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Passive immunization with hyperimmune egg-yolk IgY as prophylaxis and therapy for poultry diseases – A review

Published online by Cambridge University Press:  16 November 2015

U. Gadde ,
T. Rathinam  and
Hyun S. Lillehoj
U. Gadde
Affiliation:
Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD 20705, USA Oak Ridge Institute for Science and Education (ORISE) Research Participation Program at the Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD 20705, USA
T. Rathinam
Affiliation:
Scientific Consultant, College Park, MD 20740, USA
Hyun S. Lillehoj*
Affiliation:
Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, Beltsville, MD 20705, USA
*
* Corresponding author. E-mail: hyun.lillehoj@ars.usda.gov
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Abstract

Passive immunization with pathogen-specific egg yolk antibodies (IgY) is emerging as a potential alternative to antibiotics for the treatment and prevention of various human and animal diseases. Laying hens are an excellent source of high-quality polyclonal antibodies, which can be collected noninvasively from egg yolks. The use of IgY offers several advantages in that it is environmentally friendly, nontoxic, and reduces the numbers of animals required for antibody production. This paper reviews the use of IgY antibodies in the treatment and prevention of enteric pathogen infections in poultry. Brief descriptions of the production, structure, and properties of IgY are also presented. Some limitations of the technology and future perspectives are discussed.

Keywords

hyperimmune IgYegg yolk antibodiesenteric infectionspoultry
Type
Review Article
Information
Animal Health Research Reviews , Volume 16 , Issue 2 , December 2015 , pp. 163 - 176
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Copyright
Copyright © Cambridge University Press 2015 

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