Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-11T07:58:13.692Z Has data issue: false hasContentIssue false

Production responses of lambs immunized against somatostatin

Published online by Cambridge University Press:  02 September 2010

A. S. Zainur
Affiliation:
M. C. Franklin Laboratory, Department of Animal Science, University of Sydney, Camden, New South Wales 2570, Australia
R. M. Hoskinson
Affiliation:
M. C. Franklin Laboratory, Department of Animal Science, University of Sydney, Camden, New South Wales 2570, Australia
R. C. Kellaway
Affiliation:
M. C. Franklin Laboratory, Department of Animal Science, University of Sydney, Camden, New South Wales 2570, Australia
Get access

Abstract

The production responses of crossbred lambs [Poll Dorset (♂ × (Border Leicester ♂ × Merino ♀)] immunized against somatostatin (sornatotropin release inhibiting factor; SRIF) and whose mothers were also given anti-somatostatin vaccination was investigated in this study. There were no significant differences between immunized and control lambs in term of live-weight gain, food intake, food conversion efficiency, digestibility, eating pattern, wool growth and carcass composition. The concentration of growth hormone in plasma of immune lambs was not significantly elevated, even though the lambs had a generally increasing anti-SRIF antibody titre during the experiment. The findings suggest that although the lambs were successfully immunized against SRIF, homeorhetic mechanisms maintained growth hormone and productivity traits within normal levels.

Type
Papers
Copyright
Copyright © British Society of Animal Science 1991

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bass, J. J., Gluckman, P. D., Fairclough, R. J., Peterson, A. J., Davis, S. R. and Carter, W. D. 1987. Effect of nutrition and immunisation against somatostatin on growth and insulin-like growth factors in sheep. Journal of Endocrinology 112:2731.CrossRefGoogle ScholarPubMed
Chaplin, R. K., Kerr, D. E. and Laarveld, B. 1984. Somatostatin immunization and growth in lambs. Canadian Journal of Animal Science 64: suppl., pp. 312313.CrossRefGoogle Scholar
Djura, P. and Hoskinson, R. M. 1986. Radioimmunoassay of somatostatin analogues employing Sep-Pak rapid sample purification and label assessment by high performance chromatography. Journal of Chromatography 363:424427.CrossRefGoogle Scholar
Deligeorgis, S. G., Rogdakis, E., Mantzios, A., Nikolaou, E., Evangelatos, G. and Sotiriadis-Vlahos, C. 1988. A note on the effect of active immunization against somatostatin on milk production and growth in sheep. Animal Production 46: 304308.Google Scholar
Fadlalla, A. M., Spencer, G. S. G. and Lister D. 1985. The effect of passive immunization against somatostatin on marker retention time in lambs. Journal of Animal Science 61: 234239.CrossRefGoogle ScholarPubMed
Fitzsimons, J. M. and Hanrahan, J. P. 1984. Effect of active immunization against somatostatin on the growth rate of lambs. An Foras Taluntais Animal Production Research Report, pp. 8081.Google Scholar
Galbraith, H., Wigzell, S., Scaife, J. R. and Henderson, G. D. 1985. Growth and metabolic responses of rapidly- growing male castrate lambs to immunization against somatostatin. Animal Production 40: 523 (abstr.).Google Scholar
Hoskinson, R. M., Djura, P., Welch, R. J., Harrison, B. E., Brown, G. H., Donnelly, J. B. and Jones, M. R. 1988. Failure of antisomatostatin antibodies to stimulate the growth of crossbred lambs. Australian Journal of Experimental Agriculture 28:161165.CrossRefGoogle Scholar
Laarveld, B., Chaplin, R. K. and Kerr, D. E. 1986. Somatostatin immunization and growth of lambs. Canadian Journal of Animal Science 66: 7783.CrossRefGoogle Scholar
Mears, G. J. 1989. Immunizing lambs against somatostatin to improve growth rate. Canadian Journal of Animal Science 69: 287 (abstr.).Google Scholar
Muir, L. A., Wien, S., Duquette, P. F., Rickes, E. L. and Cordes, E. H. 1983. Effects of exogenous growth hormone and diethylstilbestrol on growth and carcass composition of growing lambs. Journal of Animal Science 56:13151323.CrossRefGoogle ScholarPubMed
Plotsky, P. M. and Vale, W. 1985. Patterns of growth hormone releasing factor and somatostatin secretion into the hypothysial-portal circulation of the rat. Science, Washington 230: 461463.CrossRefGoogle ScholarPubMed
Schanbacher, B. D. 1984. Manipulation of endogenous and exogenous hormones for red meat production. Journal of Animal Science 59:16211630.CrossRefGoogle Scholar
Schally, A. V., Coy, D. H. and Meyers, C. H. 1978. Hypothalamic regulatory hormones. Annual Reviews of Biochemistry 47: 89128.CrossRefGoogle ScholarPubMed
Schuidziarra, V. 1980. Somatostatin. A regulatory modulator connecting nutrient entry and metabolism. A review. Hormone Metabolism Research 12: 563577.CrossRefGoogle Scholar
Spencer, G. S. G. 1986. Immuno-neutralisation of somatostatin and its effect on animal production. Domestic Animal Endocrinology 3: (2), 5568.CrossRefGoogle Scholar
Spencer, G. S. G., Garssen, G. J. and Bergstrom, P. L. 1983a. A novel approach to growth promotion using auto- immunization against somatostatin. II. Effects on appetite, carcass composition and food utilisation in lambs. Livestock Production Science 10: 469477.CrossRefGoogle Scholar
Spencer, G. S. G., Garssen, G. J. and Hart, I. G. 1983b. A novel approach to growth promotion using autoimmunization against somatostatin. I. Effects on growth and hormone levels in lambs. Livestock Production Science 10: 2537.CrossRefGoogle Scholar
Spencer, G. S. G., Hallett, K. G. and Fadlalla, A. M. 1985. A novel approach to growth promotion using autoimmunisation against somatostatin. III. Effects in a commercial breed of sheep. Livestock Production Science 13: 4352.CrossRefGoogle Scholar
Spencer, G. S. G. and Williamson, E. D. 1981. Increased growth in lambs following immunization against somatostatin; preliminary observations. Animal Production 32: 376 (abstr.).Google Scholar
Sun, Y. X., Drane, G. L., Currey, S. D., Lehner, N. D., Gooden, J. M., Hoskinson, R. M., Wynn, P. C. and McDowell, G. H. 1990. Immunisation against somatostatin release inhibiting factor improves digestibility of food, growth and wool production of crossbred lambs. Australian Journal of Agricultural Research 41:401411.CrossRefGoogle Scholar
Usher, C. D., Green, C. J. and Smith, C. A. 1973. The rapid estimation of fat in various food using the Fosslet density apparatus. Journal of Food Technology 8:429437.CrossRefGoogle Scholar
Varner, M. A., Davis, S. L. and Reeves, J. L. 1980. Temporal serum concentrations of growth hormone, thyrotropin, insulin and glucagon in sheep immunized against somatostatin. Endocrinology 106:10271032.CrossRefGoogle ScholarPubMed
Wagner, J. F. and Veenhuizen, E. L. 1978. Growth performance, carcass deposition and plasma hormone levels in wether lambs when treated with growth hormone and thyroprotein. Journal of Animal Science 45: suppl. 7, p. 397 (abstr.).Google Scholar
Wallace, A. L. C. and Bassett, J. M. 1970. Plasma growth hormone concentrations in sheep measured by radioimmunoassay. Journal of Endocrinology 47: 2136.CrossRefGoogle ScholarPubMed
Zainur, A. S., Hoskinson, R. M. and Kellaway, R. C. 1986. Production responses in somatostatin-immune crossbred lambs. Proceedings of the Nutrition Society of Australia 11:141.Google Scholar