Hostname: page-component-745bb68f8f-s22k5 Total loading time: 0 Render date: 2025-01-27T10:44:07.897Z Has data issue: false hasContentIssue false
  • English
  • Français

Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat

Published online by Cambridge University Press:  09 March 2007

J. Leyton ,
P. J. Drury  and
M. A. Crawford
J. Leyton
Affiliation:
Nutritional Biochemistry Unit, The Institute of Zoology, Regent's Park, London NWl 4RY
P. J. Drury
Affiliation:
Nutritional Biochemistry Unit, The Institute of Zoology, Regent's Park, London NWl 4RY
M. A. Crawford
Affiliation:
Nutritional Biochemistry Unit, The Institute of Zoology, Regent's Park, London NWl 4RY
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The oxidation rates of lauric, myristic, palmitic, stearic, oleic, α-linolenic, linoleic, γ-linolenic, dihomo- γ-linolenic and arachidonic acids were studied by use of a radioisotope tracer technique in weanling rats at rest in a metabolism chamber over 24 h.

2. Of the saturated fatty acids, lauric acid (12:O) was the most efficient energy substrate: the longer the chain length of the saturated fatty acids, the slower the rate of oxidation.

3. Oleic acid (18:1) was oxidized at a remarkably fast rate, similar to that of lauric acid.

4. Of the ω6 essential fatty acids studied, linoleic acid (18:2ω6) was oxidized at a faster rate than any of its metabolites, with arachidonic acid (20:4ω6) being oxidized at the slowest rate.

5. The rate of oxidation of γ-linolenic acid (18:3ω3) was almost as fast as that of lauric and oleic acids.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 57 , Issue 3 , May 1987 , pp. 383 - 393
Copyright
Copyright © The Nutrition Society 1987

References

REFERENCES

Bandyopadhyay, G. K., Dutta, J. & Ghosh, S. (1982). Lipids 17, 733–740.CrossRefGoogle Scholar
Bloom, B., Chaikoff, I. L. & Reinhardt, W. O. (1951). American Journal of Physiology 166, 451–455.CrossRefGoogle Scholar
Brenner, R. R. (1981). Progress in Lipid Research 20, 41–47.CrossRefGoogle Scholar
Cenedella, R. J. & Allen, A. (1969). Lipids 4, 155–158.CrossRefGoogle Scholar
Coniglio, J. G., Davis, J. T. & Aylward, S. (1964). Journal of Nutrition 84, 265–271.CrossRefGoogle Scholar
Coots, R. H. (1964). Journal of Lipid Research 5, 468–472.CrossRefGoogle Scholar
Coots, R. H. (1965). Journal of Lipid Research 6, 494–497.CrossRefGoogle Scholar
Crawford, M. A., Casperd, N. M. & Sinclair, A. J. (1976). Comparative Biochemistry and Physiology 54, 395–401.Google Scholar
Crawford, M. A., Doyle, W. & Drury, P. (1985). Tropical and Geographical Medicine 37, Suppl., 5–16.Google Scholar
Folch, J., Lees, M. & Stanley, G. H. (1957). Journal of Chemistry 226, 479–509.Google Scholar
Greenberg, N. J., Rodgers, J. B. & Isselbacher, K. J. (1965). Proceedings of the Society for Experimental Biology and Medicine 120, 468–472.CrossRefGoogle Scholar
Jones, P. J. H., Penzcharz, P. B. & Clandinin, M. T. (1985). American Journal of Clinical Nutrition 42, 769–777.CrossRefGoogle Scholar
Lazarow, P. B. & de Duve, C. (1976). Proceedings of the National Academy of Sciences, USA 73, 2043–2046.CrossRefGoogle Scholar
McDonald, G. B., Saunders, D. R., Weidman, M. & Fisher, L. (1980). American Journal of Physiology 239, 141–150.Google Scholar
Mead, J. F. (1971). Progress in the Chemistry of Fats and Lipids 9, 159–192.CrossRefGoogle Scholar
Mead, J. F., Slaton, W. H. & Decker, A. B. (1956). Journal of Biological Chemistry 218, 401–407.CrossRefGoogle Scholar
Ockner, R. K., Pittman, J. P. & Yager, J. P. (1972). Gastroenterology 62, 981–992.CrossRefGoogle Scholar
Rao, P. S. & Roa, K. S. (1973). Lipids 8, 374–377.CrossRefGoogle Scholar
Rizek, R. L., Welsh, S. O., Marston, R. M. & Jackson, E. M. (1983). In Dietary Fats and Health, pp. 13–43 [Perkins, E. G. and Visek, W. A., editors]. New York: American Oil Chemist's Society.Google Scholar
Sinclair, A. L. (1974). Lipids 9, 807–818.CrossRefGoogle ScholarPubMed
Weinman, E. O., Chaikoff, I. L., Dauben, W. G., Gee, M. & Enterman, C. (1950). Journal of Biological Chemistry 185, 735–744.CrossRefGoogle Scholar
Weinman, E. O., Chaikoff, I. L., Stevens, B. P. & Dauben, W. G. (1951). Journal of Biological Chemistry 191, 523–529.CrossRefGoogle Scholar
Willebrands, A. F. (1964). Biochimica et Biophysica Acta 84, 607–610.Google Scholar