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Effects of arginine-containing total parenteral nutrition on N balance and phagocytic activity in rats undergoing a partial gastrectomy

Published online by Cambridge University Press:  08 March 2007

Chiu-Li Yeh ,
Chen-Hsien Lee ,
Soul-Chin Chen ,
Yu-Chen Hou  and
Sung-Ling Yeh
Chiu-Li Yeh
Affiliation:
Institute of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan
Chen-Hsien Lee
Affiliation:
Institute of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan
Soul-Chin Chen
Affiliation:
Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan
Yu-Chen Hou
Affiliation:
Institute of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan
Sung-Ling Yeh*
Affiliation:
Institute of Nutrition and Health Sciences, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan
*
*Corresponding author: Dr Sung-Ling Yeh, fax +886 2 27373112, email sangling@tmu.edu.tw
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Abstract

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The present study investigated the effect of arginine (Arg)-containing parenteral nutrition on phagocytic activity to elucidate the possible roles of Arg in the secretion of anabolic hormones and N balance in rats undergoing gastrectomy. Rats were divided into two experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN, the other group replaced 2 % of the total energy as Arg. After receiving TPN for 3 d, one-third of the rats in each experimental group were killed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 or 3 d after surgery. The results showed that there were no differences in N balance, plasma growth hormone and insulin-like growth factor-1 levels between the two groups before or after surgery. The phagocytic activity of peritoneal macrophages was higher in the Arg group than in the control group 1 d after surgery. There were no differences in the phagocytic activities of blood polymorphonuclear neutrophils between the two groups at various time points. TNF-α levels in peritoneal lavage fluid were lower in the Arg group than in the control group on post-operative day 3. These results suggest that parenterally infused Arg enhances phagocytic activity and reduces the production of inflammatory mediators at the site of injury. However, Arg supplementation did not influence the secretion of anabolic hormones nor N balance in rats with a partial gastrectomy.

Keywords

ArginineGastrectomyPhagocytosisNitrogen balance
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 2 , February 2005 , pp. 267 - 272
Copyright
Copyright © The Nutrition Society 2005

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