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Metal acquisition and virulence in Brucella

Published online by Cambridge University Press:  28 May 2012

R. Martin Roop II
R. Martin Roop II*
Affiliation:
Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, 600 Moye Boulevard, Greenville, North Carolina 27834, USA
*
Corresponding author. E-mail: roopr@ecu.edu
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Abstract

Similar to other bacteria, Brucella strains require several biologically essential metals for their survival in vitro and in vivo. Acquiring sufficient levels of some of these metals, particularly iron, manganese and zinc, is especially challenging in the mammalian host, where sequestration of these micronutrients is a well-documented component of both the innate and acquired immune responses. This review describes the Brucella metal transporters that have been shown to play critical roles in the virulence of these bacteria in experimental and natural hosts.

Keywords

Brucellaironmanganesezincmagnesiumnickelbacterial iron acquisition
Type
Review Article
Information
Animal Health Research Reviews , Volume 13 , Issue 1 , June 2012 , pp. 10 - 20
Copyright
Copyright © Cambridge University Press 2012

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