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Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects

Published online by Cambridge University Press:  08 March 2007

Timur Anlasik ,
Helmut Sies ,
Helen R. Griffiths ,
Patrizia Mecocci ,
Wilhelm Stahl  and
M. Cristina Polidori
Timur Anlasik
Affiliation:
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, D-40225 Düsseldorf, Germany
Helmut Sies
Affiliation:
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, D-40225 Düsseldorf, Germany
Helen R. Griffiths
Affiliation:
Life and Health Sciences, Aston University, Birmingham, UK
Patrizia Mecocci
Affiliation:
Institute of Geriatrics and Gerontology, Perugia University Hospital, Perugia, Italy
Wilhelm Stahl
Affiliation:
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, D-40225 Düsseldorf, Germany
M. Cristina Polidori*
Affiliation:
Institute of Biochemistry and Molecular Biology I, Heinrich-Heine University, D-40225 Düsseldorf, Germany
*
*Corresponding author: Dr M. Cristina Polidori, fax +49 211 81 15 980, email polidori@uni-duesseldorf.de
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Abstract

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Previous studies indicate that regular consumption of a diet rich in fruits and vegetables is associated with a lower risk for age-related diseases. The aim of the present study was to evaluate whether the often-reported age-related decrease of plasma antioxidants in man depends on differences in dietary intake or on other age- and gender-related factors. In this observational case-control study, thirty-nine community-dwelling healthy subjects aged 65 years and older consuming high intakes of fruits and vegetables daily (HI) and forty-eight healthy subjects aged 65 and older consuming low intakes of fruit and vegetables daily (LI) were enrolled. Plasma levels of retinol, tocopherols, carotenoids and malondialdehyde (MDA) as well as content of protein carbonyls in Ig G were measured. Plasma levels of retinol, tocopherols and carotenoids were significantly higher in group HI than in group LI subjects independent of age and gender. MDA levels were inversely correlated with vitamin A and α-carotene. Protein carbonyls were inversely correlated with γ-tocopherol. In the elderly, a higher daily intake of fruits and vegetables is associated with an improved antioxidant status in comparison to subjects consuming diets poor in fruits and vegetables. Modification of nutritional habits among other lifestyle changes should be encouraged to lower prevalence of disease risk factors in later life.

Keywords

AgeingAntioxidantsNutritionPrevention
Type
Sort communication
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 639 - 642
Copyright
Copyright © The Nutrition Society 2005

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