Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-28T20:39:08.740Z Has data issue: false hasContentIssue false
  • English
  • Français

Relationship Between Blood Uric Acid Level and Personality Traits

Published online by Cambridge University Press:  01 August 2014

S. Ooki ,
K. Yamada  and
A. Asaka
S. Ooki*
Affiliation:
School of Health Sciences, Faculty of Medicine, University of Tokyo, Japan
K. Yamada
Affiliation:
Department of Nursing, Sapporo Medical College, Japan
A. Asaka
Affiliation:
Department of Health Sciences, Yamanashi Medical College, Japan
*
Dept. of Mental Health, Tokyo University, 7-3-1 Hongo Bunkyoku, Tokyo 113, Japan

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The present study deals with the relationship between blood uric acid level and human behavior. Subjects were 37 MZ and 7 DZ twins aged from 18 to 45 years. In males, blood uric acid level increased with age, while it decreased with age in females. Blood uric acid level was corrected and standardized using regression lines separately for males and females. The distribution of standardized uric acid level corresponded well with the theoretical curve of normal distribution. The intraclass correlation coefficient for standardized uric acid level was r = 0.370 (P < 0.05) for the 37 MZ twins, but not significant for the 7 DZ twins. These findings suggest that blood uric acid level is genetically controlled. By the analysis of 12 personality traits in YG (Yatabe-Guilford) character test, it was revealed that “General activity” was more controlled by genetically than environmentally. In the evaluation of the correlation between standardized uric acid level and the YG 12 personality traits, significant correlation was observed in “Lack of agreeableness” and “Rhathymia”. Since these two personality traits include the factor of “activity”, it is concluded that the plasma uric acid level and activity in a broader sense are under genetic control. This conclusion is consistent with the generally accepted view that persons with high uric acid level are more active and energetic than those with low level.

Keywords

Uric acidTwinsPersonality traits
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 39 , Issue 1 , January 1990 , pp. 117 - 122
Copyright
Copyright © The International Society for Twin Studies 1990

References

REFERENCES

1.Anumonye, A, Pharm, D, Dobson, JW, Oppenhein, S, Sutherland, JS, (1969): Plasma uric acid concentrations among Edinburgh business executive. JAMA 208: 1141–1144CrossRefGoogle Scholar
2.Becker, MA, Seegmiller, JE (1974): Genetic aspects of gout. Annu Rev Med 25:15–28CrossRefGoogle ScholarPubMed
3.Brooks, GS, Mueller, E (1966): Serum urate concentrations among university professors, JAMA 195:415–418CrossRefGoogle ScholarPubMed
4.Dunn, JP, Brooks, GW, Mansner, J, Rodman, GP, Cobb, S (1963): Social class gradient of serum uric acid levels in man. JAMA 185: 431–436Google Scholar
5.Inouye, E, Park, KS, Asaka, A (1984): Blood uric acid level and IQ: A Study in twin families. Acta Genet Med Gemellol 33: 237–242Google ScholarPubMed
6.Kasl, SV, Brooks, GW, Cobb, S (1966): Serum urate concentrations in male highschool students, JAMA 198:713–716Google Scholar
7.Montoye, HJ, Faulkner, JA, Dodge, HJ, Mikkelsen, WM, Willis, WM, Block, WD (1967): Serum uric acid concentration among business executive with observation on other coronary heart disease risk factors. Ann Int Med 66: 838–850Google Scholar
8.Orowan, E (1955): Origin of man. Nature 175: 683–684CrossRefGoogle ScholarPubMed
9.Park, K, Inouye, E, Asaka, A (1980): Plasma and urine uric acid levels: Heritability estimates and correlation with IQ. Jpn J Hum Genet 25: 193–202CrossRefGoogle ScholarPubMed
10.Rich, RL, Nance, WE, Corey, LA, Boughman, JA (1978): Evidence for genetic factors influencing serum uric acid levels in man. In Nance, WE, Allen, G, Parisi, P (eds): Twin Research, Part C: Clinical Studies. New York: Alan R Liss, pp. 187–192Google Scholar
11.Stetten, D Jr, Hearon, JZ (1959): Intellectual level measured by Army Classification Battery and serum uric acid concentration. Science 129: 1737CrossRefGoogle ScholarPubMed