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President's Address: Twinning in Families of Triplets

Published online by Cambridge University Press:  01 August 2014

A.W. Eriksson
A.W. Eriksson*
Affiliation:
Institute of Human Genetics, Free University of Amsterdam, The Netherlands, and Folkhälsan Institute of Genetics, Population Genetics Unit, Helsinki, Finland
*
Institute of Human Genetics, Medical Faculty, Free University, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands

Abstract

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A study was conducted on twinning in relatives of consecutive triplet sets in the Åland Islands in the years 1740-1939. The incidence of twinning in sibships of triplets was extremely high, 80/1000 (56/1000 before and 143/1000 after the triplet maternity). In Finland as a whole, 1905-1954, the twinning rate was among mothers of triplets 38/1000, ie, about 2.6 times the rate in general population, and was higher after (48/1000) than before the triplet maternity (34/1000). In the sibships of fathers of triplets there was a low rate of twinning (below 10/1000) both of same-sexed (SS) and of opposite-sexed (OS) triplets. Among sibships of mothers of OS triplets the twinning rate was 18/1000 and among mothers' sibships of SS triplets 26/1000. The series of triplet families from both Åland and Finland as a whole indicate a considerably higher frequency of twinning on the maternal than on the paternal side. The sibships of OS triplets in Finland have higher twinning rates than sibships of SS triplets (50/1000 vs 27/1000). In sibships of triplets, not only the DZ but also the MZ twinning rates were approximately twice as high as those in the general population. The triplet rates in Finland were increasing strongly with maternal age and were in the last century among mothers of 30-39 years of age considerably higher than among mothers from this century. This, in combination with higher mean parity, may explain the high rates of multiple maternities in sibships of triplets in the past. The rate of triplet maternities seems to be more sensitive to sociodemographic changes than the rate of twin maternities. Mothers of triplets in Finland had a high frequency (more than 40%) of prenuptially conceived firstborn children. This, and a short protogenesic interval indicate that triplet-prone mothers are more fecundable, ie, they conceive with greater ease and/or may have a better physical condition than other women for completing a gestation with multiple embryos.

Keywords

FecundityInheritance of multiple maternitiesTripletsTwinningÅland IslandsFinland
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 3 , July 1990 , pp. 279 - 293
Copyright
Copyright © The International Society for Twin Studies 1990

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