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Effect of protein restriction on messenger RNA of insulin-like growth factor-I and insulin-like growth factor-binding proteins in liver of ovariectomized rats

Published online by Cambridge University Press:  09 March 2007

Yusuke Higashi ,
Asako Takenaka ,
Shin-Ichiro Takahashi  and
Tadashi Noguchi
Yusuke Higashi
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyoku, Tokyo 113, Japan
Asako Takenaka
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyoku, Tokyo 113, Japan
Shin-Ichiro Takahashi
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyoku, Tokyo 113, Japan
Tadashi Noguchi*
Affiliation:
Laboratory of Nutritional Biochemistry, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyoku, Tokyo 113, Japan
*
§Corresponding author: Dr Tadashi Noguchi, fax +81 3 3812 0544, email noguchi@eiyo.m.u-tokyo.ac.jp
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Abstract

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Effects of dietary protein restriction and ovariectomy on plasma concentrations and hepatic messenger RNA (mRNA) of insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding proteins (IGFBP) were investigated in young female rats. Ovariectomy increased plasma IGF-I concentration in rats fed on either a 50 g casein/kg diet (protein-restricted diet) or a 200 g casein/kg diet (control diet), but it increased IGF-I mRNA in liver only in the rats fed on the control diet. On the other hand, by Western ligand blot analysis, we observed that ovariectomy increased plasma IGFBP-3 concentration, and decreased plasma IGFBP-4 concentration. Ovariectomy did not affect IGFBP-1 and IGFBP-2 mRNA in liver, but dietary protein restriction significantly increased them, which may correspond to their plasma concentrations. The present results show that ovarian hormones and dietary protein content affect the plasma concentrations of IGF-I, IGFBP-3 and IGFBP-4 and hepatic mRNA of IGF-I, IGFBP-1, IGFBP-2, IGFBP-3 and IGFBP-4 in different manners.

Keywords

Insulin-like growth factor-IInsulin-like growth factor-binding proteinsProtein restrictionOvariectomy
Type
General Nutrition
Information
British Journal of Nutrition , Volume 79 , Issue 5 , May 1998 , pp. 447 - 453
Copyright
Copyright © The Nutrition Society 1998

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