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Biliary lipids, bile acids and gallstone formation in hypovitaminotic C guinea-pigs

Published online by Cambridge University Press:  09 March 2007

S. A. Jenkins
S. A. Jenkins
Affiliation:
J. A. Pye Research Centre, Walnut Tree Manor, Haughley Green, Stowmarket, Suffolk IP14 3RS
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Abstract

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1. Hypovitaminotic C guinea-pigs fed on a high-cholesterol diet for 5 weeks developed gallstones (810 mg cholesterol/g) whereas no concretements were observed in vitamin C-replete animals.

2. Scanning electron microscope studies of the three types of gallstone observed in the gallbladders of vitamin C-deficient animals showed them to be composed of randomly-arranged needle-shaped or laminated crystals of cholesterol.

3. The hepatic bile of gallstone-forming animals had a higher cholesterol concentration and lower bile acid content, the latter being principally due to a reduction in the chenodeoxycholic fraction, than the bile of vitamin C-replete animals.

4. No significant difference was observed between the volume of bile secreted by hypovitaminotic C and vitamin C-replete animals, but due to the qualitative changes in bile composition, gallstone formation was associated with an increased biliary secretion of cholesterol and a reduced secretion of bile acids.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 40 , Issue 2 , September 1978 , pp. 317 - 322
Copyright
Copyright © The Nutrition Society 1978

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