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Toxicity induced by poultry litter consumption: effect on measurements reflecting liver function in beef cows

Published online by Cambridge University Press:  02 September 2010

N. Silanikove  and
D. Tiomkin
N. Silanikove
Affiliation:
Institute of Animal Science, Agricultural Research Organization, PO Box 6, Bet Dagan 50·250, Israel
D. Tiomkin
Affiliation:
‘Hachaklait’, Haifa, Israel
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Abstract

During clinical investigation of a commercial herd it was found that intake of supplemented poultry litter (PL) by beef cows at >10 kg/day, was associated with severe cachexia and a mortality rate of between 10 and 20% of cows. Postmortem analysis of 40 fresh carcasses and elevated serum levels of cholesterol, bilirubin, alkaline phosphatase, glutamic oxaloacetic transaminase and sorbitol dehydrogenase in cachetic cows indicated that the cows suffered severe liver damage. The interrelationship between liver damage and PL intake was subsequently investigated in three groups of 20 beef cows each, consuming 0, 3 and 10 kg PL respectively. As determined by the serum indices, intake of 3 kg PL seemed to be sufficient to cause liver damage, although these cows appeared healthy.

In another experiment, six beef cows were stall-fed a diet giving separate access to PL and wheat straw. PL intakes were 3·1,4·7 and 6·0 kg/day. Ruminal ammonia concentration was three to five times higher than the estimate of that required for maximal fermentation in the rumen. The high pH values (6·81 to 6·97) found are optimal for absorption of ammonia from the rumen. The combination of excess absorption of ammonia from the gut and low metabolizable energy intake might have been the cause of liver damage.

Keywords

beef cowsblood chemistryliver damagepoultry manuretoxicity
Type
Research Article
Information
Animal Production , Volume 54 , Issue 2 , April 1992 , pp. 203 - 209
Copyright
Copyright © British Society of Animal Science 1992

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References

Anderson, P. H., Matthews, J. G., Berrett, S., Brush, P. J. and Patterson, D. S. P. 1981. Changes in plasma enzyme activities and other components in response to acute and chronic liver damage in cattle. Research in Veterinary Science 31: 1–11.Google Scholar
Asada, M. and Galambos, J. T. 1968. Sorbitol dehydrogenase and hepatocellular injury: an experimental and clinical study. Gastroenterology 44: 578–580.Google Scholar
Bartholomew, M. L., Willet, L. B., Liu, T.-T. Y. and Moorhead, P. D. 1987. Changes in hepatic function tests to induced toxicity in the bovine liver. Journal of Animal Science 64: 201–209.CrossRefGoogle ScholarPubMed
Bartley, E. E., Davidovich, A. D., Barr, G. W., Griffel, G. W., Dayton, A. D., Deyoe, C. W. and Bechtle, R. M. 1976. Ammonia toxicity in cattle. 1. Rumen and blood changes associated with toxicity and treatment methods. Journal of Animal Science 43: 835–841.CrossRefGoogle Scholar
Blaker, W. D. 1987. Computer program from the parametric and nonparametric comparison of several groups to control. Computers in Biology and Medicine 17: 37–44.Google Scholar
Boyd, J. W. 1962. The comparative activity of some enzymes n i sheep, cattle and rats — normal serum and tissue levels and changes during experimental liver necrosis. Research in Veterinary Science 3: 256–268.CrossRefGoogle Scholar
Boyd, R. W. 1984. A review: the interpretation of serum biochemistry test results in domestic animals. Veterinary Clinic and Pathology 13: 12–22.Google Scholar
Clare, N. T. and Stevenson, A. E. 1964. Measurement of feed intake by grazing cattle and sheep. X. Determination of nitrogen in faeces and feeds using an autoanalyzer. New Zealand Journal ofAgricultural Research 7: 198–204.CrossRefGoogle Scholar
Deluca, H. F. 1981. Recent advances in the metabolism of vitamin D. Annual Review of Physiology 43: 199–209.Google Scholar
Ford, E. J. H. 1967. Activity of sorbitol dehydrogenase (SD) i n the serum of sheep and cattle with liver damage. Journal of Comparative Pathology 77: 405–411.Google Scholar
Ford, E. J. H. and Boyd, J. W. 1962. Cellular damage and changes in biliary excretion in a liver lesion of cattle. Journal of Pathology and Bacteriology 83: 39–44.CrossRefGoogle Scholar
Harmeyer, J. and Martens, H. 1980. Aspects of urea metabolism in ruminants with reference to the goat. Journal of Dairy Science 63: 1707–1728.CrossRefGoogle Scholar
Holzer, Z. and Levy, D. 1976. Poultry litter as a protein supplement for beef cattle fed fibrous diets. World Review of Animal Production 12: (1), 91–95.Google Scholar
Holzer, Z., Levy, D., Silanikove, N., Gutman, M. and Seligman, N. G. 1989. Effect of supplementation based mainly on poultry litter, on ruminal volatile fatty acids and ammonia in beef cows grazing Mediterranean range. Final BARD (US-Israel Binational Agricultural Research and Development Fund) Report.Google Scholar
Horst, R. L. 1986. Regulation of calcium and phosphorus homeostasis in the dairy cow. Journal of Dairy Science 69: 604–616.CrossRefGoogle ScholarPubMed
Jenkins, S. J., Green, S. A. and Clark, P. A. 1982. Clinical chemistry reference values of normal domestic animals in various age groups as determined on the ABA-100. Cornell Veterinarian 72: 403–415.Google ScholarPubMed
Katunuma, N., Okada, M. and Nishi, Y. 1966. Regulation of the urea cycle and TCA cycle by ammonia. In Advances in enzyme regulation. Vol. 4 (ed. Weber, G.), pp. 317–335. Pergamon Press, New York.Google Scholar
Masudu, S., Ukano, T., Osawa, K., Shinjo, M., Suematsu, T. and Kobayashi, T. 1989. Concentration of vitamin D-binding protein and vitamin D metabolites in plasma of patients with liver cirrhosis. Journal of Nutritional Science and Vitaminology 35: 225–234.CrossRefGoogle Scholar
Mehrez, A. Z., Ørskov, E. R. and McDonald, I. 1977. Rates of rumen fermentation in relation to ammonia concentration. British Journal of Nutrition 38: 437–443.Google Scholar
National Research Council. 1984. Nutrient requirements of beef cows. National Academic Press, Washington, DC.Google Scholar
Sawchenko, P. E. and Fridman, M. I. 1979. Sensory functions of the liver — a review. American Journal of Physiology 236: R5–R20.Google Scholar
Silanikove, N., Holzer, Z., Cohen, D., Benjamin, R., Gutman, M. and Meltzer, A. 1987. Interrelationship between metabolism of tritiated water, 22sodium and dry matter intake in beef cows fed poultry and wheat straw in free choice. Comparative Biochemistry and Physiology 88A: 113–118.Google Scholar
Tagari, H., Levy, D., Holzer, Z. and Han, D. 1976. Poultry litter for intensive beef production. Animal Production 23: 317–327.Google Scholar
Tagari, H., Silanikove, N. and Hurwitz, S. 1981. Availability of phosphorus contained in poultry litter for lambs. Journal of Nutrition 111: 405–411.CrossRefGoogle ScholarPubMed
Tiomkin, D. and Silanikove, N. 1986. [The weight loss syndrome in beef cows.] Hassadeh 66: 2336–2337.Google Scholar
Visek, W. J. 1984. Ammonia: its effects on biological systems, metabolic hormones and reproduction. Journal of Dairy Science 67: 481–498.Google Scholar
Zimmerman, H. J. 1976. Various forms of chemically induced liver injury and their detection by diagnostic. Environmental Health and Perspective 15: 3–6.Google Scholar