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The missing developmental dimension in the network perspective

Published online by Cambridge University Press:  29 June 2010

Sam Wass
Affiliation:
Centre for Brain and Cognitive Development, Birkbeck College, University of London, London WC1E 7HX, United Kingdom. samwass@gmail.comhttp://www.cbcd.bbk.ac.uk/people/students/sama.karmiloff-smith@bbk.ac.ukhttp://www.psyc.bbk.ac.uk/research/DNL/personalpages/annette.html
Annette Karmiloff-Smith
Affiliation:
Centre for Brain and Cognitive Development, Birkbeck College, University of London, London WC1E 7HX, United Kingdom. samwass@gmail.comhttp://www.cbcd.bbk.ac.uk/people/students/sama.karmiloff-smith@bbk.ac.ukhttp://www.psyc.bbk.ac.uk/research/DNL/personalpages/annette.html

Abstract

We welcome network theory as a tool for modelling the multi-directional interactions that characterise disease. However, we feel that Cramer et al. have neglected one important aspect: how diseases change over developmental time. We discuss principles such as fan in, fan out, bottlenecks, and common pathways, and argue that modelling these developmental aspects can be vital, particularly in deriving properly targeted treatments.

Type
Open Peer Commentary
Copyright
Copyright © Cambridge University Press 2010

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