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Vitamin C and the Common Cold: A Second MZ Cotwin Control Study

Published online by Cambridge University Press:  01 August 2014

A.B. Carr ,
R. Einstein ,
L.Y.C. Lai ,
N.G. Martin  and
G.A. Starmer
A.B. Carr
Affiliation:
Department of Pharmacology, University of Sydney, Canberra
R. Einstein
Affiliation:
Department of Pharmacology, University of Sydney, Canberra
L.Y.C. Lai
Affiliation:
School of Community Medicine, University of New South Wales
N.G. Martin*
Affiliation:
Department of Population Biology, Research School of Biological Sciences, Australian National University, Canberra
G.A. Starmer
Affiliation:
Department of Pharmacology, University of Sydney, Canberra
*
Department of Population Biology, Research School of Biological Sciences, Australian National University, PO Box 475, Canberra City, ACT, 2601, Australia

Abstract

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Self-reported cold data have been analyzed for 95 pairs of identical twins aged 14–64 who took part in a double-blind trial of vitamin C tablets. One member of each twin pair took a tablet containing 1 g vitamin C and the other took a well-matched placebo each day for 100 days. In the total sample there was no effect of vitamin C in preventing colds. However, subdivision of the data showed a significant preventive effect of the placebo in the 51 pairs living together and an equal and opposite preventive effect of the vitamin C in the 44 pairs living apart. The placebo effect in the pairs living together may be attributed to the large proportion who wrongly perceived which treatment they were taking. The reduction of colds in the vitamin C group of the pairs living apart was about 20%. There were significant correlations between cold symptoms reported and the personality trait of neuroticism. No side effects or substantive changes in serum biochemistry could be attributed to the vitamin C dose.

Keywords

Vitamin CColdsCotwin control studyTreatment perceptionNeuroticism
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 30 , Issue 4 , October 1981 , pp. 249 - 255
Copyright
Copyright © The International Society for Twin Studies 1981

References

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