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The effect of zinc deficiency on glucose metabolism in meal-fed rats*

Published online by Cambridge University Press:  09 March 2007

Philip G. Reeves  and
Boyd L. O'Dell
Philip G. Reeves
Affiliation:
322 Chemistry, Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
Boyd L. O'Dell
Affiliation:
322 Chemistry, Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
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Abstract

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1. The incorporation of uniformly-labelled [14C]glucose into fatty acids and glycogen of adipose tissue and liver was used to assess the effects of zinc deficiency on glucose metabolism in meal-fed rats.

2. Throughout the study, identical feeding regimens were maintained between each of the Zn-deficient groups and their appropriate controls. The feeding regimens were either meal-feeding or ad lib. feeding.

3. Zn deficiency reduced [14C]glucose incorporation into fatty acids of epididymal fat pads of meal-fed rats by 75% when compared with meal-fed controls.

4. Zn deficiency caused a slight but significant decrease in [14C]glucose incorporation into liver fatty acids of meal-fed fats when compared with meal-fed controls.

5. Zn deficiency significantly increased [14C]glucose incorporation into liver glycogen of meal-fed rats in Expt. 2 but not in Expt 1.

6. Some effects of Zn deficiency on glucose metabolism were shown to be independent of the feeding regimen when a single daily meal was given to both Zn deficient and control groups. This method of feeding may be a useful approach to study the effects of Zn on glucose metabolism in the rat.

Type
Paper on General Nutrition
Information
British Journal of Nutrition , Volume 49 , Issue 3 , May 1983 , pp. 441 - 452
Copyright
Copyright © The Nutrition Society 1983

References

Brown, E. D., Penhos, J. C., Recant, L. & Smith, J. C. Jr. (1975). Proc. Soc. expl. Biol. Med. 150, 557.Google Scholar
Cahill, G. F. Jr, Ashmore, J., Earle, A. S. & Zottur, S. (1958). Am. J. Physiol. 192, 491.CrossRefGoogle Scholar
Goodnight, J. H. & Sall, J. P. (1979). In Statistical Analysis User's Guide, p. 121 [Helwig, J. T. and Council, D. A., editors]. Cary, NC: SAS Institute Inc.Google Scholar
Hendricks, D. G. & Mahoney, A. W. (1972). J. Nutr. 102, 1079.CrossRefGoogle Scholar
Huber, A. M. & Gershoff, S. N. (1973). J. Nutr. 103, 1739.CrossRefGoogle Scholar
Laurell, S. & Tibbling, G. (1967). Clinica. chim. Acta 16, 57.CrossRefGoogle Scholar
Leveille, G. A. (1967). Proc. Soc. expl. Biol. Med. 125, 85.CrossRefGoogle Scholar
Mulmed, L. N., Gannon, M. C., Gilboe, D. P., Tan, A. W. H. & Nuttall, F. Q. (1979). Diabetes 28, 231.CrossRefGoogle Scholar
O'Dea, K. & Puls, W. (1979). Metabolism 28, 308.CrossRefGoogle Scholar
O'Dell, B. L., Burpo, C. E. & Savage, J. E. (1972). J. Nutr. 102, 653.Google Scholar
Palmquist, D. L., Learn, D. B. & Baker, N. (1977). J. Nutr. 107, 502.Google Scholar
Quarterman, J. (1969). Biochim. biophys. Acta 177, 644.CrossRefGoogle Scholar
Quarterman, J. & Florence, E. (1972). Br. J. Nutr. 28, 75.Google Scholar
Quarterman, J., Mills, C. F. & Humphries, W. R. (1966). Biochem. Biophys. Res. Commun. 25, 354.CrossRefGoogle Scholar
Renold, A. E., Hastings, A. B., Nesbett, F. B. & Ashmore, J. (1955). J. biol. Chem. 213, 135.CrossRefGoogle Scholar
Roth, H.-P. & Kirchgessner, M. (1975). Int. Z. Vit. Ern. Forsch. 45, 201.Google Scholar
Roth, H.-P. & Kirchgessner, M. (1979). Z. Tierphysiol. Tierernahrung. Futtermittelkde 42, 287.CrossRefGoogle Scholar
Roth, H.-P., Schneider, U. & Kirchgessner, M. (1975). Archs. Tierernahrung. 25, 545.Google Scholar
Van Handel, E. (1965). Analyt. Biochem. 11, 256.CrossRefGoogle Scholar
Wiley, J. N. & Leveille, G. A. (1970). J. Nutr. 100, 1073.Google Scholar