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Blood cholesterol and apolipoprotein B levels in relation to intakes of animal and plant proteins in US adults

Published online by Cambridge University Press:  09 March 2007

Ellen Smit ,
F. Javier Nieto  and
Carlos J. Crespo
Ellen Smit*
Affiliation:
Department of Epidemiology, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
F. Javier Nieto
Affiliation:
Department of Epidemiology, Johns Hopkins University, 615 N Wolfe Street, Baltimore, MD 21205, USA
Carlos J. Crespo
Affiliation:
Department of Health and Fitness, American University, Washington DC, USA
*
*Corresponding author: Dr Ellen Smit, fax +1 410 955 1383, email esmit@jhsph.edu
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Abstract

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Few studies have examined the association between specific sources of protein and blood lipids in a national sample of adults. We examined this relationship in a sample of adults 20 years and older who participated in phase 1 (1988–91) of the Third National Health and Nutrition Examination Survey, a representative sample of the United States non-institutionalized population. After excluding those participants who reported having been told they had high blood cholesterol concentrations, the final sample size was 6228. Mean intakes of different sources of proteins, as a percentage of total protein, were compared in quartiles of blood lipids. Intakes were adjusted for age, sex and race. Additional adjustments were made for other dietary variables, recall day, BMI, smoking, and income. We observed a lower percentage meat, fish and poultry (MFP) protein intake, including a lower percentage of beef and pork protein, among persons in the lowest quartile of serum total cholesterol and apolipoprotein B (ApoB) concentrations than among persons in the higher quartiles. The percentage of plant protein intake was higher in the lowest quartile than in the highest quartile of serum cholesterol. We also observed a higher percentage of fruit protein intake with lower serum cholesterol and ApoB concentrations. We conclude that in this cross-sectional sample, consumption of MFP proteins was consistently higher among persons with higher cholesterol concentrations while consumption of plant proteins was consistently higher among persons with lower cholesterol concentrations. Our findings support the importance of assessing intake of specific protein sources, especially in studies that address dietary intake in relation to blood lipids.

Keywords

Dietary proteinBlood cholesterolApolipoprotein BEpidemiology
Type
Research Article
Information
British Journal of Nutrition , Volume 82 , Issue 3 , September 1999 , pp. 193 - 201
Copyright
Copyright © The Nutrition Society 1999

References

Albers, JJ & Marcovina, SM (1989) Standardization of apolipoprotein B and A1 measurements. Clinical Chemistry 35, 1357–1361.CrossRefGoogle Scholar
Allain, CC, Poon, LS, Chan, CSG, Richmond, W & Fu, PC (1974) Enzymatic determinations of total serum cholesterol. Clinical Chemistry 20, 470–475.Google Scholar
Anderson, JW, Johnstone, BM & Cook-Newell, ME (1995) Meta-analysis of the effects of soy protein intake on serum lipids. New England Journal of Medicine 333, 276–282.CrossRefGoogle ScholarPubMed
Bachorik, PS, Lovejoy, KL, Carroll, MD, Johnson, CL, Albers, JJ & Marcovina, SM (1994) Measurement of apolipoproteins A-1 and B during the National Health and Nutrition Examination Survey (NHANES III). Clinical Chemistry 40, 1915–1920.CrossRefGoogle Scholar
Bakhit, RM, Klein, BP, Essex-Sorlie, D, Ham, JO, Erdman, JW & Potter, SM (1994) Intake of 25 g of soybean protein fiber alters plasma lipids in men with elevated cholesterol concentrations. Journal of Nutrition 124, 213–222.CrossRefGoogle ScholarPubMed
Beynen, AC & West, CE (1987) Cholesterol metabolism in swine fed diets containing either casein or soybean protein. Journal of the American Oil Chemists' Society 64, 1178–1182.CrossRefGoogle Scholar
Brick, JM, Broene, P, James, P & Severynse, J (1997) A User's Guide to WesVarPC. Rockville, MD: Westat Inc.Google Scholar
Campbell, TC & Chen, J (1994) Diet and chronic degenerative diseases: perspectives from China. American Journal of Clinical Nutrition 59, 1153S–1161S.Google Scholar
Campbell, TC, Chen, J, Liu, C, Li, J & Parpia, B (1990) Nonassociation of aflatoxin with primary liver cancer in a cross-sectional ecological survey in the People's Republic of China. Cancer Research 50, 6882–6893.Google Scholar
Carroll, KK (1978) Dietary protein in relation to plasma cholesterol levels and atherosclerosis. Nutrition Reviews 36, 1–5.CrossRefGoogle ScholarPubMed
Clayton, D & Hills, M (1993) Statistical Models in Epidemiology. New York, NY: Oxford University Press.Google Scholar
Conner, WE & Conner, SL (1972) The key role of nutritional factors in the prevention of coronary heart disease. Preventive Medicine 1, 49–83.Google Scholar
Friedewald, WT, Levy, RI & Fredrickson, DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clinical Chemistry 18, 499–502.CrossRefGoogle ScholarPubMed
Ignatowski, A (1908) Influence de la nourriture animale sur l'organisme des lapins (Influence of animal foods on the rabbit organism). Archives Medecine Experimentale Anatomie Pathologiques 20, 1–20.Google Scholar
Jacques, H, Laurin, D, Moorjani, S, Steinke, FH, Gagne, C, Brun, D & Lupien, PJ (1992) Influence of diets containing cow's milk or soy protein beverage on plasma lipids in children with familial hypercholesterolemia. Journal of the American College of Nutrition 11, Suppl., 69S–73S.CrossRefGoogle ScholarPubMed
Jenkins, DJ, Popvich, DG, Kendall, CW, Vidgen, E, Tariq, N, Ransom, TP, Wolever, TM, Vuksan, V, Mehling, CC, Boctor, DL, Bolognesi, C, Huang, J & Patten, R (1997) Effect of a diet high in vegetables, fruit, and nuts on serum lipids. Metabolism: Clinical and Experimental 45, 530–537.CrossRefGoogle Scholar
Karvetti, RL & Knuts, LR (1985) Validity of the 24-hour dietary recall. Journal of the American Dietetic Association 85, 1437–1442.CrossRefGoogle ScholarPubMed
Kritchevsky, D, Tepper, SA & Klurfeld, DM (1987) Dietary protein and atherosclerosis. Journal of the American Oil Chemists' Society 64, 1167–1171.CrossRefGoogle Scholar
McGee, D, Reed, D & Yano, K (1984) The results of logistic analyses when variables are highly correlated: an empirical example using diet and CHD incidence. Journal of Chronic Disease 39, 713–719.CrossRefGoogle Scholar
Marcovina, SM, Albers, JJ, Dati, F, Ledue, TB & Richie, RF (1991) International Federation of Clinical Chemistry standardization project for measurements of apolipoprotein a1 and b. Clinical Chemistry 37, 1676–1682.CrossRefGoogle ScholarPubMed
Meeker, DR & Kesten, HD (1940) Experimental atherosclerosis and high protein diets. Proceedings of the Society for Experimental Biology and Medicine 45, 543–545.Google Scholar
Meeker, DR & Kesten, HD (1941) Effect of high protein diets on experimental atherosclerosis of rabbits. Archives of Pathology 31, 147–162.Google Scholar
Melby, CL, Toohey, ML & Cebrick, J (1994) Blood pressure and blood lipids among vegetarian, semivegetarian, and nonvegetarian African Americans. American Journal of Clinical Nutrition 59, 103–109.CrossRefGoogle ScholarPubMed
Myers, GL, Cooper, GR, Winn, CL & Smith, SJ (1989) The Center for Disease Control–National Heart, Lung and Blood Institute Cholesterol Standardization Program. Clinical Laboratory Medicine 9, 105–135.CrossRefGoogle Scholar
National Center for Health Statistics (1994) Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988–1994. Vital and Health Statistics, series 1, no. 32. Hyattsville, MD: Public Health Service.Google Scholar
National Cholesterol Education Program (1993) Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). Bethesda, MD: National Heart, Lung and Blood Institute, National Institutes of Health.Google Scholar
Posner, BM, Cupples, LA, Miller, DR, Cobb, JL, Lutz, KJ & D'Agostino, RB (1993) Diet, menopause, and serum cholesterol levels in women: the Framingham Study. American Heart Journal 25, 483–489.CrossRefGoogle Scholar
Post, GB, Kemper, HC, Twisk, J & van Mechelen, W (1997) The association between dietary patterns and cardiovascular disease risk indicators in healthy youngsters: results covering fifteen years of longitudinal development. European Journal of Clinical Nutrition 51, 387–393.CrossRefGoogle ScholarPubMed
Potter, SM, Bahkit, RM, Essex-Sorlie, DL, Weingartner, KE, Chapman, KM, Nelson, RA, Prabhudesai, M, Savage, WD, Nelson, AI, Winter, LW & Erdman, JW (1993) Depression of plasma cholesterol in men by consumption of baked products containing soy protein. American Journal of Clinical Nutrition 58, 501–506.CrossRefGoogle Scholar
Reed, D, McGee, D, Yano, K & Hankin, J (1985) Diet, blood pressure and multicollinearity. Hypertension 7, 405–410.CrossRefGoogle ScholarPubMed
Schakel, SF, Warren, RA & Buzzard, IM (1989) Imputing nutrient values from manufacturers' data. In Proceedings of the 14th National Nutrient Databank Conference, pp. 155–158. Ithaca, NYCBORD Group Inc.Google Scholar
Sirtori, CR, Agradi, E, Conti, F, Mantero, O & Gatti, E (1977) Soybean-protein diet in the treatment of type-II hyperlipoproteinaemia. Lancet 1, 275–277.CrossRefGoogle ScholarPubMed
Smit, E, Nieto, FJ, Crespo, CJ & Mitchell, P (1999) Estimates of animal and plant protein intake in US adults: results from the Third National Health and Nutrition Examination Survey, 1988–1991. Journal of the American Dietetic Association 99, 813–820.CrossRefGoogle ScholarPubMed
Snowdon, DA (1988) Animal product consumption and mortality because of all causes combined, coronary heart disease, stroke, diabetes, and cancer in Seventh-day Adventists. American Journal of Clinical Nutrition 48, 739–749.CrossRefGoogle ScholarPubMed
Westrich, BJ, Buzzard, JM, Gatewood, LC & McGovern, PG (1994) Accuracy and efficiency of estimating nutrient values in commercial food products using mathematical optimization. Journal of Food Composition and Analysis 7, 223–239.CrossRefGoogle Scholar