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Ultrasonic Evaluation of Twin Pregnancies Associated With Raised Serum Alpha-Fetoprotein Levels

Published online by Cambridge University Press:  01 August 2014

J.P. Neilson*
Affiliation:
Queen Mother's Hospital, Glasgow, Scotland
V.D. Hood
Affiliation:
Queen Mother's Hospital, Glasgow, Scotland
W. Cupples
Affiliation:
Queen Mother's Hospital, Glasgow, Scotland
*
Department of Obstetrics and Gynecology, Harare Central Hospital, P.O. Box ST 14, Southerton, Harare, Zimbabwe

Abstract

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Five cases of twin pregnancy associated with elevated maternal serum alpha-fetoprotein levels are presented. In each instance an abnormality was detected by ultrasound examination—in four cases this represented anomalous development of one or both fetuses: discordant anencephaly; a monozygotic heterokaryotypic twin pregnancy with coexistent Turner's syndrome and intrauterine death; concordant body-stalk syndrome; and fetal exomphalos together with an acardiac monster. In the remaining case, there had been an intrauterine death of one of the twins. Ultrasound examination proved valuable in all instances; three pregnancies were terminated and single healthy infants were delivered from each of the other two pregnancies.

Type
Research Article
Copyright
Copyright © The International Society for Twin Studies 1982

References

REFERENCES

1. Aberg, A, Mitelman, F, Cantz, M, Gehler, J (1978): Cardiac puncture of fetus with Hurler's disease avoiding abortion of unaffected co-twin. Lancet 2:990991.CrossRefGoogle ScholarPubMed
2. Beck, L, Terinde, R, Rohrbom, G, Claussen, U, Gebauer, HJ, Rehder, H (1981): Twin pregnancy, abortion of one fetus with Down's syndrome by sectio parva, the other delivered mature and healthy. Eur J Obstet Gynecol Reprod Biol 12:267269.Google Scholar
3. Campbell, S (1981): Paper presented at British Medical Ultrasound Society Annual Scientific Meeting, London, 12, 14–15 1981.Google Scholar
4. Campbell, S, Grundy, M, Singer, JD (1976): Early prenatal diagnosis of spina bifida in twin fetus by ultrasonic examination and alpha-fetoprotein estimation. Br Med J 2:676.CrossRefGoogle ScholarPubMed
5. Clarke, PC, Gordon, YB, Kitau, MJ, Chard, T, McNeal, AD (1977): Alpha-fetoprotein levels in pregnancies complicated by gastrointestinal abnormalities of the fetus. Br J Obstet Gynaecol 84:285289.CrossRefGoogle ScholarPubMed
6. Ferguson-Smith, MA, May, HM, Vince, JD, Robinson, HP, Rawlinson, HA, Tait, HA, Gibson, AAM, Ratcliffe, JG (1978): Avoidance of anencephalic and spina bifida births by maternal serum alpha-fetoprotein screening. Lancet 1:13301333.CrossRefGoogle Scholar
7. Finlay, D, Dillon, A, Heslip, M (1981): Ultrasound screening in a twin pregnancy with high serum alphafetoprotein. J Clin Ultrasound 9:514515.CrossRefGoogle Scholar
8. Ghosh, A, Woo, JSK, Rawlinson, HA, Ferguson-Smith, MA (1982): The prognostic significance of raised serum alpha-fetoprotein levels in twin pregnancies. (Submitted for publication.)Google Scholar
9. Neilson, JP, Hood, VD, Cupples, W, Gibson, AAM, Ferguson-Smith, MA (1982): Ultrasonic detection of abnormality in twin pregnancies during the second trimester. Br J Obstet Gynaecol (in press).Google Scholar
10. Neilson, JP, Hood, VD (1980): Ultrasound in obstetrics and gynecology: Recent developments. Br Med Bull 36:249255.CrossRefGoogle Scholar
11. Robinson, HP, Hood, VD, Adam, AH, Gibson, AAM, Ferguson-Smith, MA (1980): Diagnostic ultrasound: Early detection of fetal neural tube defects. Obstet Gynecol 56:705710.Google Scholar
12. Schmidt, W, Heberling, D, Kubli, F (1981): Antepartum ultrasonographic diagnosis of conjoined twins in early pregnancy. Am J Obstet Gynecol 139:961963.CrossRefGoogle ScholarPubMed
13. U.K. Collaborative Study on alpha-fetoprotein in relation to neural tube defects (1977): Maternal serum alpha-fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy. Lancet 1:13231332.Google Scholar
14. Wald, N, Barker, S, Peto, R, Brock, DJH, Bonnar, J (1975): Maternal serum alpha-fetoprotein levels in multiple pregnancy. Br Med J 1:651652.Google Scholar
15. Worthen, NJ, Lawrence, D, Bustillo, N (1980): Amniotic band syndrome: Antepartum ultrasonic diagnosis of discordant anencephaly. J Clin Ultrasound 8:453455.CrossRefGoogle ScholarPubMed