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Genetic variability and distribution of Classical swine fever virus

Published online by Cambridge University Press:  08 June 2015

Martin Beer ,
Katja V. Goller ,
Christoph Staubach  and
Sandra Blome
Martin Beer*
Affiliation:
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald–Insel Riems, Germany
Katja V. Goller
Affiliation:
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald–Insel Riems, Germany
Christoph Staubach
Affiliation:
Institute of Epidemiology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald–Insel Riems, Germany
Sandra Blome
Affiliation:
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald–Insel Riems, Germany
*
*Corresponding author. E-mail: martin.beer@fli.bund.de
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Abstract

Classical swine fever is a highly contagious disease that affects domestic and wild pigs worldwide. The causative agent of the disease is Classical swine fever virus (CSFV), which belongs to the genus Pestivirus within the family Flaviviridae. On the genome level, CSFV can be divided into three genotypes with three to four sub-genotypes. Those genotypes can be assigned to distinct geographical regions. Knowledge about CSFV diversity and distribution is important for the understanding of disease dynamics and evolution, and can thus help to design optimized control strategies. For this reason, the geographical pattern of CSFV diversity and distribution are outlined in the presented review. Moreover, current knowledge with regard to genetic virulence markers or determinants and the role of the quasispecies composition is discussed.

Keywords

Classical swine fever virusgenetic diversitygenotype distributionquasispeciesvirulence factors
Type
Review Article
Information
Animal Health Research Reviews , Volume 16 , Issue 1 , June 2015 , pp. 33 - 39
Copyright
Copyright © Cambridge University Press 2015 

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