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Association of fatty acids in serum phospholipids with hay fever, specific and total immunoglobulin E

Published online by Cambridge University Press:  08 March 2007

Iris Kompauer ,
Hans Demmelmair ,
Berthold Koletzko ,
Gabriele Bolte ,
Jakob Linseisen  and
Joachim Heinrich
Iris Kompauer
Affiliation:
GSF – National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
Hans Demmelmair
Affiliation:
Dr von Haunersches Kinderspital, Division of Metabolic Disorders and Nutrition, Munich, Germany
Berthold Koletzko
Affiliation:
Dr von Haunersches Kinderspital, Division of Metabolic Disorders and Nutrition, Munich, Germany
Gabriele Bolte
Affiliation:
Bavarian Health and Food Safety Authority, Department of Environmental Health, Oberschleissheim, Germany
Jakob Linseisen
Affiliation:
Unit of Human Nutrition and Cancer Prevention, TU, Munich, Germany Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany
Joachim Heinrich*
Affiliation:
GSF – National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
*
*Corresponding author: Dr Joachim Heinrich, fax +49 89 3187 3380, email joachim.heinrich@gsf.de
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Abstract

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The dietary intake of certain fatty acids might contribute to the development of allergic diseases such as hay fever and asthma. We investigated the association between the concentrations of fifteen fatty acids in serum phospholipids, as a marker of dietary intake and metabolism, and hay fever, allergic sensitisation and total IgE in adults. Data from a population-based cross-sectional study on respiratory health, including the measurement of fatty acids in the serum phospholipids of 740 adults between 20 and 64 years of age, were analysed. Positive associations were found between hay fever and arachidonic acid, and allergic sensitisation and oleic acid. No other fatty acids showed any association with hay fever or allergic sensitisation. Elevated levels of total IgE were not related to fatty acids. Concentrations of long-chain n-3 fatty acids, trans fatty acids or saturated fatty acids in serum phospholipids were not associated with allergic diseases in adults in this study. The present result on the association between hay fever and arachidonic acid is consistent with current hypotheses but warrants further research.

Keywords

Allergic rhinitisSensitisationTotal IgEFatty acidsPhospholipidsEuropean Community Respiratory Health Survey
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 4 , April 2005 , pp. 529 - 535
Copyright
Copyright © The Nutrition Society 2005

References

Arab, L (2003) Biomarkers of fat and fatty acid intake. J Nutr 133, 925S–932S.CrossRefGoogle ScholarPubMed
Black, PN (1999) The prevalence of allergic disease and linoleic acid in the diet. J Allergy Clin Immunol 103, 351–352.CrossRefGoogle ScholarPubMed
Black, PN & Sharpe, S (1997) Dietary fat and asthma: is there a connection?. Eur Respir J 10, 6–12.CrossRefGoogle ScholarPubMed
Burney, PGJ, Luczynska, C, Chinn, S & Jarvis, D (1994) The European Community Respiratory Health Survey. Eur Respir J 7, 954–960.CrossRefGoogle ScholarPubMed
Calder, PC (2003) N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 38, 343–352.CrossRefGoogle ScholarPubMed
Calder, PC & Miles, EA (2000) Fatty acids and atopic disease. Pediatr Allergy Immunol 13 Suppl. 29–36.CrossRefGoogle Scholar
Decsi, T & Koletzko, B (1995) Do trans fatty acids impair linoleic acid metabolism in children?. Ann Nutr Metab 39, 36–41.CrossRefGoogle ScholarPubMed
Gibney, MJ & Hunter, B (1993) The effects of short- and long-term supplementation with fish oil on the incorporation of n -3 polyunsaturated fatty acids into cells of the immune system in healthy volunteers. Eur J Clin Nutr 47, 255–259.Google Scholar
Heinrich, J, Hoelscher, B, Bolte, G & Winkler, G (2001) Allergic sensitization and diet: ecological analysis in selected European cities. Eur Respir J 17, 395–402.CrossRefGoogle ScholarPubMed
Huang, SL, Lin, KC & Pan, WH (2001) Dietary factors associated with physician-diagnosed asthma and allergic rhinitis in teenagers: analyses of the first Nutrition and Health Survey in Taiwan. Clin Exp Allergy 31, 259–264.CrossRefGoogle ScholarPubMed
Hulshof, KFAM, van Erp-Baart, MA & Anttolainen, M (1999) Intake of fatty acids in Western Europe with emphasis on trans fatty acids: the TRANSFAIR study. Eur J Clin Nutr 53, 143–157.CrossRefGoogle ScholarPubMed
Jones, AC, Miles, EA, Warner, JO, Colwell, BM, Bryant, TN & Warner, JA (1996) Fetal peripheral blood mononuclear cell proliferative responses to mitogenic and allergenic stimuli during gestation. Pediatr Allergy Immunol 7, 109–116.CrossRefGoogle ScholarPubMed
Kankaanpää, P, Sütas, Y, Salminen, S, Lichtenstein, A & Isolauri, E (1999) Dietary fatty acids and allergy. Ann Med 31, 282–287.CrossRefGoogle ScholarPubMed
Kew, S, Mesa, MD, Tricon, S, Buckley, R, Minihane, AM & Yaqoob, P (2004) Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans. Am J Clin Nutr 79, 674–681.CrossRefGoogle Scholar
Kolarovic, L & Fournier, NC (1986) A comparison of extraction methods for the isolation of phospholipids from biological sources. Anal Biochem 156, 244–250.CrossRefGoogle ScholarPubMed
Koletzko, B (1992) Trans fatty acids may impair biosynthesis of long chain polyunsaturates and growth in man. Acta Paediatr 81, 302–306.CrossRefGoogle ScholarPubMed
Kompauer, I, Demmelmair, H, Koletzko, B, Bolte, G, Linseisen, J & Heinrich, J (2004) N6/n3 hypothesis and allergies: biologically plausible, but not confirmed. Eur J Med Res 9, 378–382.Google Scholar
Larqué, E, Zamora, S & Gil, A (2001) Dietary trans fatty acids in early life: a review. Early Hum Dev 65 Suppl. S31–S41.CrossRefGoogle ScholarPubMed
Leichsenring, M, Kochsiek, U & Paul, K (1995) ( n -6)-Fatty acids in plasma lipids of children with atopic bronchial asthma. Pediatr Allergy Immunol 6, 209–212.CrossRefGoogle ScholarPubMed
Ma, J, Folsom, AR, Shahar, E & Eckfeldt, JH (1995) Plasma fatty acid composition as an indicator of habitual dietary fat intake in middle-aged adults. Am J Clin Nutr 62, 564–571.CrossRefGoogle ScholarPubMed
Meijer, GW, van Tol, A, van Berkel, TJC & Weststrate, JA (2001) Effect of dietary elaidic versus vaccenic acid on blood and liver lipids in the hamster. Atherosclerosis 157, 31–40.CrossRefGoogle ScholarPubMed
Mihrshahi, S, Peat, JK, Marks, GB, Mellis, CM, Tovey, ER, Webb, K, Britton, WJ & Leeder, SR (2003) Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the Childhood Asthma Prevention Study (CAPS). J Allergy Clin Immunol 111, 162–168.CrossRefGoogle ScholarPubMed
Mozaffarian, D, Pischon, T, Hankinson, SE, Rifai, N, Joshipura, K, Willett, WC & Rimm, EB (2004) Dietary intake of trans fatty acids and systemic inflammation in women. Am J Clin Nutr 79, 606–612.CrossRefGoogle ScholarPubMed
Nafstad, P, Nystad, W, Magnus, P & Jaakkola, JJ (2003) Asthma and allergic rhinitis at 4 years of age in relation to fish consumption in infancy. J Asthma 40, 343–348.CrossRefGoogle ScholarPubMed
Nagel, G, Nieters, A, Becker, N & Linseisen, J (2003) The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. Allergy 58, 1277–1284.CrossRefGoogle ScholarPubMed
Nowak, D, Heinrich, J & Jorres, R (1996) Prevalence of respiratory symptoms, bronchial hyperresponsiveness and atopy among adults: west and east Germany. Eur Respir J 9, 2541–2552.CrossRefGoogle ScholarPubMed
Sanders, TAB (2000) Polyunsaturated fatty acids in the food chain in Europe. Am J Clin Nutr 71 Suppl. 176S – 178SCrossRefGoogle ScholarPubMed
Seaton, A, Godden, DJ & Brown, K (1994) Increase in asthma: a more toxic environment or a more susceptible population?. Thorax 49, 171–174.CrossRefGoogle ScholarPubMed
Semma, M (2002) Trans fatty acids: properties, benefits and risks. J Health Sci 48, 7–13.CrossRefGoogle Scholar
Simopoulos, AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56, 365–379.CrossRefGoogle ScholarPubMed
Trak-Fellermeier, MA, Brasche, S, Winkler, G, Koletzko, B & Heinrich, J (2004) Food and fatty acid intake and atopic disease in adults. Eur Respir J 23, 575–582.CrossRefGoogle ScholarPubMed
von Schacky, C, Fischer, S & Weber, PC (1985) Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. J Clin Invest 76, 1626–1631.CrossRefGoogle ScholarPubMed
Wakai, K, Okamoto, K, Tamakoshi, A, Lin, Y, Nakayama, T & Ohno, Y (2001) Seasonal allergic rhinoconjunctivitis and fatty acid intake: a cross-sectional study in Japan. Ann Epidemiol 11, 59–64.CrossRefGoogle ScholarPubMed
Weiland, SK, von Mutius, E, Huesing, A & Asher, MI (1999) Intake of trans fatty acids and prevalence of childhood asthma and allergies in Europe. Lancet 353, 2040–2041.CrossRefGoogle ScholarPubMed
Woods, RK, Raven, JM, Walters, EH, Abramson, MJ & Thien, FCK (2004) Fatty acid levels and risk of asthma in young adults. Thorax 59, 105–110.CrossRefGoogle ScholarPubMed
Woods, RK, Thien, FCK & Abramson, MJ (2003) Dietary marine fatty acids (fish oil) for asthma in adults and children (Cochrane review) Issue 2 Oxford Update SoftwareGoogle Scholar
Yu, G, Björkstén, B (1998) Polyunsaturated fatty acids in school children in relation to allergy and serum IgE levels. Pediatr Allergy Immunol 9, 133–138.CrossRefGoogle ScholarPubMed
Zeleniuch-Jacquotte, A, Chajes, V, van Kappel, AL, Riboli, E & Toniolo, P (2000) Reliability of fatty acid composition in human serum phospholipids. Eur J Clin Nutr 54, 367–372.CrossRefGoogle ScholarPubMed