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Effect of carbohydrate source on lipid metabolism in lactating mice and on pup development*

Published online by Cambridge University Press:  09 March 2007

Amal A. Ghusain-Choueiri  and
Elizabeth A. Rath
Amal A. Ghusain-Choueiri
Affiliation:
School of Biological Sciences, Queen Mary and Westfield College, London El 4NS
Elizabeth A. Rath
Affiliation:
School of Biological Sciences, Queen Mary and Westfield College, London El 4NS
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Abstract

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The effect of long-term sucrose intake on lipid metabolism and milk composition was examined in lactating mice and correlated with the development of their pups. Female mice were weaned onto semi-purified diets containing 685 g starch or sucrose/kg diet. Food intake was similar on the two diets. At mid-lactation, milk was collected and analysed. Milk from sucrose-fed dams had a lower percentage of linoleic acid (18:2n-6) and a higher percentage of oleic acid (18:ln-9), although milk fat content was similar. Hepatic fatty acid synthesis (as measured by 3H2O incorporation into fatty acid) was three times faster in sucrose-fed than in starch-fed dams. Dietary carbohydrate had no effect on fatty acid synthesis or functional lipoprotein lipase (EC 3.1.1.34) activity in mammary gland, nor on plasma triacylglycerol concentration. Pups from first litters were killed at 11–12 d and body composition analysed. Pups born to sucrose-fed dams were significantly heavier with increased body fat and higher levels of plasma glucose and triacylglycerol. Litters of sucrose- and starch-fed dams were cross-fostered at birth and killed at 10–12 d. Analysis of variance indicated that maternal sucrose intake, both during pregnancy and lactation, increased body fat of offspring. The increases in body weight and plasma triacylglycerol of pre-weaning offspring were caused primarily by maternal sucrose intake during lactation.

Keywords

SucroseMilkLipid metabolismPregnancyLactation
Type
Effect of carbohydrate intake on lipid metabolism
Information
British Journal of Nutrition , Volume 74 , Issue 6 , December 1995 , pp. 821 - 831
Copyright
Copyright © The Nutrition Society 1995

References

Ailing, C, Cahlin, E. & Schersten, T. (1973). Relationships between fatty acid patterns of serum, hepatic and biliary lecithins in man: effects of sucrose feeding. Biochimica et Biophysica Acta 296, 518–526.CrossRefGoogle Scholar
Babicky, A., Ostadalova, I., Parizek, J., Kolar, J. & Bibr, B. (1970). Use of radioisotope techniques for determining the weaning period in experimental animals. Physiologia Bohemoslovenica 19, 457–467.Google ScholarPubMed
Baltzell, J. K. & Berdanier, C. D, (1985). Effect of the interaction of dietary carbohydrate and fat on the responses of rats to starvation-refeeding. Journal of Nutrition 115, 104–110.CrossRefGoogle ScholarPubMed
Berdanier, C. D. (1975). Effect of maternal sucrose intake on the metabolic patterns of mature rat progeny. American Journal of Clinical Nutrition 28, 1416–1421.CrossRefGoogle ScholarPubMed
Berdanier, C. D. (1987). Interacting effects of carbohydrate and lipid on metabolism. In Nutrient Interactions, pp. 265–285. New York: Marcel Dekker Inc.Google Scholar
Berdanier, C. D., Tobin, R. B. & DeVore, V. (1979). Effects of age, strain and dietary carbohydrate on the hepatic metabolism of male rats. Journal of Nutrition 109, 261–271.CrossRefGoogle ScholarPubMed
Bonnevie-Nielson, V. (1980). Experimental diets affect pancreatic insulin and glucagon differently in male and female mice. Metabolism 29, 386–391.CrossRefGoogle Scholar
Bouillon, D. J. & Berdanier, C. D. (1983). Effect of maternal carbohydrate intake on mitochondrial activity and on lipogenesis by the young and mature progeny. Journal of Nutrition 113, 2205–2216.CrossRefGoogle Scholar
Chow, B. F., Blackwell, R. Q., Blackwell, B. M., How, T. Y., Aliane, J. K. & Sherwin, R. N. (1968). Maternal nutrition and metabolism of the offspring: studies in rats and man. American Journal of Public Health 58, 668–677.CrossRefGoogle ScholarPubMed
Chow, B. F. & Lee, C. J. (1964). Effect of dietary restriction of pregnant rats on body weight gain of the offspring. Journal of Nutrition 82, 10–18.CrossRefGoogle ScholarPubMed
Christon, R., Fernandez, Y., Cambon-Gros, C, Periquet, A., Deltour, P., Leger, C. L. & Mitjavila, S. (1988). The effect of dietary essential fatty acid deficiency on the composition and properties of the liver microsomal membrane of rats. Journal of Nutrition 118, 1311–1318.CrossRefGoogle ScholarPubMed
Clandinin, M. T., Cheema, S., Field, C. J. & Baracos, V. E. (1993). Dietary lipids influence insulin action. Annals of the New York Academy of Sciences 683, 151–163.CrossRefGoogle ScholarPubMed
Cohen, A.M. (1986). Metabolic responses to dietary carbohydrates: interactions of dietary and hereditary factors. Progress in Biochemical Pharmacology 21, 74–103.Google ScholarPubMed
Cohen, A. M., Bavly, S. & Poznanski, R. (1961). Change of diet of Yemenite Jews in relation to diabetes and ischaemic heart-disease. Lancet ii, 1399–1401.CrossRefGoogle Scholar
Cohen, A. M., Teitelbaum, A. & Saliternik, R. (1972). Genetics and diet as factors in development of diabetes mellitus. Metabolism 21, 235–240.CrossRefGoogle Scholar
Cryer, A. & Jones, H. M. (1979). The early development of white adipose tissue. Biochemical Journal 178, 711–724.CrossRefGoogle ScholarPubMed
Da Silva, L. A., De Marcucci, O. L. & Kuhnle, Z. R. (1993). Dietary polyunsaturated fats suppress the high-sucrose-induced increase of rat liver pyruvate dehydrogenase levels. Biochimica et Biophysica Acta 1169, 126–134.CrossRefGoogle ScholarPubMed
Davies, R. L., Hargen, S. E., Yeomans, F. M. & Chow, B. F. (1973). Long term effects of alterations of maternal diet in mice. Nutrition Reports International 7, 463–473.Google Scholar
Davies, R. L., Hargen, S. M. & Chow, B. F. (1972). The effect of maternal diet on the growth of metabolic patterns of progeny. Nutrition Reports International 6, 1–7.Google Scholar
de Pury, G. G. & Collins, F. D. (1972). Very low density lipoproteins and lipoprotein lipase in serum of rats deficient in essential fatty acids. Journal of Lipid Research 13, 268–275.CrossRefGoogle ScholarPubMed
Eckel, R. H., Fujimoto, W. Y. & Brunzell, J. D. (1979). Gastric inhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes. Diabetes 28, 1141–1142.CrossRefGoogle ScholarPubMed
Fears, R. (1978). Measurement of cholesterol biosynthesis in vivo with tritiated water. Biochemical Society Transactions 6, 871–874.CrossRefGoogle ScholarPubMed
Field, C. J., Ryan, E. A., Thomson, A. B. & Clandinin, M. T. (1990). Diet fat composition alters membrane phospholipid composition, insulin binding and glucose metabolism in adipocytes from control and diabetic animals. Journal of Biological Chemistry 265, 11143–11150.CrossRefGoogle ScholarPubMed
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957). A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226, 497–509.CrossRefGoogle ScholarPubMed
Hanrahan, J. P. & Eisen, E. J. (1970). A lactation curve for mice. Laboratory Animal Care 20, 101–104.Google ScholarPubMed
Jeffcoat, R. & James, A. T. (1977). Interrelationship between the dietary regulation of fatty acid synthesis and the fatty acyl-CoA desaturases. Lipids 12, 469–474.CrossRefGoogle ScholarPubMed
Jeffcoat, R. & James, A. T. (1978). The control of stearoyl-CoA desaturase by dietary linoleic acid. FEBS Letters 85, 114–118.CrossRefGoogle ScholarPubMed
Kochan, Z. & Swierczyiiski, J. (1992). Development changes of lipogenic enzyme activities and lipogenesis in brown adipose tissue and liver of the rat. Comparative Biochemistry and Physiology 101, 283–288.Google ScholarPubMed
Krebs, H. A., Dierkes, C. & Gascioyne, T. (1964). Carbohydrate synthesis from lactate in pigeon liver homogenates. Biochemical Journal 93, 112–121.CrossRefGoogle Scholar
Kwasowski, P., Flatt, P. R., Bailey, C. J. & Marks, V. (1985). Effects of fatty acid chain length and saturation on gastric inhibitory polypeptide release in obese hyperglycaemic (ob/ob) mice. Bioscience Reports 5, 701–705.CrossRefGoogle ScholarPubMed
MacDonald, I. & Braithwaite, D. (1964). The influence of dietary carbohydrates on the lipid pattern in serum and in adipose tissue. Clinical Science 27, 23–30.Google ScholarPubMed
McGandy, R. B., Hegsted, D. M., Myers, M. L. & Stare, F. J. (1986). Dietary carbohydrate and serum cholesterol levels in man. American Journal of Clinical Nutrition 18, 237–242.CrossRefGoogle Scholar
Mann, J. I., Watermeyer, G. S., Manning, E. B., Randies, J. & Truswell, A. S. (1973). Effects on serum lipids of different dietary fats associated with a high sucrose diet. Clinical Science 44, 601–604.CrossRefGoogle ScholarPubMed
Marks, V. (1988). GIP-the obesity hormone. In Current Approaches to Obesity, pp. 13–19. Southampton: Dulphar Medical Relations.Google Scholar
Marshall, M. W. & Hildebrand, H. E. (1963). Differences in rat strain response to three diets of different composition. Journal of Nutrition 79, 227–238.CrossRefGoogle Scholar
Meier, H., Hoag, W. G. & McBumey, J. J. (1965). Chemical characterization of inbred-strain mouse milk. I. Gross composition and amino acid analysis. Journal of Nutrition 85, 305–308.CrossRefGoogle Scholar
Mellies, M. J., Ishikawa, T. T., Gartside, P. S., Burton, K., MacGee, J., Allen, K., Steiner, P. M., Brady, D. & Glueck, C. J. (1979). Effects of varying maternal dietary fatty acids in lactating women and their infants. American Journal of Clinical Nutrition 32, 229–303.CrossRefGoogle ScholarPubMed
Rath, E. A., Salmon, D. M. W. & Hems, D. A. (1979). Effect of acute change in ambient temperature on fatty acid synthesis in the mouse. FEBS Letters 108, 33–36.CrossRefGoogle ScholarPubMed
Rath, E. A. & Thenen, S. W. (1979). Use of tritiated water for measurement of 24-hour milk intake in suckling lean and genetically obese (ob/ob) mice. Journal of Nutrition 109, 840–847.CrossRefGoogle ScholarPubMed
Reiser, S. (1982). Metabolic risk factors associated with heart disease and diabetes in carbohydrate-sensitive humans when consuming sucrose as compared to starch. In Metabolic Effects of Utilizable Dietary Carbohydrates, pp. 239–254. New York: Marcel Dekker Inc.Google Scholar
Reiser, S., Hallfrisch, J., Michaelis, O. E., Lazar, F. L., Martin, R. E. & Prather, E. S. (1979 a). Isocaloric exchange of dietary starch and sucrose in humans: I. Effects on levels of fasting blood lipids. American Journal of Clinical Nutrition 32, 1659–1669.CrossRefGoogle ScholarPubMed
Reiser, S., Handler, H. B., Gardner, L. B., Hallfrisch, J. G., Michaelis, O. E. & Prather, E. S. (1979 b). Isocaloric exchange of dietary starch and sucrose in humans: II. Effects on fasting blood insulin, glucose, and glucagons and on insulin and glucose response to a sucrose load. American Journal of Clinical Nutrition 32, 2206–2216.CrossRefGoogle ScholarPubMed
Roberts, S. B. & Coward, W. A. (1985). Dietary supplementation increases milk output in the rat. British Journal of Nutrition 53, 1–9.CrossRefGoogle ScholarPubMed
Rolls, B. J., Edwards-Webb, J. D., Gurr, M. I., Rolls, B. A. & Rowe, E. A. (1981). The influence of dietary obesity on milk composition in the rat. Proceedings of the Nutrition Society 40, 60A.Google Scholar
Salaman, M. R. & Robinson, D. S. (1966). Clearing factor lipase in adipose tissue. Biochemical Journal 99, 640–647.CrossRefGoogle ScholarPubMed
Smith, S. & Abraham, S. (1970). Fatty acid synthesis in developing mouse liver. Archives of Biochemistry 136, 112–121.CrossRefGoogle ScholarPubMed
Smith, S., Gagne, H. T., Pitelike, D. R. & Abraham, S. (1969). The effect of dietary fat on lipogenesis in mammary gland and liver from lactating and virgin mice. Biochemical Journal 115, 807–815.CrossRefGoogle ScholarPubMed
Srivastava, U., Vu, M. & Goswami, T. (1974). Maternal dietary deficiency and cellular development of progeny in the rat. Journal of Nutrition 104, 512–520.CrossRefGoogle ScholarPubMed
Taylor, C. B., Bailey, E. & Bartley, W. (1967). Changes in hepatic lipogenesis during development of the rat. Biochemical Journal 105, 717–722.CrossRefGoogle ScholarPubMed
Van Duijvervoorde, P. M. & Rolls, B. J. (1985). Body fat regulation during pregnancy and lactation: the roles of diet and insulin. Biochemical Society Transactions 13, 824–825.CrossRefGoogle Scholar
Van Handle, E. & Zilversmit, D. B. (1957). Micromethod for the direct determination of serum triglycerides. Journal of Laboratory and Clinical Medicine 50, 152–157.Google Scholar
Vrana, A., Fabry, P. & Kazdova, L. (1974). Lipoprotein lipase activity in heart diaphragm and adipose tissue in rats fed various carbohydrates. Nutrition and Metabolism 17, 282–288.CrossRefGoogle ScholarPubMed
Wander, R. C. & Berdanier, C. D. (1985). Effects of dietary carbohydrate on mitochondrial composition and function in two strains of rats. Journal of Nutrition 115, 190–196.CrossRefGoogle ScholarPubMed
Wasada, T., McCorkle, K., Harris, V., Kawai, K., Howard, B. & Unger, R. H. (1981). Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs. Journal of Clinical Investigation 68, 1106–1107.CrossRefGoogle ScholarPubMed
Wieland, O. (1963). Glycerol. In Methods of Enzymatic Analysis, pp. 211–214. New York: Academic Press.Google Scholar
Winand, J., Hebbelinck, M., Wodon, C. & Christopher, J. (1976). Influence of litter size on lipid composition in infant mice. Nutrition and Metabolism 20, 289–301.CrossRefGoogle ScholarPubMed
Wise, A. (1982). Interaction of diet and toxicity for future role of purified diet in toxicological research. Archives of Toxicology 50, 278–299.Google ScholarPubMed
Worcester, N. A., Bruckdorfer, K. R., Hallinan, T., Wilkins, A. J., Mann, J. A. & Yudkin, J. (1979). The influence of diet and diabetes on stearoyl coenzyme A desaturase (EC 1·14.99·5) activity and fatty acid composition in rat tissues. British Journal of Nutrition 41, 239–252.CrossRefGoogle Scholar
Yamini, S., Staples, R. C, Hansen, C. T. & Szepesi, B. (1991). Effect of dietary carbohydrate on liver and kidney enzyme activities and plasma amino acids in the LA/N-cp rat. International Journal of Obesity 15, 189–203.Google ScholarPubMed
Yudkin, J. (1964). Patterns and trends in carbohydrate consumption and their relation to disease. Proceedings of the Nutrition Society 23, 149–162.CrossRefGoogle ScholarPubMed
Zeman, F. J. (1969). Effect of protein deficiency during gestation on postnatal cellular development in the young rat. Journal of Nutrition 100, 530–538.CrossRefGoogle Scholar