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Dietary effects on pancreatic lesions induced by excess arginine in rats

Published online by Cambridge University Press:  09 March 2007

Shigeyuki Takama  and
Yasuo Kishino
Shigeyuki Takama
Affiliation:
Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima 770, Japan
Yasuo Kishino
Affiliation:
Department of Nutrition, School of Medicine, The University of Tokushima, Tokushima 770, Japan
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Abstract

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1. The effect of nutrition on the incidence of pancreatic damage was studied. Injection of excess arginine was found to cause more massive necrosis of the acinar cells after 24 h in malnourished rats (those given 50 g casein/kg diet) than in well-nourished rats (those given 200 g casein/kg diet).

2. Ultrastructural examination showed that whorl formation of the endoplasmic reticulum, decreases in the number of zymogen granules and formation of vacuoles in the cytoplasm were more marked in rats given 50 g casein/kg diet. Degradation of zymogen granules within vacuoles in the damaged cells was frequently observed in rats given 200 g casein/kg diet.

3. Necrosis of adipose tissue was associated with pancreatic damage more frequently in rats given 200 g casein/kg diet; rats with large amounts of zymogen granules in the acinar cells showed particularly severe necrosis of adipose tissue. Rats given 50 g casein/kg diet did not show necrosis of adipose tissue.

4. These results indicate that in the malnourished state there were more marked arginine lesions of the pancreas in which to study cellular and histologic changes than in the well-nourished state and that the occurrence of necrosis of adipose tissue may be related to a high content of zymogen granules in the acinar cells before pancreatic damage.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 1 , July 1985 , pp. 37 - 42
Copyright
Copyright © The Nutrition Society 1985

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