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Effect of some gastrointestinal hormones on motor and electrical activity of the digestive tract in the conscious cat

Published online by Cambridge University Press:  09 March 2007

Maurice Rochei ,
Monique Descroix-Vagne ,
Sonia Benouali  and
Jean-Alain Chayvialle
Maurice Rochei
Affiliation:
Laboratoire de Physiologie Appliquée et Pharmacologie, Université de Savoie, BP 1104. 73011, Chambéry, France
Monique Descroix-Vagne
Affiliation:
INSERM, Unité, 45, Hôpital E. Herriot, Lyon, France
Sonia Benouali
Affiliation:
Laboratoire de Physiologie Appliquée et Pharmacologie, Université de Savoie, BP 1104. 73011, Chambéry, France
Jean-Alain Chayvialle
Affiliation:
INSERM, Unité, 45, Hôpital E. Herriot, Lyon, France
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Abstract

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Three peptides structurally related to gastrin and known to be full agonists of antral motility in the conscious cat, pentagastrin (PG), cholecystokinin (CCK) and synthetic octapeptide of cholecystokinin (OP-CCK), were compared in relation to antral and duodenal electrical activity. They induced the same antral effect in eliciting an increase in the basal electrical rhythm (BER) and a short-lasting decrease in the frequency of the bursts of spikes. The electrical changes were correlated with lumen pressure changes measured in parallel, consisting of a decrease in the frequency of high-amplitude peaks and an increase in low-amplitude peaks. The additive effect of PG and CCK shows that the peptides are full agonists for antral electrical activity, as they are for antral motility and acid secretion. In contrast to the antrum, the three peptides increased the frequency of the duodenal spike bursts, CCK and OP-CCK decreased the BER frequency, while PG increased BER slightly. The increase in antral and duodenal BER obtained after a beef-liver meal, which produced a large endogenous gastrin release, suggests a major role for gastrin in antral motility induced by feeding, at least in the cat.

Keywords

Gastrointestinal hormonesMotor and electrical activity
Type
Gastrointestinal Hormones and Intestinal Motility
Information
British Journal of Nutrition , Volume 69 , Issue 2 , March 1993 , pp. 371 - 384
Copyright
Copyright © The Nutrition Society 1993

References

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