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Background diet influences the anti-inflammatory effect of α-linolenic acid in dyslipidaemic subjects

Published online by Cambridge University Press:  09 March 2007

George K. Paschos ,
Loukianos S. Rallidis ,
Georgios K. Liakos ,
Demosthenes Panagiotakos ,
George Anastasiadis ,
Vasilios Votteas  and
Antonis Zampelas
George K. Paschos
Affiliation:
Department of Nutrition and Dietetics, Harokopio University, 70 El Venizelou Street, Athens 17671, Greece
Loukianos S. Rallidis
Affiliation:
Second Department of Cardiology, General Hospital of Nikea, Piraeus, Greece
Georgios K. Liakos
Affiliation:
Biochemistry Laboratory, General Hospital of Nikea, Piraeus, Greece
Demosthenes Panagiotakos
Affiliation:
Department of Nutrition and Dietetics, Harokopio University, 70 El Venizelou Street, Athens 17671, Greece
George Anastasiadis
Affiliation:
Department of Cardiology, Laiko Hospital, Athens, Greece
Vasilios Votteas
Affiliation:
Department of Cardiology, Laiko Hospital, Athens, Greece
Antonis Zampelas*
Affiliation:
Department of Nutrition and Dietetics, Harokopio University, 70 El Venizelou Street, Athens 17671, Greece
*
*Corresponding author: Dr Antonis Zampelas, fax +30 210 9549141, email azampelas@hua.gr
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Abstract

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Long-chain n-3 PUFA from fish oils are known to have anti-inflammatory effects. We evaluated the effect of α-linolenic acid (ALA), precursor of n-3 fatty acids, on serum inflammatory markers and soluble cellular adhesion molecules (sCAM) of dyslipidaemic males, relative to their background diet. Participants were assigned to two groups, based upon food intake patterns: (a) twenty-one dyslipidaemic subjects who habitually ate a Mediterranean–Cretan-type diet; (b) nineteen dyslipidaemic subjects who normally ate a Westernised Greek diet. All were supplemented with 8·1 g ALA/d for 12 weeks. We determined serum amyloid A (SAA), C-reactive protein (CRP), macrophage colony-stimulating factor (MCSF), IL-6, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 and soluble E-selectin concentrations at the beginning and the end of the ALA supplementation period. Serum baseline concentrations of inflammatory markers and sCAM were similar across the diet groups. Type of diet had a significant impact on the response of inflammatory markers to ALA supplementation. The Westernised Greek diet group showed a reduction in SAA (P<0·001), CRP (P=0·002), MCSF (P=0·005) and IL-6 (P=0·04) concentrations. The Mediterranean–Cretan-type background diet group showed a significant reduction only in MCSF concentrations (P=0·003). The sVCAM-1 concentrations were significantly reduced in both the Westernised Greek diet group (P=0·001) and the Mediterranean–Cretan-type diet group (P<0·001). The present study demonstrated that ALA supplementation lowered the serum concentrations of inflammatory markers more profoundly when the background diet was rich in saturated fatty acids and poor in MUFA.

Keywords

α-Linolenic acidMediterranean dietInflammatory markersCellular adhesion molecules
Type
Review Article
Information
British Journal of Nutrition , Volume 92 , Issue 4 , October 2004 , pp. 649 - 655
Copyright
Copyright © The Nutrition Society 2004

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