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Effect of insulin-like growth factor-I on nitrogen balance and intestinal galactose transport in rats with moderate liver cirrhosis

Published online by Cambridge University Press:  09 March 2007

Marina Núñez ,
Elena Urdaneta  and
Santiago Santidrián
Marina Núñez
Affiliation:
Department of Human Physiology, School of Medicine, University of Navarra, 31008 Pamplona, Spain Department of Internal Medicine, School of Medicine, University of Navarra, 31008 Pamplona, Spain
Elena Urdaneta
Affiliation:
Department of Natural Sciences, School of Agronomy, Public University of Navarra, 31006 Pamplona, Spain
Santiago Santidrián*
Affiliation:
Department of Human Physiology, School of Medicine, University of Navarra, 31008 Pamplona, Spain
*
*Corresponding author: Dr Santiago Santidrián, fax +34 948 425649, email santidrian@unav.es
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Abstract

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The malnutrition caused by liver cirrhosis (LC) often worsens the course of the disease. Patients affected by LC often have a low bioavailability of the anabolic liver peptide insulin-like growth factor (IGF)-I. The present study was undertaken to investigate the effect of low doses of IGF-I on the nutritional status and in vivo jejunal transport of d-galactose in anatomically, pathologically and biochemically confirmed moderate, non-ascitic, cirrhotic rats. LC was experimentally induced in growing rats by inhalation of CCl4 and addition of phenobarbital to drinking water. Both the nutritional status, as evaluated by N balance, and in vivo intestinal transport of d-galactose, were significantly impaired in cirrhotic rats. As compared with healthy rats, administration of 20μg human recombinant IGF-I/kg body weight for 14d to cirrhotic rats significantly improved N balance variables and restored in vivo intestinal transport of the sugar. However, IGF-I had no effect on the steatorrhoea associated with LC. These results suggest that low doses of IGF-I may have beneficial effects on the malnutrition associated with moderate LC.

Keywords

CirrhosisInsulin-like growth factor-INitrogen balanceIntestinal absorption
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 5 , November 2003 , pp. 929 - 937
Copyright
Copyright © The Nutrition Society 2003

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