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The relationships between leptin and vitamin A levels in plasma of fattening cattle supplemented with vitamin A

Published online by Cambridge University Press:  18 August 2016

T. Tokuda ,
S. Kono  and
T. Fujihara
T. Tokuda
Affiliation:
United Graduate School of Agricultural Science, Tottori University, Tottori-shi 680-8553, Japan
S. Kono
Affiliation:
Hiroshima Prefectural Livestock Technology Research Center, Shobara-shi 727-0023, Japan
T. Fujihara*
Affiliation:
Laboratory of Animal Science, Faculty of Life and Environmental Science, Shimane University, Matsue-shi, 690-8504, Japan
*
†Corresponding author. E-mail address:fujihara@life.shimane-u.ac.jp
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Abstract

The objective of this study was to examine the effect of dietary vitamin A (retinol) on leptin in cattle. The relationship between plasma leptin and insulin was also examined. The experiment studies 16 9-month-old steers over the following 20-month fattening period. Four treatment diets were given to four steers in each of four groups. Cattle in treatment A were given a diet high in vitamin A (9000 to 10500 µg/day) throughout the experiment. Cattle in treatment B were given a diet low in vitamin A (300 to 4500 µg/day) for 0 to 10 months, after that they were given the high vitamin A diet during the period 10 to 20 months. Cattle in treatment C were given the low vitamin A diet for 0 to 14 months, after that they were given the high vitamin A diet for the period 14 to 20 months. Cattle in treatment D were given the low vitamin A diet throughout the experiment. Plasma samples were collected at 2-month intervals during the experiment to determine the plasma leptin, insulin and vitamin A concentrations. Plasma leptin concentration significantly increased over the fattening period (P < 0·001) but did not differ between the treatments (P > 0·05). Plasma leptin concentration was positively correlated with insulin concentration (r = 0·44, P < 0·001), although it was not correlated with plasma vitamin A concentration (r = –0·01, P > 0·05). It was concluded that dietary vitamin A in cattle does not affect plasma leptin concentration.

Keywords

cattleinsulinleptinretinol.
Type
Growth, development and meat science
Information
Animal Science , Volume 73 , Issue 3 , December 2001 , pp. 433 - 441
Copyright
Copyright © British Society of Animal Science 2001

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References

Adachi, K., Kawano, H., Tsuno, K., Nomura, Y., Yamamoto, N., Arikawa, A., Tsuji, A., Adachi, M., Onimaru, T. and Ohwada, K. 1999. Relationship between serum biochemical values and marbling score in Japanese Black steers. Journal of Veterinary Medical Science 61: 961–964.Google Scholar
Agriculture, Forestry and Fisheries Research Council Secretariat. 1995. Japanese feeding standard for beef cattle. Central Association of Livestock Industry, Tokyo.Google Scholar
Ahima, R. S., Dushay, J., Flier, S. N., Prabakaran, D. and Flier, J. S. 1997. Leptin accelerates the onset of puberty in normal female mice. Journal of Clinical Investigation 99: 391–395.CrossRefGoogle ScholarPubMed
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R. and Burn, P. 1995. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546–549.CrossRefGoogle ScholarPubMed
Caro, J. F., Sinha, M. K., Kolaczynski, J. W., Zhang, P. L. and Considine, R. V. 1996. Leptin: the tale of an obesity gene. Diabetes 45: 1455–1462.Google Scholar
Chertow, B. S., Blaner, W. S., Baranetsky, N. G., Sivitz, W. I., Cordle, M. B., Thompson, D. and Meda, P. 1987. Effect of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets. Journal of Clinical Investigation 79: 163–169.Google Scholar
Chilliard, Y., Bocquier, F., Delavaud, C., Guerre-Millo, M., Bonnet, M., Martin, P., Faulconnier, Y. and Ferlay, A. 1998. Leptin in ruminants: effects of species, breed, adiposity, photoperiod, beta-agonists and nutritional status. Proceedings of the Cornell nutrition conference for feed manufactures, pp. 65–74.Google Scholar
Cusin, I., Sainsbury, A., Doyle, P., Rohner-Jeanrenaud, F. and Jeanrenaud, B. 1995. The ob gene and insulin: a relationship leading to clues to the understanding of obesity. Diabetes 44: 1467–1470.Google Scholar
Delavaud, C., Bocquier, F., Chilliard, Y., Keisler, D. H., Gertler, A. and Kann, G. 2000. Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep. Journal of Endocrinology 165: 519–526.Google Scholar
Ehrhardt, R. A., Slepetis, R. M., Siegal-Willott, J., Amburh, M. E. van, Bell, A. W. and Boisclair, Y. R. 2000. Development of a specific radioimmunoassay to measure physiological changes of circulating leptin in cattle and sheep. Journal of Endocrinology 166: 519–528.Google Scholar
Gregory, N. G., Truscott, T. G. and Wood, J. D. 1982. Insulin secretion in relation to fatness in cattle. Journal of the Science of Food and Agriculture 33: 276–282.Google Scholar
Hardie, L. J., Rayner, D. V., Holmes, S. and Trayhurn, P. 1996. Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochemical and Biophysical Research Communications 223: 660–665.Google Scholar
Hosoda, K., Masuzaki, H., Ogawa, Y., Miyawaki, T., Hiraoka, J., Hanaoka, I., Yasuno, A., Nomura, T., Fujisawa, Y., Yoshimasa, Y., Nishi, S., Yamori, Y. and Nakao, K. 1996. Development of radioimmunoassay for human leptin. Biochemical and Biophysical Research Communications 221: 234–239.Google Scholar
Houseknecht, K. L., Portocarrero, C. P., Ji, S., Lemenager, R. and Spurlock, M. E. 2000. Growth hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose TGF-1 expression. Journal of Endocrinology 164: 51–57.Google Scholar
Japan Meat Grading Association. 1988. New beef carcass grading standards. Japan Meat Grading Association, Tokyo, Japan.Google Scholar
Jenkins, A. B., Markovic, T. P., Fleury, A. and Campbell, L. V. 1997. Carbohydrate intake and short-term regulation of leptin in humans. Diabetologia 40: 348–351.Google Scholar
Kumar, M. V., Sunvold, G. D. and Scarpace, P. J. 1999. Dietary vitamin A supplementation in rats: suppression of leptin and induction of UCP1 mRNA. Journal of Lipid Research 40: 824–829.Google Scholar
Kuri-Harcuch, W. 1982. Differentiation of 3T3-F442A cells into adipocytes is inhibited by retinoic acid. Differentiation 23: 164–169.Google Scholar
Landt, M., Gingerich, R. L., Havel, P. J., Mueller, W. M., Schoner, B. J., Hale, E. and Heiman, M. L. 1998. Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans. Clinical Chemistry 44: 565–570.Google Scholar
Makimura, S., Matsuo, S., Usui, M. and Katayama, H. 1991. Simultaneous determination of retinol, ß-carotene and a -tocopherol in serum and liver of Japanese Black beef cattle by high performance liquid chromatography. Journal of the Japanese Veterinary Medicine Association 44: 328–332.Google Scholar
Minton, J. E., Bindel, D. J., Drouillard, J. S., Titgemeyer, E. C., Grieger, D. M. and Hill, C. M. 1998. Serum leptin is associated with carcass traits in finishing cattle. Journal of Animal Science 76:/Journal of Dairy Science 81: (joint suppl.) 231.Google Scholar
Oka, A., Maruo, Y., Miki, T., Yamasaki, T. and Saito, T. 1997. Influence of vitamin A on the quality of beef from the Tajima strain of Japanese Black cattle. Meat Science 48: 159–167.Google Scholar
Oka, A., Miki, T., Maruo, Y., Yamazaki, M., Ariyoshi, T. and Fujii, H. 1992. [Effects of vitamin A administration on meat quality of Japanese Black steers.] Journal of Clinical and Veterinary Medicine 10: 2152–2158.Google Scholar
Pairault, J., Boulange, A. Q., Dugail, I. and Lasnier, F. 1988. Differential effects of retinoic acid upon early and late events in adipose convertion of 3T3-L1 preadipocyte. Experimental Cell Research 177: 27–36.Google Scholar
Rosenbaum, M., Nicolson, M., Hirsch, J., Heymsfield, S. B., Gallagher, D., Chu, F. and Leibel, R. L. 1996. Effects of gender, body composition, and menopause on plasma concentrations of leptin. Journal of Clinical Endocrinology and Metabolism 81: 3424–3427.Google Scholar
Saladin, R., Vos, P. de, Guerre-Millo, M., Leturque, A., Girard, J., Staels, B. and Auwerx, J. 1995. Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527–529.CrossRefGoogle ScholarPubMed
Statistical Analysis Systems Institute. 1999. Stat View. SAS Institute Inc., Cary, NC.Google Scholar
Tokuda, T., Kimura, D. and Fujihara, T. 2001. The relationships between leptin and insulin in blood plasma of growing lambs. Animal Science 73: 71–76.Google Scholar
Tokuda, T., Matsui, T. and Yano, H. 2000. Effects of light and food on leptin plasma concentrations in ewes. Animal Science 71: 235–242.Google Scholar
Tokuda, T. and Yano, H. 2001. Blood leptin concentrations in Japanese Black cattle. Animal Science 72: 309–313.Google Scholar
Torii, S., Matsui, T. and Yano, H. 1996. Development of intramuscular fat in Wagyu beef cattle depends on adipogenic or antiadipogenic substances present in serum. Animal Science 63: 73–78.Google Scholar
Torii, S., Matsumoto, K., Matsui, T. and Yano, H. 1995. [Effects of vitamin A, C and D on glycerol-3-phosphate dehydrogenase activity of sheep preadipocytes in primary culture.] Animal Science and Technology 66: 1039–1042.Google Scholar
Uradate, K. 1995. [Relationship between vitamin A and meat quality in fattening cattle.] Proceedings of the Japanese Society of Animal Nutrition and Metabolism 39: 157–171.Google Scholar