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Removal of both zinc oxide and avilamycin from the post-weaning piglet diet: consequences for performance through to slaughter

Published online by Cambridge University Press:  18 August 2016

L. J. Broom ,
H. M. Miller ,
K. G. Kerr  and
P. Toplis
L. J. Broom
Affiliation:
University of Leeds, School of Biology, Leeds LS2 9JT, UK
H. M. Miller*
Affiliation:
University of Leeds, School of Biology, Leeds LS2 9JT, UK
K. G. Kerr*
Affiliation:
University of Leeds, Department of Microbiology, Leeds LS2 9JT, UK
P. Toplis
Affiliation:
Primary Diets Ltd, Melmerby Industrial Estate, Melmerby, North Yorkshire HG4 5HP, UK
*
†Corresponding author. E-mail:h.m.miller@leeds.ac.uk
‡Present address: Department of Microbiology, Harrogate Health Care Trust, Harrogate HG2 7SX, UK.
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Abstract

Avilamycin (AGP) and zinc oxide (ZnO) are both frequently included in the post-weaning piglet diet to enhance growth performance and prevent diarrhoea. This study investigated what effect removing these compounds from the post-weaning diet would have on the growth performance and faecal microbiota of weaned piglets. Fifty-two crossbred piglets (JSR Healthbred) were allocated, at weaning, to one of two dietary treatments on the basis of weight, litter origin and gender. The diets were (i) control (no supplemented ZnO or AGP); (ii) ZnO + AGP (supplemented with 3100 mg ZnO per kg food and 40 mg avilamycin per kg food). These diets were offered ad libitum for 20 days post weaning. Thereafter, the pigs received the same non-supplemented grower and finisher diets ad libitum. All piglets were individually weighed, and faecal samples were obtained from pre-selected piglets, at various time points throughout the trial period. Ten-fold serial dilutions of faecal material were cultured on specific media to enumerate aerobes, anaerobes, Lactobacillus spp. and Escherichia coli. ZnO + AGP supplementation enhanced weaned piglet average daily food intake (ADFI) (P < 0·001), average daily live-weight gain (ADG) (P < 0·001) and food conversion ratio (FCR) (P < 0·01) during the initial 20 days post weaning. Piglets previously supplemented with ZnO + AGP gained more weight per day during the non-supplemented grower phase (days 21 to 60) than their control counterparts (741·5 v. 672·5 g per pig per day) (P < 0·01). The bacteriological data showed that ZnO + AGP piglets had lower counts of anaerobic bacteria in their faeces than control piglets (P < 0·01). These findings indicate that dietary AGP + ZnO may enhance growth by reducing gastro-intestinal bacterial populations, and that their removal from the post-weaning diet will increase days to slaughter.

Keywords

avilamycingram positive bacteriagrowth promoterszinc oxide
Type
Non-ruminant nutrition, behaviour and production
Information
Animal Science , Volume 77 , Issue 1 , August 2003 , pp. 79 - 84
Copyright
Copyright © British Society of Animal Science 2003

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References

Bedford, M. 2000. Removal of antibiotic growth promoters from poultry diets: implications and strategies to minimise subsequent problems. World’s Poultry Science Journal 56: 347–365.Google Scholar
Carlson, M. S., Hill, G. M. and Link, J. E. 1999. Early- and traditionally weaned nursery pigs benefit from phasefeeding pharmacological concentrations of zinc oxide: effect on metallothionein and mineral concentrations. Journal of Animal Science 77: 1199–1207.Google Scholar
Carlson, M. S., Hill, G. M., Link, J. E., McCully, G. A., Rozeboom, D. W. and Weavers, R. L. 1995. Impact of zinc oxide and copper sulfate supplementation on the newly weaned pig. Journal of Animal Science 73: (suppl. 1) 72 (abstr.).Google Scholar
Hahn, J. D. and Baker, D. H. 1993. Growth and plasma zinc responses of young pigs fed pharmacologic levels of zinc. Journal of Animal Science 71: 3020–3024.Google Scholar
Hill, G. M., Mahan, D. C., Carter, S.D., Cromwell, G. L., Ewan, R. C., Harrold, R. L., Lewis, A. J., Miller, P. S., Shurson, G. C. and Veum, T. L. 2001. Effect of pharmacological concentrations of zinc oxide with or without the inclusion of an antibacterial agent on nursery pig performance. Journal of Animal Science 79: 934–941.CrossRefGoogle ScholarPubMed
Huang, S. X., McFall, M., Cegielski, A. C. and Kirkwood, R. N. 1999. Effect of dietary zinc supplementation on Escherichia coli septicemia in weaned pigs. Swine Health Production 7: 109–111.Google Scholar
Jensen-Waern, M., Melin, L., Lindberg, R., Johannisson, A. and Wallgren, P. P. 1998. Dietary zinc oxide in weaned pigs – effects on performance, tissue concentrations, morphology, neutrophil functions and faecal microflora. Research in Veterinary Science 64: 225–231.CrossRefGoogle ScholarPubMed
Katouli, M., Melin, L., Jensen-Waern, M., Wallgren, P. and Mollby, R. 1999. The effect of zinc oxide on the stability of the intestinal flora with special reference to composition of coliforms in weaned pigs. Journal of Applied Bacteriology 87: 564–573.Google Scholar
LeMieux, F. M., Ellison, L. V., Ward, T. L., Southern, L. L. and Bidner, T. D. 1995. Excess dietary zinc for pigs weaned at 28 days. Journal of Animal Science 73: (suppl. 1) 72 (abstr.).Google Scholar
Li, B. T., Van Kessel, A. G., Caine, W. R., Huang, S. X. and Kirkwood, R. N. 2001. Small intestinal morphology and bacterial populations in ileal digesta and feces of newly weaned pigs receiving a high dietary level of zinc oxide. Canadian Journal of Animal Science 81: 511–516.Google Scholar
McNicholas, P. M., Najarian, D. J., Mann, P. A., Hesk, D., Hare, R. S. and Shaw, K. J. 2000. Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell free systems derived from both grampositive and gram-negative bacteria. Antimicrobial Agents and Chemotherapy 44: 1121–1126.Google Scholar
Mavromichalis, I., Peter, C. M., Parr, T. M., Ganessunker, D. and Baker, D. H. 2000. Growth-promoting efficacy in young pigs of two sources of zinc oxide having either a high or a low bioavailability of zinc. Journal of Animal Science 78: 2896–2902.Google Scholar
Minitab, . 1998. Minitab for Windows, version 12·2. Minitab Inc., Pennsylvania, USA.Google Scholar
National Research Council. 1998. Nutrient requirements of swine, 10th edition. National Academic Press, Washington, DC.Google Scholar
Soderberg, T. A., Sunzel, B., Holm, S., Elmros, T., Hallmans, G. and Sjoberg, S. 1990. Antibacterial effect of zinc oxide in-vitro . Scandinavian Journal of Plastic Reconstructive Surgery and Hand Surgery 24: 193–197.Google Scholar
Smith II, J. W., Tokach, M. D., Goodband, R. D., Nelssen, J. L. and Richert, B. T. 1997. Effects of the interrelationship between zinc oxide and copper sulfate on growth performance of early-weaned pigs. Journal of Animal Science 75: 1861–1866.CrossRefGoogle Scholar
Tarnow, P., Agren, M., Steenfos, H. and Jansson, J. O. 1994. Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor-1 in granulation tissue from porcine wounds. Scandinavian Journal of Plastic Reconstructive Surgery and Hand Surgery 28: 255–259.Google Scholar
Yamamoto, O., Nakakoshi, K., Sasamoto, T., Nakagawa, H. and Miura, K. 2001. Adsorption and growth inhibition of bacteria on carbon materials containing zinc oxide. Carbon 39: 1643–1651.Google Scholar