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Effect of dietary supply of butters rich either in trans-10-18:1 or in trans-11-18:1 plus cis-9, trans-11-18:2 on rabbit adipose tissue and liver lipogenic activities

Published online by Cambridge University Press:  19 February 2008

Yannick Faulconnier ,
Alexandre Roy ,
Anne Ferlay ,
Jean-Michel Chardigny ,
Denys Durand ,
Stephanie Lorenz ,
Dominique Gruffat  and
Yves Chilliard
Yannick Faulconnier
Affiliation:
INRA, Herbivore Research Unit, 63122 Saint Genès-Champanelle, France
Alexandre Roy
Affiliation:
INRA, Herbivore Research Unit, 63122 Saint Genès-Champanelle, France INRA-Université d'Auvergne, Human Nutrition Unit, 63001 Clermont-Ferrand, France
Anne Ferlay
Affiliation:
INRA, Herbivore Research Unit, 63122 Saint Genès-Champanelle, France
Jean-Michel Chardigny
Affiliation:
INRA-Université d'Auvergne, Human Nutrition Unit, 63001 Clermont-Ferrand, France
Denys Durand
Affiliation:
INRA, Herbivore Research Unit, 63122 Saint Genès-Champanelle, France
Stephanie Lorenz
Affiliation:
INRA, Herbivore Research Unit, 63122 Saint Genès-Champanelle, France
Dominique Gruffat
Affiliation:
INRA, Herbivore Research Unit, 63122 Saint Genès-Champanelle, France
Yves Chilliard*
Affiliation:
INRA, Herbivore Research Unit, 63122 Saint Genès-Champanelle, France
*
*Corresponding author: Dr Yves Chilliard, fax +33 473 62 45 19, email yves.chilliard@clermont.inra.fr
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Abstract

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Experimental butters with a high content of trans-18:1 fatty acids an/r cis-9,trans-11-18:2 (rumenic acid; RA) were fed to thirty-six New Zealand White rabbits to investigate their effects on adipose tissue (AT) and liver lipogenic activities. Animals received one of three atherogenic (0·2% cholesterol) diets containing 12% butter with either a standard fatty acid composition (rich in saturated fatty acids), rich in trans-10-18:1 (T10 diet) or in trans-11-18:1 plus RA (T11+ RA diet) for 6 or 12 weeks. The ingestion of butters rich in trans fatty acids an/r RA for 6 weeks had little or no effect on liver and AT lipogenesis. The ingestion for 12 weeks of butter rich in T11 + RA decreased perirenal AT weight, lipogenic enzyme and lipoprotein lipase activities, without affecting liver lipid concentration or lipogenic activities except for a decrease in glycerol-3-phosphate dehydrogenase activity. Similar trends, but of a lower magnitude, were observed in rabbits fed the T10 diet for 12 weeks. Ingestion of the T10 or T11 + RA diets for 6 or 12 weeks had no significant effect on plasma metabolites and hormones except for glucose which increased at 6 weeks in the T10 group. Plasma leptin concentration was positively correlated with AT weight but did not differ between the three diets. In conclusion, the supply of butters rich in either T10 or T11 + RA in an atherogenic diet for 12 weeks decreased rabbit AT lipogenesis, with a more marked effect of the T11 + RA diet, but had no effect on liver lipogenesis.

Keywords

Trans fatty acidsLipogenesisAdipose tissueLiverRabbits
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 3 , September 2006 , pp. 461 - 468
Copyright
Copyright © The Nutrition Society 2006

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