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Insulin-like growth factors and their binding proteins in domestic animals

Published online by Cambridge University Press:  02 September 2010

K. L. Hossner ,
R. H. McCusker  and
M. V. Dodson
K. L. Hossner
Affiliation:
Department of Animal Sciences, Colorado State University, Fort Collins, CO 80523, USA
R. H. McCusker
Affiliation:
Department of Animal Sciences, University of Illinois, Urbana, IL 61801-4737, USA
M. V. Dodson
Affiliation:
Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA
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Abstract

Insulin-like growth factors (IGFs) and their binding proteins play an essential role in regulating animal growth and metabolism. The initial portion of the current review focuses on the physiological effects of the IGFs and delineates their role as regulators of animal growth and metabolism. The role of IGFs as mediators of growth hormone effects, as insulin-like metabolic regulators and as foetal growth regulators is discussed. The remainder of the review is devoted to the IGF binding proteins, their modulation of IGF action and their role in foetal and postnatal regulation of growth.

Keywords

binding proteinsinsulin-like growth factor
Type
Research Article
Information
Animal Science , Volume 64 , Issue 1 , February 1997 , pp. 1 - 15
Copyright
Copyright © British Society of Animal Science 1997

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