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Immune response to bovine viral diarrhea virus—looking at newly defined targets

Published online by Cambridge University Press:  08 June 2015

Christopher C. L. Chase ,
Neelu Thakur ,
Mahmoud F. Darweesh ,
Susan E. Morarie-Kane  and
Mrigendra K. Rajput
Christopher C. L. Chase*
Affiliation:
Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, USA
Neelu Thakur
Affiliation:
Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, USA
Mahmoud F. Darweesh
Affiliation:
Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, USA South Valley University, Qena, Egypt
Susan E. Morarie-Kane
Affiliation:
Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, USA Wenatchee Valley College, Wenatchee, WA, USA
Mrigendra K. Rajput
Affiliation:
Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD, USA Medgene LLC, Brookings, SD, USA
*
*Corresponding author. E-mail: Christopher.Chase@sdstate.edu
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Abstract

Bovine viral diarrhea virus (BVDV) has long been associated with a wide variety of clinical syndromes and immune dysregulation, many which result in secondary bacterial infections. Current understanding of immune cell interactions that result in activation and tolerance are explored in light of BVDV infection including: depletion of lymphocytes, effects on neutrophils, natural killer cells, and the role of receptors and cytokines. In addition, we review some new information on the effect of BVDV on immune development in the fetal liver, the role of resident macrophages, and greater implications for persistent infection.

Keywords

bovine viral diarrhea virusBVDVmacrophagesdendritic cellsneutrophilsnatural killer cellsKupffer cellspersistent infectionliver tolerance
Type
Review Article
Information
Animal Health Research Reviews , Volume 16 , Issue 1 , June 2015 , pp. 4 - 14
Copyright
Copyright © Cambridge University Press 2015 

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