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Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing rats

Published online by Cambridge University Press:  09 March 2007

Christopher J. Laing  and
David R. Fraser
Christopher J. Laing*
Affiliation:
Faculty of Veterinary Science, University of Sydney 2006, Australia
David R. Fraser
Affiliation:
Faculty of Veterinary Science, University of Sydney 2006, Australia
*
*Corresponding author:Dr Christopher J. Laing, present address, Department of Genetics, 760 Clinical Research Building, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104-6144, USA, fax +1 215 573 5809, email claing@mail.med.upenn.edu
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Abstract

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The work presented here examines the possible effects of nutritional deficiencies on the characteristics of the plasma transport protein for vitamin D and its metabolites (vitamin D binding protein, DBP) in the growing rat. Deficiencies in both dietary protein intake and dietary energy intake may decrease the concentration of DBP in the circulation, although plasma DBP was not affected by dietary Ca deficiency. None of the dietary factors examined appears to influence the affinity of DBP for its major ligand, 25-hydroxycholecalciferol (25(OH)D3). Protein-deficient rats seemed to have difficulty in maintaining adequate concentrations of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) in the circulation. The sensitivity of DBP to dietary protein and energy intake may constitute a novel mechanism that may help to explain the observed associations between malnutrition and the development of metabolic bone disease, through alterations to the cellular availability of vitamin D ligands to DBP.

Keywords

Plasma vitamin D binding proteinCholecalciferolMalnutrition
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue 2 , August 2002 , pp. 133 - 139
Copyright
Copyright © The Nutrition Society 2002

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