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Dietary cholesterol lowers the activity of butyrylcholinesterase (EC 3.1.1.8), but elevates that of esterase-1 (EC 3.1.1.1) in plasma of rats

Published online by Cambridge University Press:  02 April 2007

H. A. Van Lith  and
A. C. Beynen
H. A. Van Lith
Affiliation:
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, NL-3508 TD Utrecht, The Netherlands
A. C. Beynen
Affiliation:
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.166, NL-3508 TD Utrecht, The Netherlands
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Abstract

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The question addressed is whether an increased intake of cholesterol affects esterase-1 (EC 3.1.1.1; ES-1) and butyrylcholinesterase (EC 3.1.1.8) activity in plasma. Rats were fed on a purified diet either without or with cholesterol (10 g/kg) added at the expense of the carbohydrate source. Dietary cholesterol significantly decreased plasma butyrylcholinesterase activity, but raised plasma ES-1 activity. Evidence is discussed, suggesting that plasma butyrylcholinesterase is involved in plasma cholesterol metabolism, whereas esterase-1 is involved in intestinal cholesterol absorption.

Keywords

ButyrylcholinesteraseEsterase-1 (ES- 1)Dietary cholesterolPlasmaLiverRat
Type
Lipid Metabolism
Information
British Journal of Nutrition , Volume 70 , Issue 3 , November 1993 , pp. 721 - 726
Copyright
Copyright © The Nutrition Society 1993

References

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