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Tre Coppie di Gemelle in Tre Generazioni Successive Nate da Madri Gemelle

Published online by Cambridge University Press:  01 August 2014

G. Andreano ,
M. Dobosz ,
I. Boschi ,
L. E. Ruscitti ,
A. Liberti  and
D. Casa
G. Andreano*
Affiliation:
Servizio di Genetica Medica, Università degli Studi “La Sapienza” di Roma”
M. Dobosz
Affiliation:
Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore di Roma
I. Boschi
Affiliation:
Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore di Roma
L. E. Ruscitti
Affiliation:
Servizio di Genetica Medica, Università degli Studi “La Sapienza” di Roma”
A. Liberti
Affiliation:
Servizio di Genetica Medica, Università degli Studi “La Sapienza” di Roma”
D. Casa
Affiliation:
Servizio di Genetica Medica, Università degli Studi “La Sapienza” di Roma”
*
c/o Servizio di Genetica Medica (, Primario: Prof. D. Casa), Dipartimento di Medicina Sperimentale, Policlinico Umberto I, Università degli Studi di Roma “La Sapienza”, Viale Regina Elena 324, 00161 Roma

Abstract

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It is generally held that there are genetic factors for dizygotic (DZ) twinning, but the pattern of inheritance is far from clear.

We report on a rare pedigree with three sets of spontaneous DZ female twin births in three successive generations. To our knowledge no similar pedigrees have been reported in literature.

Zygosity determination in three pairs of twins was performed with ABO, MN and Rh blood groups from erythrocytes and with STR analysys from samples of saliva.

In our pedigree, the direct trasmission of the DZ twinning through the maternal line seems show an autosomal dominant pattern of inheritance. We believe that the inheritance of DZ twinning appears to be recessive in most case and autosomal dominant only in rare instances. It is plausible with the hypothesis that the expression of the dizygotic twinning trait in a mother shows a genetic heterogeneity.

Keywords

TwinsDizygotic twinningZygosity determinationSTR analysisPedigree studyAutosomal dominant
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 47 , Issue 1 , January 1998 , pp. 43 - 49
Copyright
Copyright © The International Society for Twin Studies 1998

References

BIBLIOGRAFIA

1.Bulmer, MG (1970): The biology of twinning in man. Oxford University Press, Oxford.Google Scholar
2.Chenevix-Trench, G, Sue, Healey, Martin, NG (1993): Reproductive hormone genes in mothers of spontaneous dizygotic twins: an association study. Hum Genet 91: 118–120.Google Scholar
3.Dahlberg, G (1926): Twin births and twins from a hereditary point of view. A.B. Tdens Trycker, Stockholm.Google Scholar
4.Danforth, CH (1916): Is twinning hereditary? Journal of Heredity 7: 195–202.Google Scholar
5.Derom, C, Vlietink, R, Derom, R, Van den Berghe, H, Thiery, M (1987): Increased monozygotic twinning rate after ovulation induction. Lancet 1: 1236–1238.CrossRefGoogle ScholarPubMed
6.Gedda, L (1951): Studio dei Gemelli, Edizione Orizzonte Medico. Roma.Google Scholar
7.Gedda, L, Russo, O, Capone, M (1974): Heredity of twinning in families of MZ twins. Acta Genet Med Gemellol (special issue) 23: 18.Google Scholar
8.Greulich, WW (1934): Heredity in human twinning. Am J Physic Antropology 19: 391–431.CrossRefGoogle Scholar
9.Kallen, B, Thorbert, G (1985): Study of pregnancy outcome in a small area around a chemical factory and a chemical dump. Environmental Research 37: 313–319.Google Scholar
10.Kimpton, CP, Walton, A, Gill, P (1992): A further tetranucleotide repeat polymorphism in vWF gene. Hum Mol Genet 1: 28.Google Scholar
11.Lenz, F (1933): Zur frage der ursachen von zwillingsgeburten. Archives für Rassen und Gesselschaftsbiologie 27: 294–318.Google Scholar
12.Milham, S (1964): Pituitary gonadotrophin and dizygotic twinning. Lancet II: 566 only.Google Scholar
13.Montgomery, GW, Crawford, AM, Penty, JM, Dodds, KG, Ede, AJ, Henry, HM, Pierson, CA, Lord, EA, Galloway, SM, Schmack, AE, Sise, JA, Swarbrick, PA, Hanrahan, V, Buchanan, FC, Hill, DF (1993): The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human choromosome 4q. Nature Genet. 4: 410–414.Google Scholar
14.Nylander, PPS (1970): The inheritance of dizygotic twinning. A study of 18,737 maternities in Ibadan, Western Nigeria. Acta Genet Med Gemellol 19: 36–39.Google Scholar
15.Nylander, PPS (1979): The twinning incidence in Nigeria. Acta Genet Med Gemellol 28: 261–63.Google Scholar
16.Parisi, P, Gatti, M, Prinzi, G, Caperna, G (1983): Familial incidence of twinning. Nature 304: 626–628.CrossRefGoogle ScholarPubMed
17.Peal, WJ (1965): East African sources of steroidal components of potential value as hormone precursors. Proceedings of East African Academy, III: 9–13.Google Scholar
18.Philippe, P (1981): Twinning and the changing pattern of breast-feeding: a possible relationship in a small rural population. Soc Biol 28: 167–175.Google Scholar
19.Philippe, P (1985): Genetic epidemiology of twinning a population-based study. Am J Med Genet 20: 97–105.Google Scholar
20.Polymeropoulos, MH, Xiao, H, Merril, CR (1992): Tetranucleotide repeat polymorphism at the human myelin basic protein gene (MBP). Hum Mol Genet 1 (8): 658.CrossRefGoogle ScholarPubMed
21.Waterhouse, JAH (1950): Twinning in twin pedigrees. British Journal of Social Medicine 4: 197–216.Google Scholar
22.Weinberg, W (1909): Die Analage zur Mehrlingsgeburt beim Menschen und ihre Vererbung. Archives für Rassen und Gesselschaftsbiologie 6: 322-39, 470-82, 609–30.Google Scholar
23.White, C, Wyshak, G (1964): Inheritance in human dizygotic twinning. New Engl J Med 271: 1003–12.CrossRefGoogle ScholarPubMed
24.Wyshak, G, White, C (1965): Genealogical study of human twinning. Am J Public Health 55: 1586–93.CrossRefGoogle ScholarPubMed