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Effects of guanidinoacetic acid supplementation on growth performance, nutrient digestion, rumen fermentation and blood metabolites in Angus bulls

Published online by Cambridge University Press:  25 June 2020

S. Y. Li ,
C. Wang ,
Z. Z. Wu ,
Q. Liu Open the ORCID record for Q. Liu [Opens in a new window] ,
G. Guo ,
W. J. Huo ,
J. Zhang ,
L. Chen ,
Y. L. Zhang  and
C. X. Pei
...Show all authors
S. Y. Li
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
C. Wang
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
Z. Z. Wu
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
Q. Liu*
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
G. Guo
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
W. J. Huo
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
J. Zhang
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
L. Chen
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
Y. L. Zhang
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
C. X. Pei
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
S. L. Zhang
Affiliation:
College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, Shanxi Province, P. R. China
*
†E-mail: liuqiangabc@163.com
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Abstract

Guanidinoacetic acid (GAA) can improve the growth performance of bulls. This study investigated the influences of GAA addition on growth, nutrient digestion, ruminal fermentation and serum metabolites in bulls. Forty-eight Angus bulls were randomly allocated to experimental treatments, that is, control, low-GAA (LGAA), medium-GAA (MGAA) and high-GAA (HGAA), with GAA supplementation at 0, 0.3, 0.6 and 0.9 g/kg DM, respectively. Bulls were fed a basal diet containing 500 g/kg DM concentrate and 500 g/kg DM roughage. The experimental period was 104 days, with 14 days for adaptation and 90 days for data collection. Bulls in the MGAA and HGAA groups had higher DM intake and average daily gain than bulls in the LGAA and control groups. The feed conversion ratio was lowest in MGAA and highest in the control. Bulls receiving 0.9 g/kg DM GAA addition had higher digestibility of DM, organic matter, NDF and ADF than bulls in other groups. The digestibility of CP was higher for HGAA than for LGAA and control. The ruminal pH was lower for MGAA, and the total volatile fatty acid concentration was greater for MGAA and HGAA than for the control. The acetate proportion and acetate-to-propionate ratio were lower for MGAA than for LGAA and control. The propionate proportion was higher for MGAA than for control. Bulls receiving GAA addition showed decreased ruminal ammonia N. Bulls in MGAA and HGAA had higher cellobiase, pectinase and protease activities and Butyrivibrio fibrisolvens, Prevotella ruminicola and Ruminobacter amylophilus populations than bulls in LGAA and control. However, the total protozoan population was lower for MGAA and HGAA than for LGAA and control. The total bacterial and Ruminococcus flavefaciens populations increased with GAA addition. The blood level of creatine was higher for HGAA, and the activity of l-arginine glycine amidine transferase was lower for MGAA and HGAA, than for control. The blood activity of guanidine acetate N-methyltransferase and the level of folate decreased in the GAA addition groups. The results indicated that dietary addition of 0.6 or 0.9 g/kg DM GAA improved growth performance, nutrient digestion and ruminal fermentation in bulls.

Keywords

guanidinoacetateweight gainnutrient digestibilityrumen microflorablood indicators
Type
Research Article
Information
animal , Volume 14 , Issue 12 , December 2020 , pp. 2535 - 2542
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Animal Consortium

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References

Agarwal, N, Kamra, DN, Chaudhary, LC, Agarwal, I, Sahoo, A and Pathak, NN 2002. Microbial status and rumen enzyme profile of crossbred calves fed on different microbial feed additives. Letters in Applied Microbiology 34, 329–336.CrossRefGoogle ScholarPubMed
Allen, MS 2000. Effects of diet on short-term regulation of feed intake by lactating dairy cattle. Journal of Dairy Science 83, 1598–1624.Google ScholarPubMed
Alvarado-Ramirez, E, Torres-Rodriguez, JM, Sellart, M and Vidotto, V 2008. Laccase activity in Cryptococcus gattii strains isolated from goats. Revista Iberoamericana de Micología 25, 150–153.Google ScholarPubMed
Amiri, M, Ghasemi, HA, Hajkhodadadi, I and Farahani, AHK 2019. Efficacy of guanidinoacetic acid at different dietary crude protein levels on growth performance, stress indicators, antioxidant status, and intestinal morphology in broiler chickens subjected to cyclic heat stress. Animal Feed Science and Technology 254, 114208.Google Scholar
Association of Official Analytical Chemists (AOAC) 1997. Official methods of analysis, 16th edition. Association of Official Analytical Chemists, Gaithersburg, MD, USA.Google Scholar
Association of Official Analytical Chemists (AOAC) 2000. Official methods of analysis, 17th edition. Association of Official Analytical Chemists, Arlington, VA, USA.Google Scholar
Ardalan, M, Miesner, MD, Reinhardt, CD, Thomson, DU, Armendariz, CK and Titgemeyer, EC 2016. Guanidinoacetic acid as a precursor for creatine in steers. Journal of Animal Science (E-suppl. 5), 753–754. (Abstr.)Google Scholar
Bailey, LB and Gregory, JF 1999. Folate metabolism and requirements. Journal of Nutrition 129, 779–782.CrossRefGoogle ScholarPubMed
Brosnan, JT and Brosnan, ME 2010. Creatine metabolism and the urea cycle. Molecular Genetics and Metabolism 100, S49–S52.CrossRefGoogle ScholarPubMed
Castillo-Gonzalez, AR, Burrola-Barraza, ME, Dominguez-Viveros, J and Chavez-Martinez, A 2014. Rumen microorganisms and fermentation. Archivos De Medicina Veterinaria 46, 349–361.CrossRefGoogle Scholar
Duskova, D and Marounek, M 2001. Fermentation of pectin and glucose, and activity of pectin-degrading enzymes in the rumen bacterium Lachnospira multiparus. Letters in Applied Microbiology 33, 159–163.CrossRefGoogle ScholarPubMed
Faraji, M, Dehkordi, SK, Moghadam, AKZ, Ahmadipour, B and Khajali, F 2018. Combined effects of guanidinoacetic acid, coenzyme Q10 and taurine on growth performance, gene expression and ascites mortality in broiler chickens. Journal of Animal Physiology and Animal Nutrition 00, 1–8.Google Scholar
Ferret, A, Plaixats, J, Caja, G, Gasa, J and Prió, P 1999. Using markers to estimate apparent dry matter digestibility, faecal output and dry matter intake in dairy ewes fed Italian ryegrass hay or alfalfa hay. Small Ruminant Research 33, 145–152.CrossRefGoogle Scholar
Firkins, JL, Yu, Z and Morrison, M 2007. Ruminal nitrogen metabolism: perspectives for integration of microbiology and nutrition for dairy. Journal of Dairy Science 90, E1–E16.CrossRefGoogle ScholarPubMed
Galbraith, RA, Furukawa, M and Li, M 2006. Possible role of creatine concentrations in the brain in regulating appetite and weight. Brain Research 1101, 85–91.CrossRefGoogle ScholarPubMed
Kongmun, P, Wanapat, M, Pakdee, P and Navanukraw, C 2010. Effect of coconut oil and garlic powder on in vitro fermentation using gas production technique. Livestock Science 127, 38–44.CrossRefGoogle Scholar
Li, JL, Zhang, L, Fu, YA, Li, YJ, Jiang, Y, Zhou, GH and Gao, F 2018. Creatine monohydrate and guanidinoacetic acid supplementation affect the growth performance, meat quality and creatine metabolism of finishing pigs. Journal of Agricultural and Food Chemistry 86, 9952–9959.CrossRefGoogle Scholar
Miller, GL 1959. Use of dinitrosalicylic acid reagent for determination of reducing sugar. Analytical Chemistry 31, 426–428.CrossRefGoogle Scholar
NRC 2001. Nutrient requirements of dairy cattle, 7th revised edition. The National Academy Press, Washington, DC, USA.Google Scholar
Oba, M and Allen, MS 2003. Effects of diet fermentability on efficiency of microbial nitrogen production in lactating dairy cows. Journal of Dairy Science 86, 195–207.CrossRefGoogle ScholarPubMed
Ostojic, SM 2015. Advanced physiological roles of guanidinoacetic acid. European Journal of Nutrition 54, 211–1215.CrossRefGoogle ScholarPubMed
Reynolds, CK and Kristensen, NB 2008. Nitrogen recycling through the gut and the nitrogen economy of ruminants: an asynchronous symbiosis. Journal of Animal Science 86, E293–E305.CrossRefGoogle ScholarPubMed
SAS (Statistics Analysis System) 2002. User’s guide: statistics, version 9th edition. Statistical Analysis Systems Institute, Cary, NC, USA.Google Scholar
Speer, HF 2019. Efficacy of guanidinoacetic acid supplementation to growing cattle and relative bioavailability of guanidinoacetic acid delivered ruminally or abomasally. Master’s thesis, Kansas State University, Manhattan, KU, USA.CrossRefGoogle Scholar
Trinci, APJ, Davies, DR, Gull, K, Lawrence, MI, Nielsen, BB, Rickers, A and Theodorou, MK 1994. Anaerobic fungi in herbivorous animals. Mycological Research 98, 129–152.CrossRefGoogle Scholar
Van Soest, PJ, Robertson, JB and Lewis, BA 1991. Methods for dietary fiber, neutral detergent fiber and non-starch polysaccharides in relation to animal nutrition. Journal of Dairy Science 74, 3583–3597.Google Scholar
Wales, WJ, Kolver, ES, Thorne, PL and Egan, AR 2004. Diurnal variation in ruminal pH on the digestibility of highly digestible perennial ryegrass during continuous culture fermentation. Journal of Dairy Science 87, 1864–1871.CrossRefGoogle ScholarPubMed
Wallimann, T, Tokarska-Schlattner, M and Schlattner, U 2011. The creatine kinase system and pleiotropic effects of creatine. Amino Acids 40, 1271–1296.Google ScholarPubMed
Wang, Y and Mcallister, TA 2002. Rumen microbes, enzymes and feed digestion - a review. Asian-Australasian Journal of Animal Sciences 15, 1659–1676.CrossRefGoogle Scholar
Wang, Y, Ma, JD, Qiu, WL, Zhang, JW, Feng, SY, Zhou, XK, Wang, X, Jin, L, Long, KR, Liu, LY, Xiao, WH, Tang, QZ, Zhu, L, Jiang, YZ, Li, XW and Li, MZ 2018. Guanidinoacetic acid regulates myogenic differentiation and muscle growth through miR-133a-3p and miR-1a-3p co-mediated Akt/mTOR/S6K signaling pathway. International Journal of Molecular Sciences 19, 2837–2856.CrossRefGoogle ScholarPubMed
Williams, CH, David, DJ and Iismaa, O 1962. The determination of chromic oxide in faeces samples by atomic absorption spectrophotometry. Journal of Agricultural Science 59, 381–385.CrossRefGoogle Scholar
Wyss, M and Kaddurah-Daouk, R 2000. Creatine and creatinine metabolism. Physiological Reviews 80, 1107–1213.CrossRefGoogle ScholarPubMed
Young, JF, Bertram, HC, Theil, PK, Petersen, AGD, Poulsen, KA, Rasmussen, M, Malmendal, A, Nielsen, NC, Vestergaard, M and Oksbjerg, N 2007. In vitro and in vivo studies of creatine monohydrate supplementation to Duroc and Landrace pigs. Meat Science 76, 342–351.CrossRefGoogle ScholarPubMed
Yu, Z and Morrison, M 2004. Improved extraction of PCR-quality community DNA from digesta and fecal sample. BioTechniques 36, 808–812.CrossRefGoogle Scholar