Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-13T12:12:43.707Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of dietary copper deficiency on male offspring of heterozygous brindled mice

Published online by Cambridge University Press:  09 March 2007

Joseph R. Prohaska
Joseph R. Prohaska
Affiliation:
Department of Biochemistry, University of Minnesota, Duluth, Minnesota 55812, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Female C57BL mice heterozygous for the brindled gene were mated to normal males and fed on a purified diet low in copper throughout gestation and lactation with (+ Cu) or without (−Cu) Cu-supplemented drinking water. Male offspring of two genotypes (control, + /y and brindled, Mobr/y) were compared when 10–12 d old. Brindled mice from dams on the – Cu treatment were smaller and had lower packed cell volumes than brindled mice from dams on the + Cu treatment. The −Cu brindled mice were smaller than their littermate brothers (+/y) but had equivalent biochemical features consistent with severe Cu deficiency. Compared with control mice from dams on the +Cu treatment, caeruloplasmin (EC 1.16.3.1) activity was lower in offspring of all three other groups including Mobr/y mice who were not anaemic. Iron levels were similar in organs and bone marrow from all four groups of offspring. When dietary Cu is limiting in brindled mice a more severe Cu deficiency ensues. Thus, appropriate Cu nutriture is important to the management of Menkes' disease in humans, a genetic analogue of the brindled mouse.

Keywords

Copper deficiencyBrindled mouse
Type
Research Article
Information
British Journal of Nutrition , Volume 62 , Issue 1 , July 1989 , pp. 177 - 184
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

Aguillar, J.J., Chadwick, D.L., Okuyama, K. & Kamoshita, S. (1966). Kinky hair disease. I. Clinical and pathological features. Journal of Neuropathology and Experimental Neurology 25, 507–522.CrossRefGoogle Scholar
American Institute of Nutrition (1977). Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. Journal of Nutrition 107, 1340–1348.Google Scholar
Baker, E., Morton, A.G. & Tavill, A.S. (1980). The regulation of iron release from the perfused rat liver. British Journal of Haematology 45, 607–620.Google Scholar
Bush, J.A., Jensen, W.N., Athens, J.W., Ashenbruker, H., Cartwright, G.E. & Wintrobe, M.M. (1956). Studies on copper metabolism. XIX. The kinetics of iron metabolism and erythrocyte life-span in copper-deficient swine. Journal of Experimental Medicine 103, 701–712.CrossRefGoogle ScholarPubMed
Camakaris, J., Mann, J.R. & Danks, D.M. (1979). Copper metabolism in mottled mouse mutants. Copper concentrations in tissues during development. Biochemical Journal 180, 597–604.Google Scholar
Cohen, N.L., Keen, C.L., Lönnerdahl, B. & Hurley, L.S. (1985). Effects of varying dietary iron on the expression of copper deficiency in the growing rat: anemia, ferroxidase I and II, tissue trace elements, ascorbic acid, and xanthine dehydrogenase. Journal of Nutrition 115, 633–649.Google Scholar
Danks, D.M. (1988). Copper deficiency in humans. Annual Review of Nutrition 8, 235–257.CrossRefGoogle ScholarPubMed
Dorn, G., Neuhäuser, G., Heye, D. & Kielhorn, A. (1973). Das kinky-hair-syndrom von Menkes. Klinische Pädiatrie 185, 480–489.Google ScholarPubMed
Evans, J.L. & Abraham, P.A. (1973). Anemia, iron storage and ceruloplasmin in copper nutrition in the growing rat. Journal of Nutrition 103, 196–201.CrossRefGoogle ScholarPubMed
Fields, M., Ferretti, R.J., Smith, J.C. Jr & Reiser, S. (1984). The interaction of type of dietary carbohydrates with copper deficiency. American Journal of Clinical Nutrition 39, 289–295.Google ScholarPubMed
Fields, M., Lewis, C.G., Beal, T., Scholfield, D., Patterson, K., Smith, J.C. & Reiser, S. (1987). Sexual differences in the expression of copper deficiency in rats. Proceedings of the Society for Experimental Biology and Medicine 186, 183–187.CrossRefGoogle ScholarPubMed
Hunt, D.M. (1974). Primary defect in copper transport underlies mottled mutants in the mouse. Nature 249, 852–854.CrossRefGoogle ScholarPubMed
Johnson, M.A. & Hove, S.S. (1986). Development of anemia in copper-deficient rats fed high levels of dietary iron and sucrose. Journal of Nutrition 116, 1225–1238.CrossRefGoogle ScholarPubMed
Lott, R.T., DiPaolo, R., Schwartz, D., Janowska, S. & Kanfer, J.N. (1975). Copper metabolism in the steely-hair syndrome. New England Journal of Medicine 292, 197–199.CrossRefGoogle ScholarPubMed
Lukasewycz, O.A., Kolquist, K.L. & Prohaska, J.R. (1987). Splenocytes from copper-deficient mice are low responders and weak stimulators in mixed lymphocyte reactions. Nutrition Research 7, 43–52.Google Scholar
Mann, J.R., Camakaris, J. & Danks, D.M. (1980). Copper metabolism in mottled mouse mutants. Defective placental transfer of 64Cu to foetal brindled (Mobr) mice. Biochemical Journal 186, 629–631.Google Scholar
Markwell, M.A.K., Haas, S.M., Bieber, L.L. & Tolbert, N.E. (1978). Modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Analytical Biochemistry 87, 206–210.CrossRefGoogle ScholarPubMed
Mills, C.F. (1980). Metabolic interactions of copper with other trace elements. In Biological Roles of Copper, pp. 49–69 [Evered, D. and Lawrenson, G., editors]. Oxford; Excerpta Medica.Google ScholarPubMed
Osaki, S., Johnson, D.A. & Frieden, E. (1966). The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. Journal of Biological Chemistry 241, 2746–2751.Google Scholar
Osaki, S., Johnson, D.A. & Frieden, E. (1971). The mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxidase. I. Journal of Biological Chemistry 246, 3018–3023.Google Scholar
Prohaska, J.R. (1981). Comparison between dietary and genetic copper deficiency in mice: copper-dependent anemia. Nutrition Research 1, 159–167.CrossRefGoogle Scholar
Prohaska, J.R. (1983). Changes in tissue growth, concentrations of copper, iron, cytochrome oxidase and superoxide dismutase subsequent to dietary or genetic copper deficiency in mice. Journal of Nutrition 113, 2048–2058.Google Scholar
Prohaska, J.R. (1984). Repletion of copper-deficient mice and brindled mice with copper or iron. Journal of Nutrition 114, 422–430.Google Scholar
Prohaska, J.R. (1986). Genetic diseases of copper metabolism. Clinical Physiology and Biochemistry 4, 87–93.Google ScholarPubMed
Prohaska, J.R. (1988a). Biochemical functions of copper in animals. In Essential and Toxic Trace Elements in Human Health and Disease, pp. 105–124 [Prasad, A.S., editor]. New York: Alan R. Liss.Google Scholar
Prohaska, J.R. (1988b). Effect of dietary copper deficiency on heterozygous female brindled mice. Nutrition Research 8, 1079–1084.Google Scholar
Prohaska, J.R. & Lukasewycz, O.A. (1981). Copper deficiency suppresses the immune response of mice. Science 213, 559–561.CrossRefGoogle ScholarPubMed
Prohaska, J.R. & Smith, T.L. (1982). Effect of dietary or genetic copper deficiency on brain catecholamines, trace metals and enzymes in mice and rats. Journal of Nutrition 112, 1706–1717.Google Scholar
Roeser, H.P., Lee, G.R., Nacht, S. & Cartwright, G.E. (1970). The role of ceruloplasmin in iron metabolism. Journal of Clinical Investigation 49, 2408–2417.CrossRefGoogle ScholarPubMed
Shokeir, M.H.K. (1972). Is ceruloplasmin a physiological ferroxidase? Clinical Biochemistry 5, 115–120.CrossRefGoogle ScholarPubMed
Suttle, N.F., Jones, D.G., Woolliams, C. & Woolliams, J.A. (1987). Heinz body anaemia in lambs with deficiencies of copper or selenium. British Journal of Nutrition 58, 539–548.Google Scholar
Wallenstein, S., Zucker, C.L. & Fleiss, J.L. (1980). Some statistical methods useful in circulation research. Circulation Research 47, 1–9.Google Scholar
Williams, D.M., Loukopoulos, D., Lee, G.R. & Cartwright, G.E. (1976). Role of copper in mitochondrial iron metabolism. Blood 48, 77–85.Google Scholar
Williams, R.S., Marshall, P.C., Lott, I.T. & Caviness, V.S. (1978). The cellular pathology of Menkes steely hair syndrome. Neurology 28, 575–583.Google Scholar