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The case for strategic international alliances to harness nutritional genomics for public and personal health†

Published online by Cambridge University Press:  08 March 2007

Jim Kaput ,
Jose M. Ordovas ,
Lynnette Ferguson ,
Ben van Ommen ,
Raymond L. Rodriguez ,
Lindsay Allen ,
Bruce N. Ames ,
Kevin Dawson ,
Bruce German  and
Ronald Krauss
...Show all authors
Jim Kaput*
Affiliation:
Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Jose M. Ordovas
Affiliation:
Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Lynnette Ferguson
Affiliation:
National Centre for Research Excellence in Nutrigenomics, University of Auckland, Auckland, New Zealand
Ben van Ommen
Affiliation:
NuGO – TNO Quality of Life, Zeist, The Netherlands
Raymond L. Rodriguez
Affiliation:
Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA
Lindsay Allen
Affiliation:
USDA-ARS Western Human Nutrition Research Center at the University of California, Davis, CA 95616, USA
Bruce N. Ames
Affiliation:
Children's Hospital of Oakland Research Institute, Oakland, CA 94609, USA
Kevin Dawson
Affiliation:
Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA
Bruce German
Affiliation:
Department of Food Science and Technology, University of California, Davis, CA 95616, USA
Ronald Krauss
Affiliation:
Children's Hospital of Oakland Research Institute, Oakland, CA 94609, USA
Wasyl Malyj
Affiliation:
Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA
Michael C. Archer
Affiliation:
University of Alabama Center for Nutrient–Gene Interactions, University of Alabama, Birmingham, Alabama 35294-0005, USA
Stephen Barnes
Affiliation:
Laboratory of Nutrigenomic Medicine, Department of Surgery, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Amelia Bartholomew
Affiliation:
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Ruth Birk
Affiliation:
Department of Biotechnology Engineering, Ben-Gurion University at the Negev, Beer-Sheeva 84105, Israel
Peter van Bladeren
Affiliation:
Nestlé Research Center, Lausanne, Switzerland
Kent J. Bradford
Affiliation:
Seed Biotechnology Center, Plant Reproductive Biology, University of California, Davis, CA 95616, USA
Kenneth H. Brown
Affiliation:
Program in International Nutrition, Department of Nutrition University of California, Davis, CA 95616, USA
Rosane Caetano
Affiliation:
Department of Health Sciences, Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Rua São Francisco, 501 - Bairro São Geraldo Ijuí - RS - Brasil
David Castle
Affiliation:
Department of Philosophy, University of Guelph, Ontario, Canada
Ruth Chadwick
Affiliation:
ESRC Centre for the Economic and Social Aspects of Genomics (CESAGen), Lancaster University, Lancaster LA1 4YG, UK
Stephen Clarke
Affiliation:
McNeil Nutritionals, New Brunswick, NJ, USA
Karine Clément
Affiliation:
INSERM ‘Avenir’ Nutrition dpt Hôtel-Dieu, EA3502, UMPC Paris 6, France
Craig A. Cooney
Affiliation:
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Dolores Corella
Affiliation:
Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, Valencia, Spain
Ivana Beatrice Manica da Cruz
Affiliation:
Department of Health Sciences, Universidade Regional do Noroeste do Estado do Rio Grande do Sul, Rua São Francisco, 501 - Bairro São Geraldo Ijuí - RS – Brasil
Hannelore Daniel
Affiliation:
NuGO – Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, 85350 Freising-Weihenstephan, Germany
Troy Duster
Affiliation:
Department of Sociology, New York University, NY, NY 10003 and Institute for the Study of Social Change, University of California, Berkeley, CA 94720-5670, USA
Sven O. E. Ebbesson
Affiliation:
Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Ruan Elliott
Affiliation:
Institute of Food Research, Norwich NR4 7UA, UK
Susan Fairweather-Tait
Affiliation:
Institute of Food Research, Norwich NR4 7UA, UK
Jim Felton
Affiliation:
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
Michael Fenech
Affiliation:
CSIRO Health Sciences and Nutrition, Adelaide SA, 5000, Australia
John W. Finley
Affiliation:
AM Todd, Montgomeryville, PA 18936, USA
Nancy Fogg-Johnson
Affiliation:
Life Science Alliance, Villanova, PA 19085, USA
Rosalynn Gill-Garrison
Affiliation:
Sciona, Inc., Boulder, CO 80302, USA
Michael J. Gibney
Affiliation:
NuGO – Nutrition Unit Department of Clinical Medicine, Trinity College, Dublin, Republic of Ireland
Peter J. Gillies
Affiliation:
Human Health Sciences, DuPont Nutrition & Health, Newark, DE, Centre of Excellence in Nutrigenomics, Penn State University, University Park, PA, USA
Jan-Ake Gustafsson
Affiliation:
Department of Medical Nutrition, Center for Biotechnology, Karolinska Instututet, Novum, SE-141 86, Huddinge, Sweden
John L. Hartman IV
Affiliation:
Department of Genetics, University of Alabama, Birmingham, Alabama 35294-0024, USA
Lin He
Affiliation:
Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences, Shanghai 200031, China
Jae-Kwan Hwang
Affiliation:
Department of Biotechnology, Yonsei University, Seoul, Korea
Jean-Philippe Jais
Affiliation:
Department of Biostatistics and Bioinformatics, Hôpital Necker Enfants Malades, Université Paris 5, Paris, France
Yangsoo Jang
Affiliation:
Department of Internal Medicine, Yonsei University, Seoul, Korea
Hans Joost
Affiliation:
NuGO – German Institute for Human Nutrition, Potsdam Rehbrücke, Germany
Claudine Junien
Affiliation:
Department of Genetics, Hôpital Necker Enfants Malades, Clinique Maurice Larny, Paris, 75743, France
Mitchell Kanter
Affiliation:
Cargill, Inc., Wayzata, MN 55305, USA
Warren A. Kibbe
Affiliation:
Center of Genetic Medicine, Center for Functional Genomics, Robert Lurie Comprehensive Cancer Center, NorthWestern University Medical School, Chicago, IL 60611, USA
Berthold Koletzko
Affiliation:
Dr von Hauner Children's Hospital, University of Munich, Germany
Bruce R. Korf
Affiliation:
Department of Genetics, University of Alabama, Birmingham, Alabama 35294-0024, USA
Kenneth Kornman
Affiliation:
Interleukin Genetics, Inc., Waltham, MA 02452, USA
David W. Krempin
Affiliation:
Nutrilite Division of Access Business Group, LLC, Buena Park, CA 90622, USA
Dominique Langin
Affiliation:
Obesity Research Unit, Institut Louis Bugnard, French Institute of Health and Medical Research (Inserm), Toulouse University Hospitals, Paul Sabatier University, 31059 Toulouse, France
Denis R. Lauren
Affiliation:
National Centre for Research Excellence in Nutrigenomics, University of Auckland, Auckland, New Zealand HortResearch, Ltd, Hamilton, New Zealand
Jong Ho Lee
Affiliation:
Department of Food and Nutrition, Yonsei University, Seoul, Korea
Gilbert A. Leveille
Affiliation:
Food Systems Design, Denville, NJ 07834, USA
Su-Ju Lin
Affiliation:
Department of Microbiology, Division of Biological Sciences, University of California, Davis, CA 95616, USA
John Mathers
Affiliation:
NuGO – Human Nutrition Research Centre, Newcastle University, UK
Michael Mayne
Affiliation:
Institute for Nutrisciences and Health, National Research Council of Canada, Charlottetown, Prince Edward Island, Canada C1A 5T1
Warren McNabb
Affiliation:
National Centre for Research Excellence in Nutrigenomics, University of Auckland, Auckland, New Zealand AgResearch Limited, Grasslands Research Centre, Palmerston North, New Zealand
John A. Milner
Affiliation:
Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Peter Morgan
Affiliation:
Rowett Research, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
Michael Muller
Affiliation:
NuGO – Dutch Innovative Cluster Nutrigenomics, Wageningen Centre for Food Science and Nutrition, Metabolism and Genomics, Wageningen University, Wageningen, The Netherlands
Yuri Nikolsky
Affiliation:
GeneGo, Inc., St Joseph, MI 49085, USA
Frans van der Ouderaa
Affiliation:
Unilever Corporate Research, Colworth House, Sharnbrook, Beds MK44 1PY, UK
Taesun Park
Affiliation:
Department of Food and Nutrition, Yonsei University, Seoul, Korea
Norma Pensel
Affiliation:
Instituto Tecnología de Alimentos, Instituto Nacional de Tecnología Agropecuaria (INTA), Buenos Aires, Argentina
Francisco Perez-Jimenez
Affiliation:
Hospital Universitario Reina Sofia, Unidad Lipidos & Arteriosclerosis, Cordoba, Spain
Kaisa Poutanen
Affiliation:
Food and Health Research Centre, University of Kuopio, Mediteknia, Box 1627, 70211 KUOPIO, Finland
Matthew Roberts
Affiliation:
Purina/Nestle, St Louis, MO, USA
Wim H.M. Saris
Affiliation:
NuGO – Nutrition and Toxicology Research Institute NUTRIM, University of Maastricht, The Netherlands
Gertrud Schuster
Affiliation:
Department of Nutrition, University of California, Davis, CA 95616-8669, USA
Andrew N. Shelling
Affiliation:
National Centre for Research Excellence in Nutrigenomics, University of Auckland, Auckland, New Zealand Faculty of Medical & Health Sciences, The University of Auckland, Auckland, New Zealand
Artemis P. Simopoulos
Affiliation:
The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
Sue Southon
Affiliation:
NuGO – Institute of Food Research, Norwich NR4 7UA, UK
E. Shyong Tai
Affiliation:
Department of Endocrinology, Singapore General Hospital, Singapore 169608, Republic of Singapore
Bradford Towne
Affiliation:
Department of Community Health, Wright State University School of Medicine, Dayton, OH 45401-0927, USA
Paul Trayhurn
Affiliation:
Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Ricardo Uauy
Affiliation:
Public Health Nutrition, London School of Hygiene and Tropical Medicine, London, and Instituto de Nutricion y Tecnologia de los Alimentos (INTA), University of Chile, Santiago, Chile
Willard J. Visek
Affiliation:
Department of Internal Medicine, University of Illinois College of Medicine, Urbana, IL 61821, USA
Craig Warden
Affiliation:
Neurobiology, Physiology, and Behavior Section of Division of Biological Sciences, University of California, Davis, CA 95616, USA
Rick Weiss
Affiliation:
Viocare Technologies, Inc., Princeton, NJ 08542, USA
John Wiencke
Affiliation:
Department of Epidemiology and Biostatistics and Division of Neuroepidemiology, University of California, San Francisco, CA 94143-0112, USA
Jack Winkler
Affiliation:
Food and Health Research, London N1 7AB, UK
George L. Wolff
Affiliation:
National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA
Xi Zhao-Wilson
Affiliation:
BioMarker Pharmaceuticals, Inc., Campbell, CA 95008, USA
Jean-Daniel Zucker
Affiliation:
LIM&BIO, EPML-CNRS IAPuces, Universite Paris XIII, 74 rue Marcel Cachin 93017 Bobigny Cedex, France
*
Corresponding author: Dr Jim Kaput, fax +1 312 829 3357 email jkaput@uic.edu
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Abstract

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Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.

Keywords

Strategic international alliancesNutrigenomicsGene–nutrient interactionsHealth diaparities
Type
Horizons in Nutritional Science
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 623 - 632
Copyright
Copyright © The Nutrition Society 2005

Footnotes

†

This document is an outgrowth of the Bruce Ames International Symposium on Nutritional Genomics held at the University of California, Davis, CA on 22–24 October 2004. The statements and opinions expressed are those of symposium participants and others who are contributing to nutrigenomics or related research fields. The present paper is intended to stimulate discussion about the interplay of nutrition and genetics and the potential of nutrigenomics to improve global health.

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