twelve pairs of MZ and 7 of DZ normal adult male twins were given a challenge dose of 0.8 mg ethanol per kg body weight diluted to a 30% v/v solution. Measures of blood alcohol, mood, craving for alcohol, body sway, heart rate and four psychomotor tasks were taken before, during and after intoxication. Genetic factors were found to be involved in the response of heart rate, body sway and two of the psychomotor tasks, but not in changes in blood alcohol, alertness or craving for alcohol. Drinking habits did not exert a strong influence upon acute responses to alcohol, but were significantly related to craving for alcohol whilst intoxicated.

Keywords

Alcohol intoxicationTwinsGenetic factors
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 3 , July 1984 , pp. 451 - 456
Copyright
Copyright © The International Society for Twin Studies 1984

References

REFERENCES

1.Bond, A, Lader, M (1974): The use of analogue scales in rating subjective feelings. Br J Med Psychol 47: 211–218.CrossRefGoogle Scholar
2.Clifford, CA, Fulker, DW, Curling, HMD, Murray, RM (1981): Preliminary findings from a twin study of alcohol use. In Gedda, L, Parisi, P, Nance, WE (eds): Twin Research 3: Part C, Epidemiological and Clinical Studies. New York: Alan R Liss, p 47–52.Google Scholar
3.Edwards, GJ, Hensman, C, Chandler, J, Peto, J (1972): Motivation for drinking among men: survey of a London suburb. Psychol Med 2:260–271.Google Scholar
4.Propping, P (1977): Genetic control of ethanol action on central nervous system. Hum Genet 35:309–334.CrossRefGoogle ScholarPubMed
5.Propping, P (1977): Psychophysiologic test performance in normal twins and in a pair of identical twins with essential tremor that is suppressed by alcohol. Hum Genet 36:321–325.CrossRefGoogle Scholar
6.Vandenberg, SG, Stafford, RE, Brown, AM (1968): The Louisville Twin Study. In Vandenberg, SG (ed): Progress in Human Behaviour Genetics. Baltimore, Maryland: John Hopkins.Google Scholar