Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-27T06:17:13.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Characterization of Osteopontin gene of Bubalus bubalis

Published online by Cambridge University Press:  01 July 2008

M. S. Tantia ,
B. Mishra ,
S. T. Bharani Kumar ,
B. P. Mishra ,
R. S. Kataria ,
M. Mukesh  and
R. K. Vijh
M. S. Tantia
Affiliation:
National Bureau of Animal Genetic Resources, Karnal, Haryana, India
B. Mishra
Affiliation:
National Bureau of Animal Genetic Resources, Karnal, Haryana, India
S. T. Bharani Kumar
Affiliation:
National Bureau of Animal Genetic Resources, Karnal, Haryana, India
B. P. Mishra
Affiliation:
National Bureau of Animal Genetic Resources, Karnal, Haryana, India
R. S. Kataria
Affiliation:
National Bureau of Animal Genetic Resources, Karnal, Haryana, India
M. Mukesh
Affiliation:
National Bureau of Animal Genetic Resources, Karnal, Haryana, India
R. K. Vijh*
Affiliation:
National Bureau of Animal Genetic Resources, Karnal, Haryana, India
*
E-mail: rameshvijh@yahoo.com
Get access

Abstract

Osteopontin, a glycoprotein, is expressed in several tissues including the mammary gland. The gene has been reported to be associated with milk and its constituents in various livestock species. This gene was sequenced in buffalo and it coded for the protein of 280 amino acids with the conserved GRGDS domain. The sequence was confirmed from the cDNA sequence derived from the mammary gland of buffalo. The earlier-reported 9T/10T variation in the upstream region of the gene was investigated for its effect on milk in buffalo and it was found to be non-significant.

Keywords

buffalogeneosteopontinSPP1sequence
Type
Full Paper
Information
animal , Volume 2 , Issue 7 , July 2008 , pp. 987 - 990
Copyright
Copyright © The Animal Consortium 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ashwell, MS, Heyen, DW, Sonstegard, TS, Van Tassell, CP, Da, Y, VanRaden, PM, Ron, M, Weller, JI, Lewin, HA 2004. Detection of quantitative trait loci affecting milk production, health, and reproductive traits in Holstein cattle. Journal of Dairy Science 87, 468–475.CrossRefGoogle ScholarPubMed
Cohen, M, Seroussi, E, Larkin, DM, Loor, JJ, Everts-van der, W, Heon-Lee, J, Drackley, JK, Band, MR, Hernandez, AG, Shani, M, Lewin, HA, Weller, JI, Ron, M 2005. Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Research 15, 936–944.CrossRefGoogle Scholar
Crivello, JF, Delvin, E 1992. Isolation and characterization of a cDNA for osteopontin-k, a kidney cell adhesion molecule with high homology to osteopontins. Journal of Bone and Mineral Research 7, 693–699.CrossRefGoogle ScholarPubMed
De Koning, DJ 2006. Conflicting candidates for cattle QTLs. Trends in Genetics 22, 301–305.CrossRefGoogle ScholarPubMed
Denhardt, DT, Guo, X 1993. Osteopontin: a protein with diverse functions. The FASEB journal: official publication of the Federation of American Societies for Experimental Biology 7, 1475–1482.CrossRefGoogle ScholarPubMed
Harvey, WR 1990. User’s guide for LSMLMW and MIXMDL. Ohio State University, Columbus, OH, USA.Google Scholar
Khatib, H, Zaitoun, I, Wiebelhaus-Finger, J, Chang, YM, and Rosa, GJM 2007. The Association of Bovine PPARGC1A and OPN Genes with Milk Composition in Two Independent Holstein Cattle Populations. Journal of Dairy Science 90, 2966–2970.CrossRefGoogle ScholarPubMed
Leonard, S, Khatib, H, Schutzkus, V, Chang, YM, Maltecca, C 2005. Effects of the Osteopontin gene variants on milk production traits in dairy cattle. Journal of Dairy Science 88, 4083–4086.CrossRefGoogle ScholarPubMed
Nadesalingam, J, Plante, Y, Gibson, JP 2001. Detection of QTL for milk production on chromosomes 1 and 6 of Holstein cattle. Mammalian Genome 12, 27–31.CrossRefGoogle ScholarPubMed
Nagatomo, T, Ohga, S, Takada, H, Nomura, A, Hikino, S, Imura, M, Ohshima, K, Hara, T 2004. Microarray analysis of human milk cells: Persistent high expression of osteopontin during the lactation period. Clinical and Experimental Immunology 138, 47–53.CrossRefGoogle ScholarPubMed
Nemir, M, Bhattacharyya, D, Li, X, Singh, K, Mukherjee, AB, Mukherjee, BB 2000. Targeted inhibition of Osteopontin expression in the mammary gland causes abnormal morphogenesis and lactation deficiency. Journal of Biological Chemistry 275, 969–976.CrossRefGoogle ScholarPubMed
Olsen, HG, Lien, S, Svendsen, M, Nilsen, H, Roseth, A, Opsal, MA, Meuwissen, THE 2004. Fine mapping of milk production QTL on BTA6 by combined linkage and linkage disequilibrium analysis. Journal of Dairy Science 87, 690–698.CrossRefGoogle ScholarPubMed
Olsen, HG, Nilsen, H, Hayes, B, Berg, PR, Svendsen, M, Lien, S, Meuwissen, THE 2007. Genetic support for a quantitative trait nucleotide in the ABCG2 gene affecting milk composition of dairy cattle. BMC Genetics 8, 32. doi: 10.1186/1471-2156-8-32.CrossRefGoogle ScholarPubMed
Ron, M, Kliger, D, Feldmesser, E, Seroussi, E, Ezra, E, Weller, JI 2001. Multiple quantitative trait locus analysis of bovine chromosome 6 in the Israeli Holstein population by a daughter design. Genetics 159, 727–735.CrossRefGoogle ScholarPubMed
Schnabel, RD, Kim, J, Ashwell, MS, Sonstegard, TS, Tassell, CPV, Connor, EE, Taylor, JF 2005. Fine-mapping milk production quantitative trait loci on BTA6: Analysis of the bovine osteopontin gene. Proceedings of the National Academy of Sciences of the United States of America 102, 6896–6901.CrossRefGoogle ScholarPubMed
Tantia, MS, Vijh, RK, Mishra, BP, Mishra, B, Bharani Kumar, ST, Sodhi, M 2006. DGAT1 and ABCG2 polymorphism in Indian cattle (Bos indicus) and buffalo (Bubalus bubalis) breeds. BMC Veterinary Research 2, 32. doi: 10.1186/1746-6148-2-32.CrossRefGoogle ScholarPubMed
Zhang, Q, Boichard, D, Hoeschele, I, Ernst, C, Eggen, A, Murkve, B, Pfister-Genskow, M, Witte, LA, Grignola, FE, Uimari, P, Thaller, G, Bishop, MD 1998. Mapping QTL for milk production and health of dairy cattle in a large outbred pedigree. Genetics 149, 1959–1973.CrossRefGoogle Scholar