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Early post-hatching starvation delays p70 S6 kinase activation in the muscle of neonatal chicks

Published online by Cambridge University Press:  09 March 2007

Karine Bigot ,
Mohammed Taouis ,
Michel Picard  and
Sophie Tesseraud
Karine Bigot
Affiliation:
Régulation du Métabolisme des Oiseaux, Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Centre de Tours-Nouzilly, 37380 Nouzilly, France
Mohammed Taouis
Affiliation:
Régulation du Métabolisme des Oiseaux, Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Centre de Tours-Nouzilly, 37380 Nouzilly, France Laboratoire de Biologie Cellulaire et Moléculaire, Biotechnologies, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78352 Jouy-en-Josas, France
Michel Picard
Affiliation:
Régulation du Métabolisme des Oiseaux, Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Centre de Tours-Nouzilly, 37380 Nouzilly, France
Sophie Tesseraud*
Affiliation:
Régulation du Métabolisme des Oiseaux, Station de Recherches Avicoles, Institut National de la Recherche Agronomique, Centre de Tours-Nouzilly, 37380 Nouzilly, France
*
*Corresponding Author: Dr S. Tesseraud, fax +33 2 47 42 77 78, email tesserau@tours.inra.fr
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Abstract

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Chicken muscle ribosomal protein S6 kinase (S6K1) has been recently characterised and its enzymic activity is regulated by the nutritional and hormonal (insulin) status in vivo. The regulation of S6K1 is still unknown in neonatal chicks. The present study aimed to compare the activation of S6K1 in early-feeding (EF) and 48 h-delayed-feeding (DF) chicks from hatching to 4 d of age. During post-hatching starvation, S6K1 activity remained at the basal level measured in the control-hatched chicks. The maximum S6K1 activity was recorded on the first day of feeding with an increase of about 2·5-fold in the EF and DF chicks (P<0·01). S6K1 activity was correlated with plasma insulin level, suggesting a probable insulin-dependent S6K1 activation. The feeding-induced increase in S6K1 activity was related to its Thr389 residue phosphorylation. A similar pattern for protein kinase B phosphorylation was observed, upstream from S6K1. The S6K1 pathway was stimulated to the same extent in the EF and DF chicks, which indicates that post-hatching starvation did not increase S6K1 activation. It is concluded that muscle S6K1 is activated as soon as food is available without improvement in the response of the S6K1 pathway after post-hatching starvation.

Keywords

ChicksNeonatal feedingp70 S6 kinase activationSkeletal muscle
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 6 , December 2003 , pp. 1023 - 1029
Copyright
Copyright © The Nutrition Society 2003

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