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Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle size

Published online by Cambridge University Press:  09 March 2007

F. Guinotte ,
J. Gautron ,
Y. Nys  and
A. Soumarmon
F. Guinotte
Affiliation:
Station de Recherches Avicoles, INRA Centre de Tours, 37380 Nouzilly, France
J. Gautron
Affiliation:
Station de Recherches Avicoles, INRA Centre de Tours, 37380 Nouzilly, France
Y. Nys
Affiliation:
Station de Recherches Avicoles, INRA Centre de Tours, 37380 Nouzilly, France
A. Soumarmon
Affiliation:
Inserm Unité 10, Hôpital Bichat, 170 boulevard Ney, 75877 Paris Cedex 18, France
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Abstract

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In chicks, immature pullets and laying hens, the inhibition of gastric acid secretion by omeprazole, an H+,K+-transporting ATPase (EC 3.6.1.36) inhibitor, greatly increased proventricular and gizzard pH values. Consequently, gizzard soluble Ca concentration deceased and the insoluble Ca fraction increased. Inhibition of acid secretion increased duodenal pH values in immature pullets and laying hens but not in chicks. Duodenal soluble and ionic Ca concentrations were lowered by gastric acid inhibition in chicks and to a larger extent in immature pullets and laying hens. The use of Ca of coarse particle size increased the gizzard insoluble Ca fraction in chicks and pullets. However, it did not influence its soluble Ca fraction in chicks but tended to reinforce the negative effect of omeprazole on soluble Ca in the gizzard and duodenum of chicks and laying hens. Coarse particles of Ca led to an increase in gizzard and duodenal soluble Ca at the end of eggshell calcification in laying hens. An enhancement in the level of Ca in the diet from 10 to 36 g/kg increased gizzard soluble Ca and duodenal soluble and ionic Ca concentrations in immature and adult hens. Intestinal Ca retention and bone mineralization was unaffected by gastric acid inhibition in chicks but were largely diminished by the use of coarse particles of Ca. Gastric acid inhibition was associated in laying hens with decreased Ca retention to a small extent and with reduced eggshell quality. These observations confirm that gastric acid secretion is of importance for CaCO, solubilization but question its role as a prerequisite for intestinal Ca retention in chicks and even in hens fed on a high Ca diet.

Keywords

CalciumParticle sizeOmeprazoleGastric acid secretionChicken
Type
Research Article
Information
British Journal of Nutrition , Volume 73 , Issue 1 , January 1995 , pp. 125 - 139
Copyright
Copyright © The Nutrition Society 1995

References

REFERENCES

Akahori, F., Matsura, M. & Arai, K. (1971). Studies on the movement of the alimentary canal. VI. Physiological values in growing female chicks and quails. Bulletin of Azabu University of Veterinary Medicine 22, 25 Abstr.Google Scholar
Behar, J., Hitchings, M. & Smith, R. D. (1977). Calcium stimulation of gastrin and gastric acid secretion: effect of small doses of calcium carbonate. Gut 18, 442–448.Google Scholar
Bo-Linn, G. W., Davis, G. R., Buddrus, D. J., Morawski, S. G. & Santana, C. (1984). An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium. Journal of Clinical Investigation 73, 640–647.CrossRefGoogle ScholarPubMed
Gonalons, E. & Moretto, M. (1989). Intestinal motility and absorption of nutrients in the fowl. In Proceedings of the VIIIth European Poultry Symposium on Poultry Nutrition, pp. 13–27 [World's Poultry Science Association, editors]. Lloret del Mar, Spain: World's Poultry Science Association.Google Scholar
Grimstead, W. C., Pak, C. Y. K. & Krejs, G. J. (1984). Effects of 1,2S-dihydroxyvitamin D3 on calcium absorption in the colon of healthy humans. American Journal of Physiology 247, G189–G192.Google Scholar
Guinotte, F. (1992). Efficacité biologique de diverses sources de carbonate de calcium chez la poule pondeuse et le poulet de chair en croissance (Gallus domesticus). Rôle de la sécrétion acide du proventricule dans la solubilisation et l'utilisation digestive de ces sources (Biological efficiency of various calcium carbonate sources in hens and boilers (Gallus domesticus). Role of proventricular acid secretion in their solubility and intestinal retention). Doctoral thesis, Universitk de Paris VII.Google Scholar
Guinotte, F., Gautron, J., Soumarnon, A., Robert, J. C., Peranzi, G. & Nys, Y. (1993). Gastric acid secretion in the chicken: effect of histamine H2 antagonists and H+,K+ ATPase inhibitors on gastrointestinal pH and of sexual maturity, calcium carbonate level and particle size on proventricular H+,K+ ATPase activity. Comparative Biochemistry and Physiology 106A, 319–327.CrossRefGoogle Scholar
Guinotte, F. & Nys, Y. (1991). Effects of particle size and origin of calcium sources on eggshell quality and bone mineralization in egg laying hens. Poultry Science 70, 583–592.CrossRefGoogle Scholar
Guinotte, F., Nys, Y. & de Monredon, F. (1991). The effects of particle size and origin of calcium carbonate on performance and ossification characteristics in broiler chicks. Poultry Science 70, 1908–1920.CrossRefGoogle ScholarPubMed
INRA (1989). L'alimentation des anirnaux monogastriques: porc, lapin, volailles. Paris: Institut National de la Recherche Agronomique.Google Scholar
Itoh, H. (1967). Ca metabolism in laying hens. 5. Ca balance and mobilisation of Ca sources for eggshell formation. Japanese Journal of Zootechnical Science 38, 507–514.Google Scholar
Ivanovitch, P., Fellows, H. & Rich, C. (1967). The absorption of calcium carbonate. Annals of Intemationol Medicine 66, 917–923.CrossRefGoogle Scholar
Larsson, H., Carlsson, E., Junggren, U., Olbe, L., Sjostrand, S. V., Skanberg, I. & Sundell, G. (1983). Inhibition of gastric acid secretion by omeprazole in the dog and rat. Gastroenterology 85, 900–907.CrossRefGoogle ScholarPubMed
Long, J. F. (1967). Gastric secretion in unanesthetized chickens. American Journal of Physiology 212, 1303–1307.CrossRefGoogle ScholarPubMed
Low, A. G. (1990). Nutritional regulation of gastric secretion, digestion and emptying. Nutrition Research Reviews 3, 229–252.CrossRefGoogle ScholarPubMed
Mongin, P. (1976 a). Composition of crop and gizzard contents in the laying hen. British Poultry Science 17, 499–507.CrossRefGoogle ScholarPubMed
Mongin, P. (1976 b). Ionic constituents and osmolality of the small intestinal fluids of the laying hen. Brifish Poultry Science 17, 383–392.CrossRefGoogle ScholarPubMed
Nilas, L., Christiansen, C. & Christiansen, J. (1985).Regulation of vitamin D and calcium metabolism after gastrectomy. Gut 26, 252–257.Google Scholar
Nys, Y. & Cabrera-Saadoun, M. C. (1986). Daily changes in acid secretion, intestinal soluble calcium and study on carbonic anhydrase activity in pullets and laying hens laying shell-less or calcified eggs. VIIth European Poultry Conference, pp. 1037–1041 [Larbier, M., editor]. Paris: World's Poultry Science Association.Google Scholar
Pak, C. Y. C. & Avioly, L. V. (1988). Factors affecting absorbability of calcium from calcium salts and food. Calcified Tissue International 43, 55–60.CrossRefGoogle ScholarPubMed
Petith, M. M. & Schedl, H. P. (1976). Intestinal adaptation to dietary calcium restriction: in vivo caecal and colonic transport in the rat. Gastroenterology 71, 1039–1042.CrossRefGoogle ScholarPubMed
Rao, K. S. & Roland, D. A. Sr (1990). Retention pattern of various sized limestone particles in gizzard of commercial leghorn hens. Poultry Science 69, 185 Abstr.Google Scholar
Recker, R. R. (1985). Calcium absorption and achlohydria. New England Journal of Medicine 313, 70–73.CrossRefGoogle Scholar
Roche, M., Ruckebush, Y. & Achard, F. (1983). Effects of mash diet and pellets upon digestive motor functions in domestic hens and guinea hens. Canadian Journal of Animal Science 63, 663–669.CrossRefGoogle Scholar
Ruoff, H. J. & Sewing, K. F. (1971). The role of crop in the control of gastric acid secretion in chickens. Naunyn-Schmiedebergs Archiv fur Pharmakologie 271, 142–148.CrossRefGoogle Scholar
Sklan, D., Shachaf, B., Baron, J. & Hunvitz, S. (1978). Retrograde movement of digesta in the duodenum of the chick: extent, frequency and nutritional implications. Journal of Nutrition 108, 1485–1490.Google Scholar
Tuiiklanen, J. & Vaananen, H. K. (1986). Omeprazole, a specific inhibitor of H+,K+ ATPase, inhibits bone resorption in vitro. Calcijed Tissue International 38, 123–125.Google Scholar
van der Klis, J. D., Verstegen, M. W. A. & de Witt, W. (1991). Absorption of mineral and retention time of dry matter in the gastrointestinal tract of broilers. Poulrry Science 69, 2185–2194.CrossRefGoogle Scholar
Walt, R. P., Gomes, M.de F. A., Wood, E. C., Logan, L. H. & Pounder, R. E. (1983). Effect of daily omeprazole on 24 hours intragastric acidity. British Medical Journal 287, 12–14.CrossRefGoogle Scholar
Wyatt, C. L., Jensen, L. S. & Rowland, G. N. (1990). Effects of cimetidine on eggshell quality and plasma 25-hydroxycholecalciferol in laying hens. Poultry Science 69, 1892–1899.CrossRefGoogle ScholarPubMed