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The Use of Microsatellites in Zygosity Diagnosis of Twins

Published online by Cambridge University Press:  06 September 2016

J. Erdmann ,
M.M. Nöthen ,
M. Stratmann ,
R. Fimmers ,
E. Franzek  and
P. Propping
J. Erdmann*
Affiliation:
Institutes of Human Genetics
M.M. Nöthen
Affiliation:
Institutes of Human Genetics
M. Stratmann
Affiliation:
Institutes of Human Genetics
R. Fimmers
Affiliation:
Medical Statistics, University of Bonn
E. Franzek
Affiliation:
Department of Psychiatry, University of Würzburg, Germany
P. Propping
Affiliation:
Institutes of Human Genetics
*
Institute of Human Genetics, University of Bonn, Wilhelmstr. 31, 5311 Bonn, Germany

Abstract

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Although numerous genetic and anthropological markers are available for determining zygosity of twins, there is still a need for a more practical and informative method in zygosity diagnosis. Dinucleotide repeats or other short repeats (microsatellites) are highly variable between individuals and offer a simple, fast, cheap, and exact approach for zygosity determination. The feasibility of a set of microsatellites to be used for this purpose is demonstrated.

Keywords

TwinsZygosity diagnosisPolymerase-chain-reaction (PCR)Highly polymorphic genetic markersDinucleotide repeats
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 42 , Issue 1 , 1993 , pp. 45 - 51
Copyright
Copyright © The International Society for Twin Studies 1993

References

REFERENCES

1. Akane, A, Matsubara, K, Shiono, H, Yamada, M, Nagakome, Y (1991): Diagnosis of twin zygosity by hypervariable RFLP markers. Am J Med Genet 41: 96–98.CrossRefGoogle ScholarPubMed
2. Hill, AVS, Jeffreys, AJ (1985): Use of minisatellite DNA probes for determination of twin zygosity at birth. Lancet 2: 1394–1395.CrossRefGoogle ScholarPubMed
3. Jones, L, Thein, SL, Jeffreys, AJ, Apperley, JF, Catovsky, D, Goldman, JM (1987): Identical twin marrow transplantation for 5 patients with chronic myeloid leukemia: Role of DNA fingerprinting to confirm monozygosity in 3 cases. Eur J Haematol 39: 144–147.CrossRefGoogle ScholarPubMed
4. Krüger, J, Propping, P (1976): Twinning frequencies in Baden-Wiirttemberg according to maternal age and parity from 1955 to 1972. Acta Genet Med Gemellol 25: 36–40.CrossRefGoogle Scholar
5. Motomura, K, Tateishi, H, Nishisho, I, Okazaki, M, Miki, T, Tonomura, A, Takai, S, Mori, T, Jeffreys, AJ (1987): The zygosity determination of Japanese twins using a minisatellite core probe. Jpn J Hum Genet 32: 9–14.CrossRefGoogle ScholarPubMed
6. Selvin, S (1977): Efficiency of genetic systems for diagnosis of twin zygosity. Acta Genet Med Gemellol 26: 81–82.CrossRefGoogle ScholarPubMed
7. Sharma, V, Litt, M (1991): Dinucleotide repeat polymorphism at the D1S117 locus. Nucleic Acids Research 19: 1168.CrossRefGoogle ScholarPubMed
8. Smith, SM, Penrose, LS (1955): Monozygotic and dizygotic twin diagnosis. Ann Hum Genet 19:273–289.CrossRefGoogle ScholarPubMed
9. Weber, JL, May, PE (1989): Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 44: 388–396.Google ScholarPubMed
10. Weber, JL, May, PE: (1990): Dinucleotide repeat polymorphism at the D4S171 locus. Nucleic Acids Research 18:2202.Google ScholarPubMed
11. Weber, JL, May, PE (1990): Dinucleotide repeat polymorphism at the D9S43 locus. Nucleic Acids Research 18: 2203.Google ScholarPubMed
12. Weber, JL, Kwitek, AE, May, PE (1990): Dinucleotide repeat polymorphisms at the D5S107, D5S108, D5S111, D5S117 and D5S118 loci. Nucleic Acids Research 18: 4035.CrossRefGoogle ScholarPubMed
13. Weber, JL, Kwitek, AE, May, PE, Patterson, D, Drabkin, H (1990): Dinucleotide repeat polymorphisms at the D8S85, D8S87, and D8S88 loci. Nucleic Acids Research 18: 4038.CrossRefGoogle ScholarPubMed
14. Weber, JL, May, PE (1990): Dinucleotide repeat polymorphism at the D10S89 locus. Nucleic Acids Research 18: 4637.CrossRefGoogle ScholarPubMed
15. Yuille, MAR, Hampson, RM, Harris, RM, Affara, NA, Yates, JRW, Ferguson-Smith, MA (1990): CA repeat polymorphism at the ASS locus. Nucleic Acids Research 18: 7472.CrossRefGoogle ScholarPubMed