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Bile acid conjugation and hepatic taurine concentration in rats fed on pectin

Published online by Cambridge University Press:  09 March 2007

T. Ide ,
M. Horii ,
K. Kawashima  and
T. Yamamoto
T. Ide
Affiliation:
Laboratory of Nutrition Chemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, 305 Japan
M. Horii
Affiliation:
Laboratory of Nutrition Chemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, 305 Japan
K. Kawashima
Affiliation:
Laboratory of Nutrition Chemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, 305 Japan
T. Yamamoto
Affiliation:
Laboratory of Nutrition Chemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba Science City, 305 Japan
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Abstract

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A relationship between bile acid conjugation and hepatic taurine concentration was investigated in rats fed on citrus pectin. When rats were fed on the diets containing varying amounts of pectin (10, 30, 60 and 100 g/kg dietary levels), biliary excretion of bile acids increased as the dietary levels of pectin increased. The increase was entirely due to the glycine-conjugated bile acids. The biliary excretion of taurine-conjugated bile acid was somewhat decreased as the dietary level of the fibre increased. Consequently, most of the bile acids were conjugated with glycine in rats fed on the diet containing 100 g pectin/kg. On the other hand, dietary cellulose (60 and 100 g/kg) did not affect the biliary bile acid excretions. The major proportion of bile acids in rats receiving a fibre-free diet and the diets containing cellulose were conjugated with taurine. Hepatic taurine concentrations decreased as the dietary levels of pectin, but not of cellulose, increased. Although dietary pectin (100 g/kg) also slightly decreased the taurine concentration in the kidney, those concentrations in other non-hepatic tissues examined (heart, brain and serum) were unaffected by the dietary fibre. Supplementation of the diet containing 100 g pectin/kg with methionine (10 g/kg) and taurine (10 and 50 g/kg) strikingly increased hepatic taurine concentrations. In this situation, the conjugation of bile acid with glycine was almost abolished and taurine conjugates became abundant in the bile of these animals. It is suggested that dietary pectin mediated an increase in the biliary bile acid excretion which may have depleted the hepatic pool of taurine available for bile acid conjugation and, thus, increased glycine conjugation of bile acids.

Keywords

Bile acid conjugationPectinTaurineRat
Type
Gastrointestinal Physiology, Digestion and Metabolism: Non-Ruminants
Information
British Journal of Nutrition , Volume 62 , Issue 3 , November 1989 , pp. 539 - 550
Copyright
Copyright © The Nutrition Society 1989

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