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Distribution of copper and zinc in the liver of the developing sheep foetus

Published online by Cambridge University Press:  24 October 2018

I. Bremner ,
R. B. Williams  and
B. W. Young
I. Bremner
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
R. B. Williams
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
B. W. Young
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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  1. 1. A study has been made of the copper- and zinc-binding proteins in the livers from sheep foetuses of 80-142 d gestational age.

  2. 2. Metallothionein was found to constitute the major Zn-binding component in the cytosol at all times and to be identical to Zn-thionein from adult sheep liver.

  3. 3. Zn also occurred in two fractions, not normally found in sheep liver, with approximate molecular weights of 28000 and 47000. The relative proportions of these were age-dependent.

  4. 4. Between 15 and 35 % of the hepatic Cu, corresponding to most of the Cu in the cytosol, also occurred in the metallothionein-containing fraction.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 38 , Issue 1 , July 1977 , pp. 87 - 92
Copyright
Copyright © The Nutrition Society 1977

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