Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-10T17:29:09.810Z Has data issue: false hasContentIssue false
  • English
  • Français

Dietary phosphorus restriction to half the minimum required amount slightly reduces weight gain and length of tibia, but sustains femur mineralization and prevents nephrocalcinosis in female kittens

Published online by Cambridge University Press:  09 March 2007

F. J. H. Pastoor ,
R. Otitz ,
A. TH. Van Tklooster  and
A. C. Beynen
F. J. H. Pastoor
Affiliation:
Department of Laboratory Animal Science, Utrecht University, Utrecht, The Netherlands
R. Otitz
Affiliation:
Department of Laboratory Animal Science, Utrecht University, Utrecht, The Netherlands
A. TH. Van Tklooster
Affiliation:
Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
A. C. Beynen
Affiliation:
Department of Laboratory Animal Science, Utrecht University, Utrecht, The Netherlands Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The effects of dietary P restriction to half the recommended minimum level on growth, bone and renal mineralization and urinary composition were studied in female kittens. In two separate experiments, 8-week-old weanling kittens were fed on purified diets containing either 4·6 or 9·2 mmol P/MJ (2·8 or 5·6 g P/kg diet). In the second experiment there was an additional low-P diet in which the Ca concentration was reduced from 9·5 to 4·8 mmol/MJ (7·5 v. 3.8 g Ca/kg diet). P restriction slightly but systematically reduced weight gain (to a maximum of 16%) and growth of the tibia (by 1–4%); the former effect was statistically significant (P < 0·05) between the ages of 15 and 20 weeks in Expt 1 only, and the latter did not reach statistical significance at any time point (P g 0·13). No adverse effect of P restriction was found on mineralization of femur at the age of 39 weeks. Kidney Ca concentrations were significantly lowered (Expt 1, 6 v. 20/μmol/g dry weight, P < 0-001; Expt 2, 7 v. 16/μmol/g dry weight, P < 0-01) in cats fed on the low-P diets, this effect not being affected by the dietary Ca:P ratio. Urinary P concentration was significantly depressed (by 50–96%) after feeding the low-P diets (P < 0-001). P intake did not influence P, Ca and Mg retention during the period of 15 to 39 weeks of age.

Keywords

PhosphorusMineral excretionBoneNephrocalcinosisCat
Type
Mineral metabolism in companion animals
Information
British Journal of Nutrition , Volume 74 , Issue 1 , July 1995 , pp. 85 - 100
Copyright
Copyright © The Nutrition Society 1995

References

Brink, E. J., Beynen, A. C, Dekker, P., R Van Beresteijn, E. C. H. & Van der Meer, R. (1992). Interaction of calcium and phosphate decreases ileal magnesium solubility and apparent magnesium absorption in rats. Journal of Nutrition 122, 580–586.Google Scholar
Buffington, C. A., Cook, N. E., Rogers, Q. R. & Morris, J. G. (1989). The role of diet in feline struvite urolithiasis syndrome. In Nutrition of the Dog and Cat, pp. 357–380 [Burger, I. H. and Rivers, J. P. W., editors]. Cambridge: Cambridge University Press.Google Scholar
Carey, C. J. & Morris, J. G. (1977). Biotin deficiency in the cat and the effect of hepatic propionyl CoA carboxylase. Journal of Nutrition 107, 330–334.CrossRefGoogle Scholar
Cowgill, L. D. (1983). Diseases of the kidney. In Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat, pp. 1793–1879 [Ettinger, S. J. editor]. Philadelphia, PA: W. B. Saunders Company.Google Scholar
Finco, D. R. (1983). The role of phosphorus restriction in the management of chronic renal failure in the dog and cat. In Proceedings of the Kal Kan Symposium for Treatment of Small Animal Diseases, pp. 131–133 [Van Marthens, E. editor]. Vernon, CA: Kal Kan Foods, Inc.Google Scholar
Graser, D. H., Hama.r, D. W. & Lewis, L. D. (1981). The consistency of dietary minerals in commercial cat food and their relationship to feline urolithiasis. Feline Practice 11(2), 41–47.Google Scholar
Kootstra, Y., Ritskes-Hoitinga, J., Lemmens, A. G. & Beynen, A. C. (1991). Diet-induced calciuria and nephrocalcinosis in female rats. International Journal for Vitamin and Nutrition Research 61, 100–101.Google ScholarPubMed
Lawler, D. F., Sjolin, D. W. & Collins, J. E. (1985). Incidence rates of feline lower urinary tract disease in the United States. Feline Practice 15(5), 13–16.Google Scholar
Lewis, L. D., Chow, F. H. C, Taton, G. F. & Hamar, D. W. (1978). Effects of various dietary mineral concentrations on occurrence of feline urolithiasis. Journal of the American Veterinary Medical Association 172, 559–563.Google Scholar
Lewis, L. D., Morris, M. L. & Hand, M. S. (1987). Small Animal Clinical Nutrition III, pp. 8–1–8–51. Topeka, Kansas: Mark Morris Associates.Google Scholar
Lucke, V. M. & Hunt, A. C. (1967). Renal calcification in the domestic cat. Pathologia Veterinaria 4, 120–136.CrossRefGoogle Scholar
Mallory, F. B. (1961). Pathological Technique, p. 144. New York, NY: Hafner Publishing.Google Scholar
National Research Council (1978). Nutrient Requirements of Laboratory Animals. Washington DC: National Academy of Sciences.Google Scholar
National Research Council (1986). Nutrient Requirements of Cats. Washington DC: National Academy Press. Pariza, M. W. (1987). Dietary fat, calorie restriction, ad libitum feeding, and cancer risk. Nutrition Reviews 45, 1–7.Google Scholar
Pastoor, F. J. H. (1993). Interactions of dietary minerals in the cat. PhD Thesis, Utrecht University, The Netherlands.Google Scholar
Pastoor, F. J. H., Van Herck, H., Van 't Klooster, A. Th. & Beynen, A. C. (1991 a). Biotin deficiency in cats as induced by feeding a purified diet containing egg white. Journal of Nutrition 121, S73–S74.CrossRefGoogle ScholarPubMed
Pastoor, F. J. H., Van 't Klooster, A. Th. & Beynen, A. C. (1990). An alternative method for the quantitative collection of faeces and urine of cats as validated by the determination of mineral balance. Zeitschrift fur Versuchstierkunde 33, 259–263.Google Scholar
Pastoor, F. J. H., Van 't Klooster, A. Th., Lankhorst, A., Mathot, J. N. J. J. & Beynen, A. C. (1991 A). An alternative method for the collection of urine and feces and its application in measuring urinary mineral excretion in cats fed diets containing various amounts of phosphorus. Journal of Nutrition 121, S85–S86.Google Scholar
Pastoor, F. J. H., Van't Klooster, A. Th., Mathot, J. N. J. J. & Beynen, A. C. (1994 a). Increasing calcium intakes lower urinary concentrations of phosphorus and magnesium in adult ovariectomized cats. Journal of Nutrition 124, 299–304.CrossRefGoogle ScholarPubMed
Pastoor, F. J. H., Opitz, R., Van 't Klooster, A. Th. & Beynen, A. C. (1946). Dietary calcium chloride vs. calcium carbonate reduces urinary pH and phosphorus concentration, improves bone mineralization and depresses kidney calcium level in cats. Journal of Nutrition 124, 2212–2222.CrossRefGoogle Scholar
Ritskes-Hoitinga, J., Lemmens, A. G., Danse, L. H. J. C. & Beynen, A. C. (1989). Phosphorus-induced nephrocalcinosis and kidney function in female rats. Journal of Nutrition 119, 1423–1431.CrossRefGoogle ScholarPubMed
Ross, L. A., Finco, D. R. & Crowell, W. A. (1982). Effect of dietary phosphorus restriction on the kidneys of cats with reduced renal mass. American Journal of Veterinary Research 43, 1023–1026.Google ScholarPubMed
Ross, M. H., Lustbader, E. & Bras, G. (1976). Dietary practices and growth responses as predictors of longevity. Nature 262, 548–553.CrossRefGoogle ScholarPubMed
Sauer, L. S., Hamar, D. & Lewis, L. D. (1985). Effect of dietary mineral composition on urinary mineral concentration and excretion by the cat. Feline Practice 15(4), 10–15.Google Scholar
Schaafsma, G. & Visser, R. (1980). Nutritional interrelationships between calcium, phosphorus and lactose in rats. Journal of Nutrition 110, 1101–1111.CrossRefGoogle ScholarPubMed
Schoenmakers, A. C. M., Ritskes-Hoitinga, J., Lemmens, A. G. & Beynen, A. C. (1989). The influence of dietary phosphorus restriction on calcium and phosphorus metabolism in rats. International Journal for Vitamin and Nutrition Research 59, 200–206.Google ScholarPubMed
Scott, P. P. (1965). Minerals and vitamins in feline nutrition. In Canine and Feline Nutrition Requirements, pp. 75–89 [Graham-Jones, O. editor]. London: Pergamon Press.Google Scholar
SPSS, Inc. (1988 a). SPSS/PC+ Advanced Statistics V2.0. Chicago, IL: SPSS Inc.Google Scholar
SPSS, Inc. (1988 b). SPSS/PC + TM V2.0. Base Manual. Chicago, IL: SPSS Inc.Google Scholar
Steel, R. G. D. & Torrie, J. H. (1981). Principles and Procedures of Statistics. A Biochemical Approach, 2nd ed. Tokyo: McGraw-Hill International Book Co.Google Scholar