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Effects of dietary fatty acid composition on basal and hormone-stimulated hepatic lipogenesis and on circulating lipids in the rat

Published online by Cambridge University Press:  09 March 2007

Antonios Zampelas ,
Linda M. Morgan ,
Nigel Furlonger  and
Christine M. Williams
Antonios Zampelas
Affiliation:
The Nutritional Metabolism Research Group, School of Biological Sciences, University of Surrey, Guildford GU2 5XH
Linda M. Morgan
Affiliation:
The Nutritional Metabolism Research Group, School of Biological Sciences, University of Surrey, Guildford GU2 5XH
Nigel Furlonger
Affiliation:
The Nutritional Metabolism Research Group, School of Biological Sciences, University of Surrey, Guildford GU2 5XH
Christine M. Williams
Affiliation:
The Nutritional Metabolism Research Group, School of Biological Sciences, University of Surrey, Guildford GU2 5XH
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Abstract

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Thirty male rats were randomly assigned to one of three dietary groups in which the source of dietary fat was either a mixed oil, maize oil or fish oil. Effects of dietary fatty acid composition on in vitro rates of [U-14C]glucose incorporation into hepatic total lipids and into hepatic triacylglycerol were measured under basal, insulin (4 nM)-, gastric inhibitory polypeptide (GIP; 6 nM)- and insulin + GIP (4 nM + 6nM)-stimulated conditions. Effects of the three diets on postprandial plasma triacylglycerol, cholesterol, insulin and GIP concentrations were also measured. The fish-oil diet decreased rates of basal glucose incorporation into hepatic total lipids (P < 0·05) and hepatic triacylglycerol (P < 0·01) compared with the mixed-oil diet. The presence of insulin and GIP in the incubation medium stimulated glucose incorporation into hepatic total lipids in the maize-oil (P < 0·01) and fish-oil groups (P < 0·05), as well as into hepatic triacylglycerol in the maize-oil group (P < 0·005). In addition, the fish-oil diet decreased postprandial plasma triacylglycerol levels compared with both other dietary groups (P < 0·05 both cases), and the mixed-oil diet markedly increased postprandial plasma insulin levels compared with the other dietary groups (P < 0·001).

Keywords

Saturated fatty acidsPolyunsaturated fatty acidsLipidsHormonesRats
Type
Fatty acid intake and hepatic lipogenesis
Information
British Journal of Nutrition , Volume 74 , Issue 3 , September 1995 , pp. 381 - 392
Copyright
Copyright © The Nutrition Society 1995

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