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Dietary linoleic acid at high and reduced dietary fat level decreases the faecal excretion of vitamin E in young rats

Published online by Cambridge University Press:  09 March 2007

Lilian B. M. Tuburg ,
Edward Haddeman ,
Gerard A. A. Kivits ,
Jan A. Weststrate  and
Elizabeth J. Brink
Lilian B. M. Tuburg
Affiliation:
Unilever Research Laboratory, PO Box 114, 3130 AC Vlaardingen, The Netherlands
Edward Haddeman
Affiliation:
Unilever Research Laboratory, PO Box 114, 3130 AC Vlaardingen, The Netherlands
Gerard A. A. Kivits
Affiliation:
Unilever Research Laboratory, PO Box 114, 3130 AC Vlaardingen, The Netherlands
Jan A. Weststrate
Affiliation:
Unilever Research Laboratory, PO Box 114, 3130 AC Vlaardingen, The Netherlands
Elizabeth J. Brink
Affiliation:
Unilever Research Laboratory, PO Box 114, 3130 AC Vlaardingen, The Netherlands
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Abstract

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Vitamin E is the major lipid-soluble antioxidant in human subjects and is crucial in protecting polyunsaturated fatty acids (PUFA) against lipid peroxidation. Dietary PUFA have been suggested to inhibit the absorption of vitamin E. The present study in young male rats was designed to investigate the effect of increasing concentrations of dietary linoleic acid on the faecal excretion of vitamin E. The rats were fed on semi-synthetic diets containing two concentrations of fat (59 g/kg diet, 15 energy % (en%) or 131 g/kg, 30 en%) for 3 weeks. Triacylglycerol rich in linoleic acid was added at the expense of triacylglycerol rich in saturated fatty acids to obtain dietary concentrations of 13,39 or 66 g linoleic acid/kg diet for the high-fat diet (131 g fat/kg) and 12, 24 or 36 g linoleic acid/kg diet for the reduced-fat diet (59 g fat/kg). The results from the present study demonstrate that the faecal excretion of vitamin E was significantly lower in rats fed on diets with high levels of linoleic acid compared with rats fed on lower levels of linoleic acid irrespective of the dietary fat content. The concentration of vitamin E in liver and plasma was significantly lower in animals fed on the highest concentration of linoleic acid compared with those fed on the lowest level. Results from the present study also demonstrate that at the same concentration of linoleic acid, the faecal excretion of vitamin E in rats fed on reduced-fat diets was significantly lower than in rats fed on high-fat diets. Our findings indicate that the apparent absorption of vitamin E is not inhibited by dietary PUFA. Results from the present study also demonstrate that a reduction of dietary fat content from 30 en% to 15 en% does not lower the apparent absorption of vitamin E

Keywords

Linoleic acidVitamin ERats
Type
General Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 2 , February 1997 , pp. 327 - 336
Copyright
Copyright © The Nutrition Society 1997

References

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