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Protocol for diversion of confirmed positive bulk raw milk tankers to calf ranches – A review of the Pharmacokinetics of tetracyclines and sulfonamides in veal calves

Published online by Cambridge University Press:  18 August 2016

K. D. DeDonder ,
R. Gehring ,
L. A. Tell  and
J. E. Riviere
K. D. DeDonder*
Affiliation:
Food Animal Residue Avoidance and Depletion Program (FARAD) and Institution of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Kansas, USA
R. Gehring
Affiliation:
Food Animal Residue Avoidance and Depletion Program (FARAD) and Institution of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Kansas, USA
L. A. Tell
Affiliation:
Food Animal Residue Avoidance and Depletion Program (FARAD) and Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, California, USA
J. E. Riviere
Affiliation:
Food Animal Residue Avoidance and Depletion Program (FARAD) and Institution of Computational Comparative Medicine, Kansas State University College of Veterinary Medicine, Kansas, USA
*
*Corresponding author. E-mail: jriviere@vet.k-state.edu
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Abstract

The tetracyclines (TTC) and sulfonamides are among the most common residues found in bulk raw milk samples. Detection of drug residues in bulk milk (BM) tankers demonstrates that the product is not suitable for human consumption. Discarding BM with residue-contaminated milk is a waste of a valuable commodity, and a repurposing for consumption at calf ranches is a way to recapture some value. However, if calves consuming milk with drug residues are slaughtered for veal, their meat could contain drug residues. The objective of this review is to provide a residue avoidance strategy for TTC and sulfonamide residues in veal. To determine the pharmacokinetic properties of each drug a structured review of the literature was performed and the study inclusion criteria were that the publication used dairy breed calves, with body weight <330 kg or <6 months of age. The most pertinent parameters were determined to be plasma, tissue elimination half-lives, and systemic bioavailability. The results of this review were integrated with milk and tissue testing levels of quantification and tissue tolerances to formulate a recommended withdrawal interval for calves ingesting this milk. The suggested withdrawal interval of 20 days will ensure that no veal calves will test positive for residues from being fed this milk.

Keywords

tetracyclinechlortetracyclineoxytetracyclinesulfonamidevealresiduediscard milk
Type
Review Article
Information
Animal Health Research Reviews , Volume 17 , Issue 2 , December 2016 , pp. 127 - 136
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Copyright
Copyright © Cambridge University Press 2016 

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References

Barnes, CJ, Guyer, CG, Geleta, JN, Matusik, JE, Weber, JD, Frank, LR and Morris, GL (1990). Comparative depletion of sulfamethazine in bob veal, fancy veal, and replacement calves. Journal of Food Protection 53: 154–157.CrossRefGoogle ScholarPubMed
Bradley, BD, Allen, EH, Showalter, DH and Colaianne, JJ (1982). Comparative pharmacokinetics of chlortetracycline in milk-fed versus conventionally fed calves. Journal of Veterinary Pharmacology and Therapeutics 5: 267–278.CrossRefGoogle ScholarPubMed
Chiesa, OA, Li, H, Kijak, PJ, Li, JX, Lancaster, V, Smith, ML, Heller, DN, Thomas, MH and Von Bredow, J (2012). Tissue/fluid correlation study for the depletion of sulfadimethoxine in bovine kidney, liver, plasma, urine, and oral fluid. Journal of Veterinary Pharmacology and Therapeutics 35: 249–258.Google Scholar
Dumas, J, Goutalier, J, Quillon, JP, Rapin, A and Legoy, M (1986). Etude pharacocinetique d'une association chloramphenicol chlortetracycline chez le veau. Recueil de Medecine Veterinaire de l'Ecole d'Alfort 162: 27–35.Google Scholar
Francis, J (1949). Blood and milk levels produced by sulphone and various sulphonamides in domestic animals. Journal of Comparative Pathology 59: 245–264.Google Scholar
Gehring, R, Baynes, RE, Craigmill, AL and Riviere, JE (2004). Feasibility of using half-life multipliers to estimate extended withdrawal intervals following the extralabel use of drugs in food-producing animals. Journal of Food Protection 67: 555–560.Google Scholar
Gehring, R, Baynes, RE and Riviere, JE (2006). Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals. Journal of Veterinary Pharmacology and Therapeutics 29: 5–14.Google Scholar
Lapka, R (1980). Ontogenic changes of trimethoprim/sulfadizaine pharmacokinetics. Zentralblatt Pharmazie, Pharmakotherapie und Laboratoriumsdiagnostik 119: 1056–1059.Google Scholar
Lapka, R, Urbanova, Z, Kobylka, B, Raskova, H, Vanecek, J and Polak, L (1978). Pharmacokinetics of sulfadimidine in normal and diarrheic calves. Drug Metabolism and Disposition 6: 637–639.Google Scholar
Luthman, J and Jacobsson, SO (1983). The Availability of Tetracyclines in Calves. Nordisk Veterinaer Medicin 35: 292–299.Google ScholarPubMed
Luthman, J and Jacobsson, SO (1985). The effect of citric acid on the availability of tetracyclines in calves. Nordisk Veterinaer Medicin 37: 22–26.Google Scholar
Luthman, J and Jacobsson, SO (1987). The influence of feeding and oral rehydration on the bioavailability of oxytetracycline in calves. Acta Veterinaria Scandinavica 28: 343–348.Google Scholar
Murphy, J, Wong, M and Ray, WH (1986). The advantages of a timed-release sulfamethazine bolette for calves. Veterinary Medicine 81: 882–885.Google Scholar
National Milk Drug Residue Data Base (2013). Fiscal Year 2013 Annual Report. GLH, Incorporated.Google Scholar
Palmer, GH, Bywater, RJ and Stanton, A (1983). Absorption in calves of amoxicillin, ampicillin, and oxytetracycline given in milk replacer, water, or an oral rehydration formulation. American Journal of Veterinary Research 44: 68–71.Google ScholarPubMed
Riviere, J (2011). Comparative Pharmacokinetics Principles, Techniques and Applications. Oxford, UK: Wiley-Blackwell.CrossRefGoogle Scholar
Riviere, JE, Webb, AI and Craigmill, AL (1998). Primer on estimating withdrawal times after extralabel drug use. Journal of the American Veterinary Medical Association 213: 966–968.Google Scholar
Rolinski, Z and Halina, F (1964). Oznaczanie stezenia sulfadwumetoksypirymidyny we krwi cielat (The significance of the sulfadimethoxine concentration in blood of calves). Medycyna Weterynaryjna XX: 614–618.Google Scholar
Rusoff, LL, Hester, HH and Landagora, FT (1954–1955). Concentration of chlortetracycline in the body of dairy calves receiving nutritional levels of the antibiotic. Antibiotics Annual 348–352.Google Scholar
Schmidt, U, Woltersdorf, W, Linke, H and Leistner, L (1974). Detection of residues in calf carcases after feeding chlortetracycline, oxytetracycline, and zinc bacitracin. Fleischwirtsch 54: 513–520.Google Scholar
Sepp, S (1986). Untersuchungen zur Pharmakokinetik von Gentamycin, Ampicillin, Erythromycin, Chlortetracyclin und Sulfadimethoxin beim Mastkalb nach subkutaner oder oraler Verabreichun (Pharmacokinetic studies of ampicillin, erythromycin, chlortetracycline, and sulfdimethoxine of veal calves after subcutaneous and oral administration) . Ph.D. Thesis, University of Munich.Google Scholar
Shoaf, SE, Schwark, WS and Guard, CL (1987). The effect of age and diet on sulfadiazine/trimethoprim disposition following oral and subcutaneous administration to calves. Journal of Veterinary Pharmacology and Therapeutics 10: 331–345.Google Scholar
Sundlof, SF, Craigmill, AL and Riviere, JE (1991). Use of the food animal residue avoidance databank. Journal of the American Veterinary Medical Association 198: 816–819.Google Scholar
United States Department of Agriculture & Food and Drug Administration (2012). Tolerances for Residues of New Animal Drugs in Food. 21 CFR 556.Google Scholar
United States Department of Agriculture & Food Safety and Inspection Service (2012). New Analytic methods and Sampling Procedure for the United States National Residue Program for Meat, Poultry, and Egg Products.Google Scholar
United States Food and Drug Administration (2012). Beta Lactam and Other Test Methods for Use Under Appendix N and Section 6 of The Grade ‘A’ Pasteurized Milk Ordinance (PMO). M-a-85 (Revision #14) ed. College Park, MD.Google Scholar
Woolley, JL and Sigel, CW (1982). Development of pharmacokinetic models for sulfonamides in food animals: metabolic depletion profile of sulfdiazine in the calf. American Journal of Veterinary Research 43: 768–774.Google Scholar
Woolley, JL Jr, Sigel, CW and Wels, CM (1980). II. Novel deaminated sulfadiazine metabolites in neonatal calf tissue, plasma, and urine following oral treatment of 14C-sulfadiazine. Life Sciences 27: 1819–1826.Google Scholar