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Bioavailability of zinc sources and their interaction with phytates in broilers and piglets

Published online by Cambridge University Press:  18 May 2012

P. Schlegel ,
D. Sauvant  and
C. Jondreville
P. Schlegel*
Affiliation:
Agroscope Liebefeld-Posieux, Research Station ALP, 1725 Posieux, Switzerland
D. Sauvant
Affiliation:
INRA, AgroParisTech, UMR791 Modélisation Systémique Appliquée aux Ruminants, F-75231 Paris, France
C. Jondreville
Affiliation:
INRA, Nancy Université, USC340 Animal et Fonctionnalités des Produits Animaux, F-54505 Vandoeuvre-les-Nancy, France
*
†E-mail: patrick.schlegel@alp.admin.ch
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Abstract

Zinc (Zn) is essential for swine and poultry and native Zn concentrations in feedstuffs are too low to meet their Zn requirement. Dietary Zn bioavailability is affected by phytate, phytase and Zn supplemented in organic form is considered as more bioavailable than inorganic sources. A meta-analysis using GLM procedures was processed using broiler and piglet databases to investigate, within the physiological response of Zn, (1) the bioavailability of inorganic and organic Zn sources (Analysis I); (2) the bioavailability of native and inorganic Zn dependent from dietary phytates, vegetal and supplemental phytase activity (Analysis II). Analysis I: the bioavailability of organic Zn relative to inorganic Zn sources ranged, depending on the variable, from 85 to 117 never different from 100 (P > 0.05). The coefficients of determination of the regressions were 0.91 in broilers and above 0.89 in piglets. Analysis II: in broilers, bone Zn was explained by supplemental Zn (linear and quadratic, P < 0.001) and by supplemental phytase (linear, P < 0.001). In piglets, the interaction between dietary Zn and phytates/phytases was investigated by means of a new variable combining dietary phytic phosphorus (PP) and phytase activity. This new variable represents the remaining dietary PP after its hydrolysis in the digestive tract, mainly due to phytase and is called non-hydrolyzed phytic phosphorus (PPNH). Bone Zn was increased with native Zn (P < 0.001), but to a lower extent in high PP or low phytase diets (ZNN × PPNH, P < 0.001). In contrast, the increase in bone zinc in response to supplemental Zn (P < 0.001) was not modulated by PPNH (P > 0.05). The coefficients of determination of the regressions were 0.92 in broilers and above 0.92 in piglets. The results from the two meta-analyses suggest that (1) broilers and piglets use supplemented Zn, independent from Zn source; (2) broiler use native Zn and the use is slightly enhanced with supplemental phytase; (3) however, piglets are limited in the use of native Zn because of the antagonism of non-hydrolyzed dietary phytate. This explains the higher efficacy of phytase in improving Zn availability in this specie.

Keywords

zincbroilerpigletphytatephytase
Type
Nutrition
Information
animal , Volume 7 , Issue 1 , January 2013 , pp. 47 - 59
Copyright
Copyright © The Animal Consortium 2012

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References

Ammerman, CB, Baker, DH, Lewis, AJ 1995. Bioavailability of nutrients for animals. Amino acids, minerals and vitamins. Academic Press, San Diego, USA.Google Scholar
Adeola, O 1995. Digestive utilization of minerals by weanling pigs fed copper- and phytase-supplemented diets. Canadian Journal of Animal Science 75, 603–610.CrossRefGoogle Scholar
Ao, T, Pierce, JJ, Power, R, Dawson, KA, Pescatore, AJ, Cantor, AH, Ford, MJ 2006. Evaluation of Bioplex Zn as an organic zinc source for chicks. International Journal of Poultry Science 5, 808–811.Google Scholar
Bao, YM, Choct, M, Iji, PA, Bruerton, K 2007. Effect of organically complexed copper, iron, manganese and zinc on broiler performance, mineral excretion, and accumulation in tissues. Journal of Applied Poultry Research 16, 448–455.Google Scholar
Biehl, RR, Baker, DH, DeLuca, HF 1995. lα-Hydroxylated cholecalciferol compounds act additively with microbial phytase to improve phosphorus, zinc and manganese utilization in chicks fed soy-based diets. Journal of Nutrition 125, 2407–2416.CrossRefGoogle ScholarPubMed
Cao, J, Henry, PR, Davis, SR, Cousins, RJ, Miles, RD, Littell, RC, Ammerman, CB 2002. Relative bioavailability of organic zinc sources based on tissue zinc and metallothionein in chicks fed conventional dietary zinc concentrations. Animal Feed Science and Technology 101, 161–170.CrossRefGoogle Scholar
Cao, J, Henry, PR, Guo, R, Holwerda, RA, Toth, JP, Littell, RC, Miles, RD, Ammerman, CB 2000. Chemical characteristics and relative bioavailability of supplemental organic zinc sources for poultry and ruminants. Journal of Animal Science 78, 2039–2054.CrossRefGoogle ScholarPubMed
Cheng, J, Kornegay, ET, Schell, TC 1998. Influence of dietary lysine on the utilization of zinc from zinc sulfate and a zinc–lysine complex by young pigs. Journal of Animal Science 76, 1064–1074.CrossRefGoogle Scholar
Davies, NT, Nightingale, R 1975. Effects of phytate on intestinal-absorption and secretion of zinc, and whole-body retention of Zn, copper, iron and manganese in rats. British Journal of Nutrition 34, 243–258.CrossRefGoogle ScholarPubMed
Erdman, JW 1979. Oilseed phytates: nutritional implications. Journal of American Oil Chemist Society 56, 736–741.CrossRefGoogle Scholar
Fordyce, EJ, Forbes, RM, Robbins, KR, Erdman, JW 1987. Phytate × calcium/zinc molar ratios: are they predictive of zinc bioavailability. Journal of Food Science 52, 440–444.Google Scholar
Gebert, S, Wenk, C, Messikommer, R 2002. Different zinc sources in the diet for broiler. In Schriftreihe aus dem Institut für Nutztierwissenschaften, Ernährung-Produkte-Umwelt. (ed. M Kreuzer, C Wenk and T Lanzini), pp. 212–215. ETH Zürich, Zürich, Switzerland.Google Scholar
Hill, DA, Peo, ER, Lewis, AJ, Crenshaw, JD 1986. Zinc–amino acid complexes for swine. Journal of Animal Science 63, 121–130.CrossRefGoogle ScholarPubMed
Jondreville, C, Hayler, R, Feuerstein, D 2005. Replacement of zinc sulphate by microbial phytase for piglets given a maize–soya-bean meal diet. Animal Science 81, 77–83.Google Scholar
Jondreville, C, Lescoat, P, Magnin, M, Feuerstein, D, Gruenberg, B, Nys, Y 2007. Sparing effect of microbial phytase on zinc supplementation in maize-soya-bean meal diets for chickens. Animal 1, 804–811.CrossRefGoogle ScholarPubMed
Jongbloed, AW, Kemme, PA, De Groote, G, Lippens, M, Meschy, F 2002. Bioavailability of major and trace minerals. EMFEMA, International Association of the European Manufacturers of Major, Trace and Specific Feed Mineral Materials, Brussels, Belgium.Google Scholar
Kumar, V, Sinha, AK, Makkar, HPS, Becker, K 2010. Dietary roles of phytate and phytase in human nutrition: a review. Food Chemistry 120, 945–959.CrossRefGoogle Scholar
Lease, JG 1963. Availability to the chick of zinc phytate complexes isolated from oil seed meals by an in vitro digestion method. Journal of Nutrition 93, 523–532.Google Scholar
Lee, SH, Choi, SC, Chae, BJ, Acda, SP, Han, YK 2001a. Effects of feeding different chelated copper and zinc sources on growth performance and fecal excretions of weanling pigs. Asian-Australasian Journal of Animal Sciences 14, 1616–1620.CrossRefGoogle Scholar
Lee, SH, Choi, SC, Chae, BJ, Lee, JK, Acda, SP 2001b. Evaluation of metal-amino acid chelates and complexes at various levels of copper and zinc in weanling pigs and broiler chicks. Asian-Australasian Journal of Animal Sciences 14, 1734–1740.CrossRefGoogle Scholar
Lei, XG, Ku, PK, Miller, ER, Ullrey, DE, Yokoyama, MT 1993. Supplemental microbial phytase improves bioavailability of dietary zinc to weanling pigs. Journal of Nutrition 123, 1117–1123.Google Scholar
Létourneau-Montminy, MP 2009. Modélisation du métabolisme phosphocalcique chez le porc et le poulet en croissance. PhD, AgroParisTech, Paris, France and Université Laval, Québec, Canada.Google Scholar
Létourneau-Montminy, MP, Jondreville, C, Sauvant, D, Narcy, A 2012. Meta-analysis of phosphorus utilization by growing pigs: effect of dietary phosphorus, calcium and exogenous phytase. Animal, available on CJO 2012, doi:10.1017/S1751731112000560Google Scholar
Létourneau-Montminy, MP, Narcy, A, Lescoat, P, Magnin, M, Bernier, JF, Sauvant, D, Jondreville, C, Pomar, C 2011. Modeling the fate of dietary phosphorus in the digestive tract of growing pigs. Journal of Animal Science 89, 3596–3611.CrossRefGoogle ScholarPubMed
Létourneau-Montminy, MP, Narcy, A, Lescoat, P, Bernier, JF, Magnin, M, Pomar, C, Nys, Y, Sauvant, D, Jondreville, C 2010. Meta-analysis of phosphorus utilisation by broilers receiving maize–soyabean meal diets: influence of dietary calcium and microbial phytase. Animal 4, 1844–1853.Google Scholar
Linares, LB, Broomhead, JN, Guaiume, EA, Ledoux, DR, Veum, TL, Raboy, V 2007. Effects of low phytate barley (Hordeum vulgare L.) on zinc utilization in young broiler chicks. Poultry Science 86, 299–308.CrossRefGoogle Scholar
Männer, K, Simon, O, Schlegel, P 2006. Effects of different iron, manganese, zinc and copper sources (sulphates, chelates, glycinates) on their bioavailability in early weaned piglets. In 9. Tagung der Schweine- und Geflügelernährung (ed. M. Rodehutscord), pp. 25–27. Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.Google Scholar
Minitab 2007. Minitab version 15.1.1.0 for Windows. Minitab Inc., State College, PA, USA.Google Scholar
Mohanna, C, Nys, Y 1998. Influence of age, sex and cross on body concentrations of trace elements (zinc, iron, copper and manganese) in chickens. British Poultry Science 39, 536–543.Google Scholar
Mohanna, C, Nys, Y 1999a. Effect of dietary zinc content and sources on the growth, body zinc deposition and retention, zinc excretion and immune response in chickens. British Poultry Science 40, 108–114.CrossRefGoogle ScholarPubMed
Mohanna, C, Nys, Y 1999b. Changes in zinc and manganese availability in broiler chicks induced by vegetal and microbial phytase. Animal Feed Science and Technology 77, 241–253.Google Scholar
Mohanna, C, Carré, B, Nys, Y 1999. Incidence of dietary viscosity on growth performance and zinc and manganese bioavailability in broilers. Animal Feed Science and Technology 77, 255–266.Google Scholar
National Research Council (NRC) 1994. Nutrient Requirements of Poultry, 9th revised edition. National Academy Press, Washington, DC, USA.Google Scholar
NRC 1998. Nutrient Requirements of Swine, 10th revised edition. National Academy Press, Washington, DC, USA.Google Scholar
Oberleas, D, Muhrer, ME, O'Dell, BL 1962. Effects of phytic acid on zinc availability and parakeratosis in swine. Journal of Animal Science 21, 57–61.CrossRefGoogle Scholar
O'Dell, BL, Savage, JE 1960. Effect of phytic acid on zinc availability. Proceedings of the Society for Experimental Biology and Medicine 103, 304–306.Google Scholar
Pallauf, J, Höhler, D, Rimbach, G 1992. Effect of microbial phytase supplementation to a maize–soya-diet on the apparent absorption of Mg, Fe, Cu, Mn and Zn and parameters of Zn-status in piglets. Journal of Animal Physiology and Animal Nutrition 68, 1–9.Google Scholar
Pallauf, J, Rimbach, G, Pippig, S, Schindler, B, Höhler, D, Most, E 1994. Dietary effect of phytogenic phytase and an addition of microbial phytase to a diet based on field beans, wheat, peas and barley on the utilization of phosphorus, calcium, magnesium, zinc and protein in piglets. Zeitschrift für Ernährungswissenschaft 33, 128–135.CrossRefGoogle Scholar
Revy, PS, Jondreville, C, Dourmad, JY, Nys, Y 2003. Zinc in pig nutrition: the essential trace element and potential adverse effect on environment. INRA Productions Animales 16, 3–18.CrossRefGoogle Scholar
Revy, PS, Jondreville, C, Dourmad, JY, Nys, Y 2004. Effect of zinc supplemented as either an organic or an inorganic source and of microbial phytase on zinc and other minerals utilisation by weanling pigs. Animal Feed Science and Technology 116, 93–112.CrossRefGoogle Scholar
Revy, PS, Jondreville, C, Dourmad, JY, Nys, Y 2006. Assessment of dietary zinc requirement of weaned piglets fed diets with or without microbial phytase. Journal of Animal Physiology and Animal Nutrition 90, 50–59.Google Scholar
Revy, PS, Jondreville, C, Dourmad, JY, Guinotte, F, Nys, Y 2002. Bioavailability of two sources of zinc in weanling pigs. Animal Research 51, 315–326.Google Scholar
Rimbach, G, Pallauf, J 1992. Effekt einer Zulage mikrobieller Phytase auf die Zinkverfügbarkeit. Zeitschrift für Ernährungswissenschaft 31, 269–277.Google Scholar
Rimbach, G, Pallauf, J, Brandt, K, Most, E 1995. Effect of phytic acid and microbial phytase on Cd accumulation, Zn status, and apparent absorption of Ca, P, Mg, Fe, Zn, Cu, and Mn in growing rats. Annals of Nutrition and Metabolism 39, 361–370.Google Scholar
Rodrigues-Filho, UP, Vaz, S Jr, Felicissimo, MP, Scarpellini, M, Cardoso, DR, Vinhas, RCJ, Landers, R, Schneider, JF, Mc Garvey, BR, Andersen, ML, Skibsted, LH 2005. Heterometallic manganese/zinc–phytate complex as a model compound for metal storage in wheat grains. Journal of Inorganic Biochemistry 99, 1973–1982.Google Scholar
Sandström, B, Almgren, A, Kivistö, B, Cederblad, A 1987. Zinc absorption in humans from meals based on rye, barley, oatmeal, triticale and whole wheat. Journal of Nutrition 117, 1898–1902.Google Scholar
Sauvant, D, Perez, JM, Tran, G (ed.) 2004. Tables of composition and nutritional value of feed materials. Pigs, poultry, cattle, sheep, goats, rabbits, horses, fish. INRA Editions, Paris, France and Wageningen Academic Publishers, Wageningen, The Netherlands.Google Scholar
Sauvant, D, Schmidely, P, Daudin, JJ, St-Pierre, NR 2008. Meta-analyses of experimental data in animal nutrition. Animal 2, 1203–1214.CrossRefGoogle ScholarPubMed
Schlegel, P, Nys, Y, Jondreville, C 2010. Zinc availability and digestive zinc solubility in piglets and broilers fed diets varying in their phytate contents, phytase activity and supplemented zinc source. Animal 4, 200–209.Google Scholar
Schlegel, P, Windisch, W 2006. Bioavailability of zinc glycinate in comparison with zinc sulphate in the presence of dietary phytate in an animal model with 65Zn labelled rats. Journal of Animal Physiology and Animal Nutrition 90, 216–222.CrossRefGoogle Scholar
Selle, PH, Ravindran, V 2007. Microbial phytase in poultry nutrition. Animal Feed Science and Technology 135, 1–41.Google Scholar
Selle, PH, Ravindran, V 2008. Phytate-degrading enzymes in pig nutrition. Livestock Science 113, 99–122.Google Scholar
Susaki, H, Matsui, T, Ashida, KY, Fujita, S, Nakajima, T, Yano, H 1999. Availability of a zinc amino acid chelate for growing pigs. Journal of Animal Science 70, 124–128.Google Scholar
Swiatkiewicz, S, Koreleski, J, Zhong, DQ 2001. The bioavailability of zinc from inorganic and organic sources in broiler chickens as affected by addition of phytase. Journal of Animal and Feed Sciences 10, 317–328.Google Scholar
Swinkels, JWGM, Kornegay, ET, Zhou, W, Lindemann, MD, Webb, KE, Verstegen, MWA 1996. Effectiveness of a zinc amino acid chelate and zinc sulfate in restoring serum and soft tissue zinc concentrations when fed to zinc-depleted pigs. Journal of Animal Science 74, 2420–2430.Google Scholar
Systat 2007. Systat version 12.00.08 for Windows. SYSTAT Software Inc., Chicago, IL, USA.Google Scholar
Wedekind, KJ, Hortin, AE, Baker, DH 1992. Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulfate and zinc oxide. Journal of Animal Science 70, 178–187.CrossRefGoogle ScholarPubMed
Wedekind, KJ, Lewis, AJ, Giesemann, MA, Miller, PS 1994. Bioavailability of zinc from inorganic and organic sources for pigs fed corn–soybean meal diets. Journal of Animal Science 72, 2681–2689.Google Scholar
Windisch, W, Kirchgessner, M 1999. Zn absorption and excretion in adult rats at Zn deficiency induced by dietary phytate additions. Journal of Animal Physiology and Animal Nutrition 82, 106–115.CrossRefGoogle Scholar
Windisch, W 2001. Homeostatic reactions of quantitative Zn metabolism on deficiency and subsequent repletion with Zn in 65Zn labeled adult rats. Trace Elements and Electrolytes 18, 133–128.Google Scholar
Zacharias, B, Pelletier, W, Drochner, W 2004. Organic copper and zinc in diets for growing pigs – a possibility to reduce environmental pollution with copper and zinc. In Proceedings of the 13th conference on nutrition of domestic animals (ed. A Pen), pp. 257–265. Kmetijsko gozdarski zavod, Muska Sobota, Slovenia.Google Scholar