Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-28T00:58:02.517Z Has data issue: false hasContentIssue false
  • English
  • Français

Pathogen variation across time and space: sequencing to characterize Mannheimia haemolytica diversity

Published online by Cambridge University Press:  10 November 2014

Michael L. Clawson  and
Robert W. Murray
Michael L. Clawson*
Affiliation:
United States Department of Agriculture, Agricultural Research Service, U.S. Meat Animal Research Center, Clay Center, Nebraska, USA
Robert W. Murray
Affiliation:
Zoetis, Global Therapeutic Research, 333 Portage Street, Kalamazoo, Michigan, USA
*
*Corresponding author. E-mail: mike.clawson@ars.usda.gov
Get access Rights & Permissions [Opens in a new window]

Abstract

Bovine respiratory disease complex (BRDC) is a major animal health and economic issue that affects cattle industries worldwide. Within the USA, the beef cattle industry loses up to an estimated 1 billion dollars a year due to BRDC. There are many contributors to BRDC, including environmental stressors and viral and/or bacterial infections. One species of bacteria in particular, Mannheimia haemolytica, is recognized as the major cause of severe fibrinonecrotic pneumonia in cattle. M. haemolytica is an opportunistic pathogen that normally populates the upper respiratory tract of cattle, and invades the lower respiratory tract in stressed and/or virally infected cattle by mechanisms that are not completely understood. However, not all M. haemolytica appear to be equally pathogenic to cattle. Thus, a test could be developed to distinguish M. haemolytica genetic subtypes by their propensity to cause respiratory disease, allowing isolation and/or treatment of cattle harboring strains with an increased propensity to cause disease. To that end, the genomes of over 300 M. haemolytica strains are being sequenced.

Keywords

bovine respiratory diseaseMannheimia haemolyticapathogengenomic variation
Type
Review Article
Information
Animal Health Research Reviews , Volume 15 , Issue 2 , December 2014 , pp. 169 - 171
Check for updates
Creative Commons
This is a work of the U.S. Government and is not subject to copyright protection in the United States.
Copyright
Copyright © Cambridge University Press 2014

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Angen, Ø, Mutters, R, Caugant, DA, Olsen, JE and Bisgaard, M (1999a). Taxonomic relationships of the [Pasteurella] haemolytica complex as evaluated by DNA-DNA hybridizations and 16S rRNA sequencing with proposal of Mannheimia haemolytica gen. nov., comb. nov., Mannheimia granulomatis comb. nov., Mannheimia glucosida sp. nov., Mannheimia ruminalis sp. nov., and Mannheimia varigena sp. nov. International Journal of Systematic Bacteriology 49: 67–86.Google Scholar
Angen, Ø, Quirie, M, Donachie, W and Bisgaard, M (1999b). Investigations on the species specificity of Mannheimia (Pasteurella) haemolytica serotyping. Veterinary Microbiology 65: 283–290.Google Scholar
Caswell, JL (2014). Failure of respiratory defenses in the pathogenesis of bacterial pneumonia of cattle. Veterinary Pathology 51: 393–409.Google Scholar
Chae, CH, Gentry, MJ, Confer, AW and Anderson, GA (1990). Resistance to host immune defense mechanisms afforded by capsular material of Pasteurella haemolytica, serotype 1. Veterinary Microbiology 25: 241–251.CrossRefGoogle ScholarPubMed
Cusak, PMV, McMeniman, N and Lean, IJ (2003). The medicine and epidemiology of bovine respiratory disease in feedlots. Australian Veterinary Journal 81: 480–487.CrossRefGoogle Scholar
Foley, SL, Lynne, AM and Nayak, R (2009). Molecular typing methodologies for microbial source tracking and epidemiological investigations of Gram-negative bacterial foodborne pathogens. Infection, Genetics and Evolution 9: 430–440.Google Scholar
Frank, GH and Smith, PC (1983). Prevalence of Pasteurella haemolytica in transported calves. American Journal of Veterinary Research 44: 981–985.Google Scholar
Goering, RV (2010). Pulsed field gel electrophoresis: a review of application and interpretation in the molecular epidemiology of infectious disease. Infection, Genetics and Evolution 10: 866–875.Google Scholar
Klima, CI, Alexander, TW, Read, RR, Gow, SP, Booker, CW, Hannon, S, Sheedy, C, Mcallister, TA and Selinger, LB (2011). Genetic characterization and antimicrobial susceptibilty of Mannheimia haemolytica isolated from the nasopharynx of feedlot cattle. Veterinary Microbiology 149: 390–398.CrossRefGoogle Scholar
Klima, CL, Alexander, TW, Hendrick, S and Mcallister, TA (2014). Characterization of Mannheimia haemolytica isolated from feedlot cattle that were healthy or treated for bovine respiratory disease. Canadian Journal of Veterinary Research 78: 38–45.Google ScholarPubMed
Kudva, IT, Evans, PS, Perna, NT, Barrett, TJ, Ausubel, FM, Blattner, FR and Calderwood, SB (2002). Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms. Journal of Bacteriology 184: 1873–9.Google Scholar
Mutters, R, Angen, Ø and Bisgard, M (2005). Genus V. Mannheimia. In: Garrity, G. (ed) Bergey's Manual of Systematic Bacteriology. 2nd ed.New York: Springer, pp. 907–911.Google Scholar
Portis, E, Lindeman, C, Johansen, L and Stoltman, G (2012). A ten-year (2000–2009) study of antimicrobial susceptibility of bacteria that cause bovine respiratory disease complex–Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni – in the United States and Canada. Journal of Veterinary Diagnostic Investigation 24: 932–944.CrossRefGoogle ScholarPubMed
Quirie, M, Donachie, W and Gilmour, NJL (1986). Serotypes of Pasteurella haemolytica from cattle. The Veterinary Record 119: 93–94.Google Scholar
Radostits, OM, Gay, CC, Blood, DC and Hinchcliff, KW (2000). In: Saunders, W.B. (ed) Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Pigs, Goats and Horses. 9th edn.New York: Saunders, pp. 839–852.Google Scholar
Rice, JA, Carrasco-Medina, L, Hodgins, DC and Shewen, PE (2008). Mannheimia haemolytica and bovine respiratory disease. Animal Health Research Reviews 8: 117–128.Google Scholar
Sabat, S, Budimir, A, Nashev, D, Sá-Leão, R, Van Dijl, JM, Laurent, F, Grundmann, H, Friedrich, A and ESCMID Study Group of Epidemiological Markers (ESGEM) (2013). Overview of molecular typing methods for outbreak detection and epidemiological surveillance. Eurosurveillance 18: 20380.Google Scholar
Shoo, MK, Wiseman, A, Allan, EM, Dalgleish, RG, Gibbs, HA, Al-Hendi, AB and Selman, IE (1990). Distribution of Pasteurella haemolytica in the respiratory tracts of carrier calves and those subsequently infected experimentally with Dictyocaulus viviparus. Research in Veterinary Science 48: 383–385.Google Scholar
Singh, K, Ritchey, JW and Confer, AW (2011). Mannheimia haemolytica: Bacterial-Host Interactions in Bovine Pneumonia. Veterinary Pathology 48: 338–348.Google Scholar
Taylor, JD, Fulton, RW, Lehenbauer, TW, Step, DL and Confer, AW (2010). The epidemiology of bovine respiratory disease: what is the evidence for predisposing factors? The Canadian Veterinary Journal 51: 1095–1102.Google Scholar
Timsit, E, Christensen, H, Bareille, N, Seegers, H, Bisgaard, M and Assié, S (2013). Transmission dynamics of Mannheimia haemolytica in newly-received beef bulls at fattening operations. Veterinary Microbiology 161: 195–304.Google Scholar