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A comparison of the influence on plasma lipids and platelet function of supplements of ω3 and ω6 polyunsaturated fatty acids

Published online by Cambridge University Press:  24 July 2007

T. A. B. Sanders  and
Michele C. Hochland
T. A. B. Sanders
Affiliation:
Department of Nutrition, Queen Elizabeth College, University of London, Campden Hill Road, London W8 7AH
Michele C. Hochland
Affiliation:
Department of Nutrition, Queen Elizabeth College, University of London, Campden Hill Road, London W8 7AH
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Abstract

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1. A randomized double-blind crossover trial was carried out to compare the influence on plasma lipid concentrations, platelet thromboxane B2 production and platelet aggregation induced by ADP, collagen and U46619 (a prostaglandin endoperoxide analogue), of a daily 10 g supplement of a fish-oil concentrate (MaxEPA), which provided (g): 1·7 20:5ω3, 0·3 22:5ω3 and 1·2 22:6ω3, taken for 2 weeks by ten healthy subjects, with one of vegetable oil providing 3·4 18:2ω6.

2. A lower response to platelet aggregation induced by 0·5 μg collagen/ml but not by other aggregating agents was observed following both types of supplement. Platelet thromboxane B2 production induced by collagen also tended to be lower following the supplements.

3. Plasma total cholesterol concentrations were unaffected by the supplements. The MaxEPA but not the vegetable-oil supplement lowered the concentration of plasma triglycerides and increased that of high-density-lipoprotein-cholesterol.

Type
Research Article
Information
British Journal of Nutrition , Volume 50 , Issue 3 , November 1983 , pp. 521 - 529
Copyright
Copyright © The Nutrition Society 1983

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