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The biology of dendritic cells and their potential use in veterinary medicine

Published online by Cambridge University Press:  28 February 2007

Y. Vanloubbeeck ,
J. Hostetter  and
D. E. Jones
Y. Vanloubbeeck
Affiliation:
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
J. Hostetter
Affiliation:
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
D. E. Jones*
Affiliation:
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
*
*E-mail: jonesdou@iastate.edu Fax: (515)-294–5423
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Abstract

Dendritic cells have been shown to be the main antigen-presenting cells in vitro and in vivo, playing a pivotal role in the induction of both tolerance and immunity. Dendritic cells from humans and mice have been extensively studied and dendritic cell-based vaccines have been shown to be effective in the prevention and treatment of infectious, allergic and neoplastic diseases. Studies of dendritic cells of domestic animal origin are becoming available and confirm a role for these cells in the pathogenesis of a variety of animal diseases, suggesting that dendritic cells could be used as adjuvants for prophylactic and therapeutic strategies in veterinary medicine.

Keywords

dendritic cellsveterinary medicinepathogensvaccineimmunomodulation
Type
Review Article
Information
Animal Health Research Reviews , Volume 4 , Issue 2 , December 2003 , pp. 131 - 142
Copyright
Copyright © CAB International 2003

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